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2022 RESEARCH

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UMass Chan research explores differences in AAV vector manufacture, shows clear winner for method

UMass Chan research explores differences in AAV vector manufacture, shows clear winner for method

A paper from the Horae Gene Therapy Center at UMass Chan Medical School may settle a longstanding debate about how to best manufacture adeno-associated virus vectors for gene therapy.

Just how accurate are rapid antigen tests? Two testing experts explain the latest data

Just how accurate are rapid antigen tests? Two testing experts explain the latest data

In an article written for The Conversation, Nate Hafer, PhD, and Apurv Soni, MD, PhD'21, explain the data regarding accuracy of rapid COVID tests, based on their extensive reseach as part of the RADx team.

Study co-authored by UMass Chan researchers finds broad differences in SARS-CoV-2 infectiousness

Study co-authored by UMass Chan researchers finds broad differences in SARS-CoV-2 infectiousness

Wide variation in the amount or infectiousness of SARS-CoV-2 among people in early stages of COVID-19 may be an explanation for the phenomenon of “super spreaders,” according to new research. Research co-author Laura Gibson, MD, talks about the findings. 

MassBiologics research into preventive shot for Lyme disease continues to move forward

MassBiologics research into preventive shot for Lyme disease continues to move forward

The human clinical trial into a preventive shot for Lyme disease, developed by MassBiologics at UMass Chan Medical School, continues to show promise, with Phase I expected to conclude this year and Phase II-III plans in development.

Job Dekker elected to National Academy of Sciences

Job Dekker elected to National Academy of Sciences

UMass Chan Medical School scientist Job Dekker, PhD, was elected to the National Academy of Sciences on May 3 for his contributions to the field of genomics.

PhD student Megan Honeywell receives prestigious Ruth L. Kirschstein Predoctoral award

PhD student Megan Honeywell receives prestigious Ruth L. Kirschstein Predoctoral award

In her preliminary studies, PhD student Megan Honeywell has found that cells can trigger a cell death even when they do not have the p53 protein, the so-called “guardian of the genome.”

Communicating science: Andrei Korostelev using structural biology to tackle antibiotic resistance

Communicating science: Andrei Korostelev using structural biology to tackle antibiotic resistance

A recent survey of health care professionals showed nearly 60 percent of participants encountered patients whose infections didn’t respond to any antibiotic. Andrei Korostelev, PhD, says by studying the biology of bacterial cells, effective new antibiotics can be developed.

UMass Chan study shows canine behavior only slightly influenced by breed

UMass Chan study shows canine behavior only slightly influenced by breed

A UMass Chan Medical School genetic study of more than 2,000 purebred and mixed-breed dogs, published in Science, shows that behavioral traits in dogs are not specific for breed. That means a golden retriever, for example, is only slightly more likely to be friendly than another breed.

Massachusetts jails found ‘innovative solutions’ to implement medical treatment for opioid use disorder

Massachusetts jails found ‘innovative solutions’ to implement medical treatment for opioid use disorder

In two new papers, a team of Massachusetts researchers, including faculty from UMass Chan Medical School, examined the implementation of a groundbreaking opioid use disorder medication treatment program in seven jails across the state, part of a $155 million national effort to address the opioid crisis in criminal justice settings.

UMass Chan research supports development of new suppressor-tRNA-based gene therapies

UMass Chan research supports development of new suppressor-tRNA-based gene therapies

Guangping Gao, PhD, and Dan Wang, PhD, show the first evidence that a suppressor transfer RNA therapy, delivered by a recombinant adeno-associated virus, can restore protein production up to six months after treatment in a mouse model of the rare genetic disease mucopolysaccharidosis type I.

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