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National Research Collaborations

The Meyers Primary Care Institute leverages the research capabilities of a collective network of organizations committed to advancing clinical practice through quality research.

Below is a list of research networks we are currently affiliated with.

The AGING Initiative was funded in 2014 by the National Institute on Aging (1R24 AG045050), and is now funded by the National Institute on Aging R33 (AG057806) as of 2018.The HCSRN-OAICs AGING Initiative is an exciting opportunity to build upon the collective and complementary knowledge, resources, and capabilities of the HCSRN and the OAICs to develop an interdisciplinary research agenda focused on older adults with MCCs under a new HCSRN-OAICs AGING (“Advancing Geriatrics Infrastructure & Network Growth”) Initiative.The goal of the AGING Initiative is to bridge the Health Care Systems Research Network (HCSRN) with the Claude D. Pepper Older Americans Independence Centers (OAIC) to create a national resource to nurture and advance an interdisciplinary research agenda focused on older adults with multiple chronic conditions (MCCs). These efforts will lay the foundation to address the knowledge gaps that exist regarding the health and healthcare of these understudied patients.

Principal Investigator: Jerry H. Gurwitz, MD  

The All of Us Research Program is funded and managed by the National Institute of Health (NIH) with the goal of advancing precision medicine.  Precision medicine takes into account individual differences in factors like where you live (environment), what you do (lifestyle), and your family health history (genetics) to tailor healthcare around the individual - a contrast to the current healthcare system that applies a "one size fits all" approach when treating patients.  The All of Us Research Program aims to collect data to allow researchers to determine whether these differences may influence the type of treatment that would work best for an individual.  The Program's goal is to recruit at least one million participants from diverse backgrounds across the United States.  By harnessing information from over one million people over a period of ten years, researchers will be able to investigate more effective way to treat disease and change the face of medicine.  Meyers Primary Care Institute is partnering with Reliant Medical Group to enroll adults in central Massachusetts. 

MPCI Lead / Contact: Mara M. Epstein, ScD

The Cancer Research Network (CRN) supports and facilitates cancer research in non-profit integrated healthcare delivery settings that improves knowledge about cancer etiology, prevention, early detection, treatment and prognosis, and that decreases the burden of cancer across the cancer care spectrum. This work is conducted across the healthcare settings of 9 members of the Health Care Systems Research Network (HCSRN), providing access to approximately 9 million enrollees.

Investigator: Lawrence Kushi, ScD, Kaiser Permanente, Division of Research
MPCI Lead / Contact: Mara M. Epstein, ScD


The Cardiovascular Research Network (CVRN) is a national collaborative that leverages the expertise, populations, and data sources from a consortium of 14 geographically diverse health plans across the United States. The goals of the CVRN are to provide robust cardiovascular disease data and promote research on clinical practice, quality of care, and determinants of disease. The CVRN is funded by the National Heart, Lung and Blood Institute.
Principal Investigator: Alan Go, MD, Kaiser Permanente, Division of Research

MPCI Lead / Contact: Jerry H. Gurwitz, MD  


The Health Care Systems Research Network (HCSRN) brings together the research departments of some of the nation's best and most innovative health care systems. Collectively, the HCSRN represents more than 1,900 scientists and research staff with methodological and content expertise from an array of disciplines such as epidemiology, economics, disparities, outcomes and quality assessment, trials, and genomics. The mission of the HCSRN is to improve individual and population health through research that connects the resources and capabilities of learning health care systems.The Health Care Systems Research Network, formerly known as the HMO Research Network, is the nation’s preeminent source of population-based research that measurably improves health and health care.

MPCI Governing Board Member: Kathleen Mazor, EdD

Health Systems Node
The Health Systems Node of the Clinical Trials Network (CTNHSN), through support from the National Institute on Drug Abuse aims to identify research questions that matter to patients, healthcare providers, and healthcare systems, efficiently answer those questions involving real-world patients and providers, and disseminate and implement research results.  

MPCI Lead / Contact: Robin Clark, PhD


Medical Exposure in Pregnancy Risk Evaluation Program (MEPREP)

MEPREP is a collaboration between the U.S. Food and Drug Administration, 11 Health Care Systems Research Network sites, and Vanderbilt University. The program is the largest of its kind that is developing the infrastructure to enhance the ability to study the effects of medication exposure during pregnancy on the fetus by creating and maintaining linked data on mothers and infants. The 11 participating MEPREP sites have healthcare information for approximately 1 million births over a seven year period.

Principal Investigator: Richard Platt, MD, MSc, Harvard Pilgrim Healthcare Institute
MPCI Lead / Contact: Susan Andrade, ScD

Sentinel Logo
The Sentinel initiatives are funded by the U.S. Food and Drug Administration and include at least 13 care organizations covering more than 12 million lives. The Sentinel project goal is to create a linked and sustainable system that will draw on existing automated healthcare data from multiple sources to actively monitor the safety of medical products. 

Principal Investigator: Richard Platt, MD, MSc, Harvard Pilgrim Healthcare Institute 
MPCI Lead / Contact: Susan Andrade, ScD


The STRIDE (Strategies to Reduce Injuries and Develop Confidence in Elders) Study is supported by a grant award from the National Institute on Aging (NIA) in partnership with the Patient-Centered Outcomes Research Institute (PCORI), as part of the Falls Injuries Prevention Partnership of the organizations.The study’s approach differs from others in that it integrates proven falls reduction strategies into a cohesive intervention that can be adopted by many health care systems.The trial is led by Shalender Bhasin, M.D., Brigham and Women’s Hospital, Harvard Medical School, Boston; Thomas Gill, M.D., Yale School of Medicine, New Haven, Connecticut; and David Reuben, M.D., David Geffen School of Medicine at the University of California, Los Angeles. The team includes more than 100 researchers, stakeholders, patients and their representatives at 10 clinical health system sites across the country.

MPCI Lead / Contact: Jerry H. Gurwitz, MD  

We believe in strength in numbers, and our work is underpinned by a spirit of collaboration and consultation. This benefits the health and wellbeing of our community, and beyond.