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Selected Publications

Multi-CUT&Tag to simultaneously profile multiple chromatin factors.
Sneha Gopalan, Thomas G Fazzio
STAR Protoc. 2022 Jan 20;3(1):101100. doi: 10.1016/j.xpro.2021.101100. eCollection 2022 Mar 18.

TAF4b transcription networks regulating early oocyte differentiation.
Megan A Gura, Soňa Relovská, Kimberly M Abt, Kimberly A Seymour, Tong Wu, Haskan Kaya, James M A Turner, Thomas G Fazzio, Richard N Freiman
Development 2022 Feb 1;149(3):dev200074. doi: 10.1242/dev.200074. Epub 2022 Feb 9.

Simultaneous profiling of multiple chromatin proteins in the same cells figure

Simultaneous profiling of multiple chromatin proteins in the same cells.
Sneha Gopalan, Yuqing Wang, Nicholas W Harper, Manuel Garber, Thomas G Fazzio
Mol Cell 2021 Nov 18;81(22):4736-4746.e5. doi: 10.1016/j.molcel.2021.09.019. Epub 2021 Oct 11.

 Characterization of R-Loop-Interacting proteins in embryonic stem cells reveals roles in rRNA processing and gene expression figure

Characterization of R-Loop-Interacting Proteins in Embryonic Stem Cells Reveals Roles in rRNA Processing and Gene Expression.
Tong Wu, Jennifer Nance, Feixia Chu, Thomas G Fazzio
Mol Cell Proteomics 2021;20:100142. doi: 10.1016/j.mcpro.2021.100142. Epub 2021 Aug 31.


Profiling of Pluripotency Factors in Single Cells and Early Embryos.
Hainer SJ, Bošković A, McCannell KN, Rando OJ, Fazzio TG.
Cell. 2019 April 2. pii: S0092-8674(19)30276-4. doi: 10.1016/j.cell.2019.03.014. [Epub ahead of print]

High-Resolution Chromatin Profiling Using CUT&RUN.
Hainer SJ, Fazzio TG.
Curr Protoc Mol Biol. 2019 Apr;126(1):e85.

TIP55, a splice isoform of the KAT5 acetyltransferase, is essential for developmental gene regulation and organogenesis.
Acharya D, Nera B, Milstone ZJ, Bourke L, Yoon Y, Rivera-Pérez JA, Trivedi CM, Fazzio TG.
Sci Rep. 2018 Oct 8;8(1):14908. doi: 10.1038/s41598-018-33213-4.


An Embryonic Stem Cell-Specific NuRD Complex Functions through Interaction with WDR5.
Ee LS, McCannell KN, Tang Y, Fernandes N, Hardy WR, Green MR, Chu F, Fazzio TG.
Stem Cell Reports. 2017 Jun 6;8(6):1488-1496.       

KAT-Independent Gene Regulation by Tip60 Promotes ESC Self-Renewal but Not Pluripotency.
Acharya D, Hainer SJ, Yoon Y, Wang F, Bach I, Rivera-Pérez JA, Fazzio TG.
Cell Rep. 2017 Apr 25;19(4):671-679.

Hainer SJ, McCannell KN, Yu J, Ee LS, Zhu LJ, Rando OJ, Fazzio TG.
Elife. 2016 Nov 16;5. pii: e21964.

Regulation of chromatin structure and cell fate by R-loops.
Fazzio TG.
Transcription. 2016 Aug 7;7(4):121-6.

R loops regulate promoter-proximal chromatin architecture and cellular differentiation.
Chen PB, Chen HV, Acharya D, Rando OJ, Fazzio TG.
Nat Struct Mol Biol. 2015 Dec;22(12):999-1007.     


Suppression of pervasive noncoding transcription in embryonic stem cells by esBAF.
Hainer SJ, Gu W, Carone BR, Landry BD, Rando OJ, Mello CC, Fazzio TG.
Genes Dev. 2015 Feb 15;29(4):362-78. 

Unbiased chromatin accessibility profiling by RED-seq uncovers unique features of nucleosome variants in vivo.
Chen PB, Zhu LJ, Hainer SJ, McCannell KN, Fazzio TG.
BMC Genomics. 2014 Dec 15;15:1104.

High-resolution mapping of chromatin packaging in mouse embryonic stem cells and sperm.
Carone BR, Hung JH, Hainer SJ, Chou MT, Carone DM, Weng Z, Fazzio TG, Rando OJ.
Dev Cell. 2014 Jul 14;30(1):11-22.

Hdac6 regulates Tip60-p400 function in stem cells.
Chen PB, Hung JH, Hickman TL, Coles AH, Carey JF, Weng Z, Chu F, Fazzio TG.
Elife. 2013 Dec 3;2:e01557.

NURDs are required for diversity.
Fazzio TG, Rando OJ.
EMBO J. 2012 May 11;31(14):3036-7.

Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells.
Yildirim O, Li R, Hung JH, Chen PB, Dong X, Ee LS, Weng Z, Rando OJ, Fazzio TG.
Cell. 2011 Dec 23;147(7):1498-510.