All Publications

90. Das S, Hehnly H, Doxsey S. A new role for Rab GTPases during early mitotic stages. Small GTPases: 2014.

89. Chen CT, Hehnly H, Yu Q, Farkas D, Zheng G, Redick SD, Hung HF, Samtani R, Jurczyk A, Akbarian S, Wise C, Jackson A, Bober M, Guo Y, Lo C, Doxsey S. A unique set of centrosome proteins requires pericentrin for spindle-pole localization and spindle orientation. Curr Biol: 2014. Get Commentary in Curr Biol 24(19):R962-4

88. Hehnly H, Doxsey S. Rab11 endosomes contribute to mitotic spindle orientation. Developmental Cell 28, 497-507, 2014. Get Commentary in Dev Cell 28, 480-482. Ahna Skop.

87. Hung, H-F, Hehnly H, Doxsey S. Multiplying madly: Deacetylases take charge of centrosome duplication and amplification. Cell Cycle 11: 3779-91, 2012.

86. Chen, C-T, Doxsey S. An MBoC Favorite: Role of GTP hydrolysis in microtubule dynamics: information from a slowly hydrolyzable analogue, GMPCPP. Molecular Biology of the Cell 2012 Oct23(19):3775.

85. Foraker A, CamusS, Evans T, Majeed S, Chen C, Taner S, Corrêa I, Doxsey S, and Brodsky F.  Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG, J Cell Biol. 2012 Aug 20; 198(4):591-605. (Highlighted in J Cell Biology 198, 473, 2012; Faculty 1000).

84. Hehnly, Chen, C-T, Powers CM, Liu HL, and Doxsey, Centriolin anchoring of endosomes at centrosome appendages is required for endosome function. Current Biol, 2012 Oct 23;22(20):1944-50. (Highlighted in Nature Reviews Molecular Cell Biology 13 750, 2012; Faculty 1000-Toomre).

83. Chen C-T, Hehnly H, Doxsey S, Orchestrating vesicle transport, ESCRTs and kinase surveillance during abscission. Nature Reviews Molecular Cell Biology, 2012 Jul 11;13(8):483-8.

82. Chen C-T, Ettinger A, Huttner, W, and Doxsey S. Resurrecting Remnants: The lives of Post-Mitotic Midbodies. Trends Cell Biol. 2012 Dec 11. pii: S0962-8924(12)00204-8. doi: 10.1016/j.tcb.2012.10.012. [Epub ahead of print]

81. Hehnly H, Doxsey S. Polarity sets the stage for cytokinesis. Mol Biol Cell. 2012 Jan;23(1):7-11.

80. Kuo TC, Doxsey S. Fates and roles of post-mitotic midbodies beyond cytokinesis. Cell Cycle. 2012 Jan 1;11(1):7-8.

79. *Kuo TC, *Chen CT, Baron D, Onder TT, Loewer S, Almeida S, Weismann CM, Xu P, Houghton JM, Gao FB, Daley GQ, Doxsey S. Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity. Nat Cell Biol. 2011; 13(10):1214-23. *Co-first authors. (See highlights in Current Biology 21, R958-59; Nature Reviews Molecular Cell Biology 12, 690-1, 2010; “The Scientist” September 11, 2001; The Keck Foundation Annual Report 2011, p. 8-10); (GET commentary Laurence Pelletier, Yukiko Yamashita)

78. Delaval B, Covassin L, Lawson ND, Doxsey S. Centrin depletion causes cyst formation and other ciliopathy-related phenotypes in zebrafish. Cell Cycle. 10: 3964-72, 2011. (Highlighted in Cell Cycle 11, p. 16, 2012).

77. Delaval B, Bright A, Lawson ND, Doxsey S. The cilia protein IFT88 is required for spindle orientation in mitosis. Nat Cell Biol. Apr; 13(4): 461-8. 2011 (Highlighted on April 4, 2011 in Science Daily; RedOrbit; Medical News Today; Eureka Alert).

76. Patzke S, Redick S, Warsame A, Murga-Zamalloa CA, Khanna H, Doxsey S, Stokke T. CSPP is a ciliary protein interacting with Nephrocystin 8 and required for cilia formation. Mol Biol Cell. 2010 Aug 1; 21(15):2555-67.

75. Delaval B and Doxsey S. Pericentrin in development and disease. J Cell Biol, 188, 181-190, 2009.

74. Chen, C-T and Doxsey S.  A last minute rescue of trapped chromatin. Cell, 136, 397-399, 2009.

73. Mylavarapu VSS, Wadzinski TL1*, Redick SD1, Manna T1 and Doxsey SJ1.  Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint. EMBO J Apr 8;28(7), 902-14, 2009.

72. Fitzgerald TJ, Wang T, Goel HL, Huang J, Stein G, Lian J, Davis RJ,  Doxsey S, Balaji KC, Aronowitz J, Languino LR.  Prostate carcinoma and radiation therapy: therapeutic treatment resistance and strategies for targeted therapeutic intervention. Expert Rev Anticancer Ther. 2008 Jun;8(6):967-74.

71. Man C, Rosa J, Yip YL, Cheung AL, Kwong YL, Doxsey  SJ, Tsao SW. Id1 overexpression induces tetraploidization and multiple abnormal mitotic phenotypes by modulating aurora a. Mol Biol Cell. 2008 Jun;19(6):2389-401.

70. Kang BH, Plescia J, Dohi T, Rosa J, Doxsey SJ, Altieri DC.  Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network.  Cell. 2007 Oct 19;131(2):257-70.

69. Blazkova H, von Schubert C, Mikule K, Schwab R, Angliker N, Schmuckli-Maurer J, Fernandez PC, Doxsey S, Dobbelaere DA.  The IKK inhibitor BMS -345541 affects multiple mitotic cell cycle transitions.  Cell Cycle.  2007 Oct 15;6(20):2531-40.

68. Delaval B, Doxsey S.  Genetics. Dwarfism, where pericentrin gains stature. Science. 2008 Feb 8;319(5864):732-3.

67. Sillibourne JE, Delaval B, Sinhah M, Doxsey SJ. Chromatin remodeling proteins interact with pericentrin to regulate centrosome integrity. Mol Biol Cell. 2007 Sep;18(9):3667-80.

66. Mikule K, Delaval B, Kaldis P, Jurcyzk A, Hergert P, Doxsey S. Loss of centrosome integrity induces p38/p53/p21-dependent G1/S arrest. Nature Cell Biol 9, 160-170, 2007.

65. Pockwinse SM, Rajgopal A, Young DW, Mujeeb KA, Nickerson J, Javed A, Redick S, Lian JB, van Wijnen AJ, Stein JL, Stein GS,  Doxsey SJ. Microtubule-dependent nuclear-cytoplasmic shuttling of Runx2. J Cell Physiol 206, 354-62, 2006..

64. Parish JL, Rosa J, Wang X, Lahti JM,  Doxsey SJ, Androphy EJ. The DNA helicase ChlR1 is required for sister chromatid cohesion in mammalian cells. J. Cell Sci 119, 4857-65, 2006.

63. Man C, Rosa J, Lee LT, Lee VH, Chow BK, Lo KW,  Doxsey S, Wu ZG, Kwong YL, Jin DY, Cheung AL, Tsao SW. Latent membrane protein 1 suppresses RASSF1A expression, disrupts microtubule structures and induces chromosomal aberrations in human epithelial cells. Oncogene 26, 3069-80, 2006.

62. Rosa J, Canovas P, Islam A, Altieri D, Doxsey S. Survivin modulates microtubule dynamics and nucleation throughout the cell cycle. Mol Biol Cell 17, 1483-1493, 2006 (with cover photo).

61. Golubkov VS, Chekanov AV, Doxsey SJ, Strongin AY. Centrosomal pericentrin is a direct cleavage target of membrane type-1 matrix metalloproteinase in humans but not in mice: potential implications for tumorigenesis. J Biol Chem, 280, 42237-41, 2005.

60. Doxsey SJ. Molecular links between centrosome and midbody. Mol Cell, 20, 170-2, 2005.

59. Gromley A, Yeaman C, Rosa J, Redick S, Chen C, Mirabelle S, Guha M, Sillibourne J, and Doxsey S. Centriolin Anchoring of Exocyst and SNARE Complexes at the Midbody Is Required for Secretory-Vesicle-Mediated Abscission. Cell, 123, 75-87, 2005 (see reviews/highlights in Dev Cell 9, 578-580, 2005; Curr Biol 15, R998-1000, 2005; J Cell Biol 171, 192, 2005).

58. Doxsey S, McCollum D, Theurkauf W. Centrosomes in cellular regulation. Ann Rev Cell Biol 21, 411-434, 2005

57. Doxsey S, Zimmerman W, Mikule K. Centrosome control of the cell cycle. Trends Cell Biol. 15, 303-311, 2005.

56. Golubkov VS, Boyd S, Savinov AY, Chekanov AV, Osterman AL, Remacle A, Rozanov DV, Doxsey SJ, and Strongin AY.  Membrane type-1 matrix metalloproteinase (MT1-MMP) exhibits an important intracellular cleavage function and causes chromosome instability. J Biol Chem, 280, 25079-86, 2005.

55. Jurczyk A., Gromley A., Redick S. San Augustin J., Witman G., Pazour G., Peters J.M. and Doxsey S. Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly. J. Cell Biol. 166, 637-643, 2004 (see  ‘Dispatch’ in Curr. Biol, 2004; Highlights in J Cell Biol, 2004).

54. Zimmerman, W. Sillibourne, J. Rosa, J. and Doxsey. S. J. Mitosis-specific anchoring of gamma tubulin complexes by pericentrin controls spindle organization and mitotic entry. Mol. Biol. Cell, 15, 3642-3657, 2004.

53. Gavanescu, I., Pihan, G., Halilovic, E., Szomolanyi-Tsuda, E, Welsh, R., and Doxsey, S..Mycoplasma infection induces a scleroderma-like centrosome autoantibody response in mice. Clin Exp Immun 137, 288-297, 2004.

52. Gandhi, R, Bonaccorsi S, Wentworth D, Doxsey S, Gatti M, Pereira A. The Drosophila kinesin-like protein KLP67A is essential for mitotic and male meiotic spindle assembly. Mol. Biol. Cell 15, 121-131, 2004.

51. *Chen, D., *Purohit, A., Halilovic, E. and Doxsey, S. Protein kinase C anchoring at the centrosome controls cytokinesis. *Authors contributed equally. J. Biol. Chem., 279, 4829, 2004 (with COVERPHOTO).

50. Pihan, G. and Doxsey, S. Mutations and aneuploidy: Co-conspirators in cancer? Cancer Cell 4, 89-94, 2003.

49. Gromley, A., Jurczyk, A., Sillibourne, J., Halilovic, E., Powers, C., Craig., R. Blomberg, M., Mogensen, M. and Doxsey, S. Identification of a novel vertebrate pathway involved in cytokinesis and cell cycle progression.  J. Cell Biol, 161, 535-545, 2003 (see Highlights in Developmental Cell 9, 578-580, 2005; Curr. Biol. 13, R646-8, 2005; J. Cell Biology 171, 192, 2005).

48. Pihan, G. Zhou, Y., Wallace, J., Zhou, Y. and Doxsey, S. Centrosome abnormalities and genetic instability occur together in precancerous lesions. Cancer Research, 63, 1398-1404, 2003.

47. Doxsey, S. Duplicating dangerously: linking centrosome duplication and aneuploidy. Molecular Cell 10, 1-2, 2002.

46. Doxsey, S.J. Re-evaluating centrosome function. Nature Reviews in Molecular Biology 2, 688-699 (2001).

45. Pihan, G., Purohit, A., Wallace, J., Liotta, L. and Doxsey, S. Centrosome defects can account for the cellular and genetic changes that accompany prostate cancer progression. Cancer Res. 61, 2212-2219 (2001) (see editorial in Science 292, 426-429, 2001).

44. Purohit, A., Pihan, G. and Doxsey. Methods for studying pericentrin in centrosome assembly and function. Meth. Cell Biol. 67, 54-68 (2001).

43. Doxsey, S.J. Centrosomes as command centers for cellular control. Nat. Cell Biol. 3, E1-E3, 2001.

42. Zimmerman, W. and Doxsey, S.J. Construction of centrosomes and spindle poles by molecular motor driven transport of protein particles. Traffic 1 (12), 927-934, 2000.

41. Tynan, S., Purohit, A., Doxsey, S. J. and Vallee, R. A distinct subclass of cytoplasmic dynein containing light intermediate chain 1 is specific for pericentrin binding. J. Biol. Chem. 275, 32763-32768, 2000.

40. Diviani, D., Langeberg, L., Doxsey, S.J.  and Scott, J. Pericentrin anchors protein kinase A at the centrosome through a newly identified RII-binding domain. Current Biology, 10, 417-420, 2000.

39. Young, A., Dictenberg, J., Purohit, A., Tuft, R. and Doxsey, S.J. Cytoplasmic dynein-mediated assembly of pericentrin and gamma tubulin onto centrosomes. Mol. Biol. Cell. 11, 2047-2056, 2000.

38. Purohit, A. Tynan SH, Vallee, R, and Doxsey, S. Direct interaction of pericentrin and dynein light intermediate chain contributes to mitotic spindle organization. J. Cell Biol. 147, 481-491, 1999.

37. Doxsey, S.J. and Pihan, G. The mitotic machinery as a contributor to tumorigenesis. Sem. in Cancer Biol. 9, 289-302, 1999.

36. Gavanescu, I., Vazquez, L., McCauley, J., Senecal, J-L. and S. Doxsey. Centrosome proteins: a major class of autoantigens. J. Clin. Immunol., 19, 166-171, 1999.

35. Zimmerman, W., Sparks, C. and Doxsey, S. Amorphous no longer: the centrosome comes into focus. Curr. Opin. Cell Biol. 11, 122-128, 1999.

34. Doxsey, S.J. Pericentrin, In: Guidebook to Cytoskeletal and Motor Proteins, Cambridge Univ. Press, Lon. eds. R. Vale and T. Kreis., 1998.

33. Young, A., Tuft, R., Carrington, W. and Doxsey, S. Centrosome dynamics in living cells. Meth. Cell Biol. 58, 223-238, 1999.

32. Blomberg, M. and Doxsey, S.J.  Rapid isolation of centrosomes. Meth. Enzymol.  298, 228-238, 1998.

31. Doxsey, S.J. The centrosome--a tiny organelle with big potential. Nature Genetics 20, 104-106,1998.

30. Pihan, G., Purohit, A., Knecht, H. Woda, B. Quesenberry, P. and Doxsey, S.J. Centrosome defects and genetic instability in malignant tumors. Cancer Research , 58, 3974-3985,1998.

29. Dictenberg, J., Zimmerman , W., Sparks, C., Young, A., Carrington, Zheng , Y., Vidair, C., W. Fay, F. and Doxsey, S. Pericentrin and  tubulin form a protein complex and are organized into a novel  lattice at the centrosome. J. Cell Biol. 141, 163-174, 1998 (with COVERPHOTO).

28. Bangs, P., Burke, B. , Powers, C. Craig., R. Purhoit, A. and Doxsey, S.J.Functional analysis of Tpr: identification of nuclear pore complex association and nuclear localization domains and a role in mRNA export. J. Cell Biol. 143:  1801-1812, 1998.

27. Tucker, J., Mogensen, M.M.,. Henerson, C.G., Doxsey, S., Wright, M. and Stearns, T.  Nucleation and capture of large cell surface-associated microtubule arrays that are not located near centrosomes in certain cochlear epithelial cells. J. Anat. 192, 119-130, 1998.

26. Pockwinse, S.M., Krockmalnic, G., Doxsey, S.J., Nickerson, J. Lian, F.B. van Wijnen, A., Stein, J.L. Stein, G. and Penman, S. Cell cycle independent interaction of CDC2 with the centrosome, which is associated with the nuclear matrix-intermediate filament scaffold. Proc. Natl. Acad. Sci. 94, 3022-3027, 1997.

25. Mogensen, M, J. Tucker, J. Mackie, C. Henderson, S. Doxsey and T. Stearns. Centrosomal deployment of gamma tubulin and pericentrin: evidience for a microtubule nucleating domain and a minus end docking domain in mouse epithelial cells. Cell Motil. Cytoskel. 36, 276-290, 1997.

24. Pereira, AJ, Dalby, B, Stewart, RJ, Doxsey, S. and Goldstein, LSB. The kinesin-like protein, KLP67A is a plus-end directed microtubule motor expressed during Drosophila mitosis. J. Cell Biol. 136,  1081-1090, 1997.

23. Brown, R.,  L.Q. Hong-Brown,  Doxsey, S.J. and Welch, W. Centrosomal repair following heat shock treatment invloves the molecular chaperone hsp 73. J. Biol. Chem. 271, 833-40, 1996.

22. Brown, R., Doxsey, S.J., L.Q. Hong-Brown, Martin, RL. and Welch, W. Molecular chaperones and the centrosome: A role for TCP-1 in  microtubule nucleation. J. Biol. Chem. 271, 824-32, 1996.

21. Vidair, C.V., Huang, R.N. and Doxsey, S.J. Heat shock causes protein aggregation and reduced protein solubility a t the centrosome and other cytoplasmic locations. Int. J. Hyperthermia 12, 681-695, 1996.

20. Vidair, C.A., Doxsey, S.J., and Dewey, W.C.  Thermotolerant cells possess an enhanced capacity to repair heat-induced alterations to centrosome function. J. Cell. Physiol.,163, 194 (1995).

19. Shisheva, A,  Doxsey, S.J, Buxton, J., and Czech, M. Pericentriolar targeting of GDP-dissociation inhibitor isoform 2.  Eur. J. Cell Biol, 68, 143-158, 1995.

18. Sparks, C., Fey, E., Vidair, C. and Doxsey, S.J  NuMA phosphorylatation occurs during nuclear breakdown not spindle formation J. Cell Sci.,108, 3389-3396 (1995) (with COVERPHOTO).

17. Brown, R., Doxsey, S.F., White, E., and Welch, W. Both viral (adenovirus E1a) and cellular (hsp70, p53) components interact with centrosomes. J. Cellular Physiol. J. Cell. Physiol. 160, 47-60 (1994).

16. Doxsey, S.J., Stein, P., Evans, L., Calarco, P., and Kirschner, M.W. Pericentrin, a highly conserved centrosome protein involved in microtubule organization. Cell 76, 639-50 (1994) (with COVERPHOTO).

15. Vidair, C.A., Doxsey, S.J. and Dewey, W.C. Heat shock alters centrosome organization leading to mitotic dysfunction and cell death. J. Cell. Physiol. 154, 443-455 (1993).

14. Doxsey, S.J. and White, J. Erythrocyte-mediated transfer of macromolecules into somatic cells using the hemagglutinin protein of Influenza virus. In:  Protocols in Cell and Tissue Culture. J.B. Griffiths, A. Doyle and D.G. Newell, eds. Wiley and Sons, England.  (1992)

13. Gard, D.C., Mafezi, S., Zhang, T. and Doxsey, S.J. Centrosome duplication continues in cycloheximide-treated Xenopus blastulae in the absence of a detectable cell cycle.  J. Cell Biol. 110: 2033-2042. (1990).

12. Ellens, H.,  Doxsey, S., Glenn, J. and White, J. Delivery of macromolecules into cells expressing a viral membrane fusion protein. In:  Methods in Cell Biology. Volume 31, Vesicular Traffic, Ch. 9,  p. 155-76.  A Tartakoff, ed. (1989).

11. Doxsey, S.J.  The use of viral membrane fusion proteins in drug delivery to trypanosomes.  In: Chemotherapy for Trypanosomiasis, A.S. Peregrine, ed., pp. 123-131. (1989).

10. Helenius, A., Doxsey, S.J. and Mellman, I. Viruses as tools in drug delivery. In: Biological  approaches to the controlled delivery of drugs.  Annal. N. Y. Acad. Sci. 507: 1-6 (1987).

9. Doxsey, S.J., Helenius, A., Blank, G. and Brodsky, F. Inhibition of endocytosis by anti-clathrin antibodies. Cell 50: 458-468 (1987).

8. Doxsey, S.J., Sambrook, J., Helenius, A. and White, J.  An efficient method for introducing macromolecules into living cells.  J. Cell Biol. 101: 19-27 (1985).

7. Moulton, J., Buscher, G., Bovell, D. and Doxsey, S.J. Blast transformation of adherent macrophages infected in vitro with sporozoites of Theileria parva.  Am. J. Vet. Res. 45: 678-684 (1984).

6. Fawcett, D.W., Buscher, G. and Doxsey, S.J. Salivary gland of the tick vector (R. appendiculatus) of East Coast Fever.  III. The ultrastructure of sporogony in Theileria parva.  Tiss. and Cell 14:397-414 (1982).

5. Shapiro, S.J. and Doxsey, S.J.  Purification of nuclei from a flagellate protozoan, Trypanosoma brucei.  Anal. Biochem. 127:112-115 (1982).

4. Fawcett, D.W., Stagg, D.A., Doxsey, S.J. and Young, A.S. The entry of sporozoites of Theileria parva into bovine lymphocytes in vitro.  Eur. J. Cell Biol. 27:10-21 (1982).

3. Fawcett, D.W., Buscher, G. and Doxsey, S.J.  Salivary gland of the tick vector (Rhipicephalus appendiculatus) of East Coast Fever.  IV. Cell type selectivity and host response to T. parva.  Tiss. and Cell 14:397-414 (1982).

2. Fawcett, D.W.,  Doxsey, S.J. and Buscher, G.  Salivary gland of the tick vector (R. appendiculatus) of East Coast Fever.  I. Ultrastructure of the type III acinus.  Tiss. and Cell 13:209-230 (1981).

1. Fawcett, D.W., Doxsey, S.J. and Buscher, G. Salivary gland of the tick vector (R. appendiculatus) of East Coast Vever.  II. Cellular basis for fluid secretion in the type III acinus.  Tiss. and Cell 13:231-253 (1981).