Jeanne Hardy, PhD
Research Focus - Structure and Drug Development for Caspases
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Identification of allosteric sites in caspases for development of new inhibitors and activators of cancer
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Small-molecule drug development against caspases
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Development of fluorescence caspase reporters for activity and observing delivery
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Delivery of active caspases for cancer therapy (in collaboration with S. Thayumanavan)
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Co-delivery of caspases and apoptosis modulators
Representative Publication
Dagbay KB, Hardy JA. Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions. Proc Natl Acad Sci USA. 2017;114(30):E7977-E7986.