Buscar Close Search
Buscar Close Search
Page Menu


Radiology Imaging CancerKing, RM, Gounis, MJ, Schmidt, EJ, Leporati, A, Gale,  EM, Bogdanov,  AA Jr. Molecular Magnetic Resonance Imaging of Aneurysmal Inflammation Using a Redox Active Iron Complex. Investigative Radiology, 10.1097, 2023

Silva, HF, Martins, IS, Bogdanov, AA Jr, Tuchin, VV,  Oliveira, LM. Characterization of optical clearing mechanisms in muscle during treatment with glycerol and gadobutrol solutions. Journal of Biophotonics. 16 (1), e202200205, 2023

Kazachkina, NI, Zherdeva, VV, Meerovich, IG , Saydasheva, AN,  Solovyev, ID, Savitsky, AP, Tuchin, VV, Bogdanov, AA Jr. MR and fluorescence imaging of gadobutrol‐induced optical clearing of red fluorescent protein signal in an in vivo cancer model. NMR in Biomedicine 35 (7), e4708, 2022

Bäuerle, T, Gupta,  S, Zheng S, Seyler L, Leporati A, Marosfoi M, Maschauer, S, Prante, O, Caravan, P, Bogdanov A Jr. Multimodal Bone Metastasis-Associated Epidermal Growth Factor Receptor Imaging in an Orthotopic Rat Model. Radiology: Imaging Cancer 3 (4), e200069, 2021 

King, RM, Caroff, J, Langan, ET, Leporati, A, Rodriguez-Rodriguez, A, Raskett, CM, Gupta, S, Puri, AS, Caravan, P, Gounis, MJ, Bogdanov, AA Jr.  In situ decellularization of a large animal saccular aneurysm model: sustained inflammation and active aneurysm wall remodeling. Journal of Neurointerventional Surgery 13 (3), 267-271, 2021

Tuchina, DK, Meerovich, IG, Sindeeva, OA, Zherdeva, VV, Savitsky, AP, Bogdanov, AA Jr, Tuchin, VV. Magnetic resonance contrast agents in optical clearing: Prospects for multimodal tissue imaging. Journal of Biophotonics 13 (11), e201960249, 2020

Theranostics Cover February 2020Metelev, VG, Bogdanov, AA Jr. Synthesis and applications of theranostic oligonucleotides carrying multiple fluorine atoms. Theranostics. 2020; 10(3): 1391-1414. doi: 10.7150/thno.37936

Taghian, T, Metelev, VG, Zhang, S, Bogdanov, AA Jr. Imaging NF-KB activity in a murine model of early stage diabetes. The FASEB Journal. 2020; 34:1198-1210.

Rodriguez-Rodriguez A, Shuvaev S, Rotile N, Jones CM, Probst CK, Dos Santos Ferreira D, Graham-O'Regan K, Boros E, Knipe RS, Griffith JW, Tager AM, Bogdanov A Jr, Caravan P. Peroxidase Sensitive Amplifiable Probe for Molecular Magnetic Resonance Imaging of Pulmonary Inflammation. ACS Sens. 2019 4(9):2412-2419. doi: 10.1021/acssensors.9b01010

Leporati A, Gupta S, Bolotin E, Castillo G, Alfaro J, Gottikh MB, Bogdanov AA Jr. Antiretroviral Hydrophobic Core Graft-Copolymer Nanoparticles: The Effectiveness against Mutant HIV-1 Strains and in Vivo Distribution after Topical Application. Pharm Res. 2019 Mar 27;36(5):73. doi: 10.1007/s11095-019-2604-9.

Alexei A. Bogdanov Jr.; Valeriy G. Metelev; Toloo Taghian; Ilya Solovyev; Anand T. N. Kumar; Surong Zhang; Alexander Savitsky. Near-infrared oligonucleotide duplex sensors for imaging rapidly activated transcription factors in vitro and in situ. Proceedings Volume 10877, Dynamics and Fluctuations in Biomedical Photonics XVI; 1087702 (2019) https://doi.org/10.1117/12.2511124 Event: SPIE BiOS, 2019, San Francisco, California, United States

Munkhbat O, Canakci M, Zheng S, Hu W, Osborne B, Bogdanov AA, Thayumanavan S. 19F MRI of Polymer Nanogels Aided by Improved Segmental Mobility of Embedded Fluorine Moieties. Biomacromolecules. 2019 Feb 11;20(2):790-800. doi: 10.1021/acs.biomac.8b01383.

Bogdanov AA Jr, Solovyev ID, Savitsky AP. Sensors for Proteolytic Activity Visualization and Their Application in Animal Models of Human DiseasesBiochemistry (Mosc). 2019 Jan;84(Suppl 1):S1-S18. doi: 10.1134/S0006297919140013.

Youssef Z. Wadghiri, Dung Minh Hoang, Anita Leporati, Matthew J. Gounis, Aurora Rodríguez-Rodríguez, Mary L. Mazzanti, John P. Weaver, Ajay K. Wakhloo, Peter Caravan, and Alexei A. Bogdanov, Jr. High-resolution Imaging of Myeloperoxidase Activity Sensors in Human Cerebrovascular Disease. Sci Rep. 2018; 8: 7687. Published online 2018 May 16. doi: 10.1038/s41598-018-25804-y, PMCID: PMC5956082, PMID: 29769642.

Nanotheranostics Cover Vol 2 issue 1Zhang S, FitzGerald TJ, Bogdanov, A. Jr. Dual radiosensitization and anti-STAT3 anti-proliferative strategy based on delivery of gold nanoparticle- oligonucleotide nanoconstructs to head and neck cancer cells. Nanotheranostics, 2(1): 1-11. doi:10.7150/ntno.22335, 2018. PDF
Beller E, Reuter L, Kluge A, Preibisch C, Lindauer U, Bogdanov A, Lämmer F, Delbridge C, Matiasek K, Schwaiger BJ, Boeckh-Behrens T, Zimmer C, Gersing AS. Pilot study to assess visualization and therapy of inflammatory mechanisms after vessel reopening in a mouse stroke model. Sci Rep. 2018 Jan 15;8(1):745. doi: 10.1038/s41598-017-17533-5.

Metelev V, Zhang S, Zheng S, Kumar ATN, Bogdanov A Jr., Fluorocarbons Enhance Intracellular Delivery of Short STAT3-sensors and Enable Specific Imaging. Theranostics. 2017 Aug 3;7(13):3354-3368. doi: 10.7150/thno.19704. eCollection 2017.

Anand T. N. Kumar, William L. Rice, Jessica C. López, Suresh Gupta, Craig J. Goergen, and Alexei A. Bogdanov, Jr. Substrate-Based Near-Infrared Imaging Sensors Enable Fluorescence Lifetime Contrast via Built-in Dynamic Fluorescence Quenching Elements. ACS Sensors 2016 1 (4), 427-436 DOI: 10.1021/acssensors.5b00252

Bogdanov AA Jr, Dixon AJ , Gupta S, Zhang L, Zheng S, Shazeeb MS, Zhang S, Klibanov AL. Synthesis and Testing of Modular Dual-Modality Nanoparticles for Magnetic Resonance and Multispectral Photoacoustic ImagingBioconjug Chem. 2016 Feb 17;27(2):383-90. doi: 10.1021/acs.bioconjchem.5b00633. Epub 2015 Dec 10.

Gounis MJ, van der Marel K, Marosfoi M, Mazzanti ML, Clarençon F, Chueh JY, Puri AS, Bogdanov AA Jr. Imaging Inflammation in Cerebrovascular Disease. Stroke. 2015 Oct;46(10):2991-7. doi: 10.1161/STROKEAHA.115.008229. Epub 2015 Sep 8. PMID: 26351362

Chueh JY, Vedantham S, Wakhloo AK, Carniato SL, Puri AS, Bzura C, Coffin S, Bogdanov AA Jr, Gounis MJ. Aneurysm permeability following coil embolization: packing density and coil distribution. Neurointerv Surg. 2015 Sep;7(9):676-81. doi: 10.1136/neurintsurg-2014-011289. Epub 2014 Jul 16. PMID: 25031179

Bogdanov AA Jr, Gupta S, Koshkina N, Corr SJ, Zhang S, Curley SA, Han G. Gold nanoparticles stabilized with MPEG-grafted poly(l-lysine): in vitro and in vivo evaluation of a potential theranostic agentBioconjug Chem. 2015 Jan 21;26(1):39-50. doi: 10.1021/bc5005087. Epub 2014 Dec 11

Gounis MJ, van der Bom IM, Wakhloo AK, Zheng S, Chueh JY, Kühn AL, Bogdanov AA. MR Imaging of Myeloperoxidase Activity in a Model of the Inflamed Aneurysm Wall. AJNR Am J Neuroradiol. 2014 Oct .

Gounis, MJ Vedantham, S, Weaver JP, Puri AS, Brooks CS, Wakhloo AK, Bogdanov AA Jr. Myeloperoxidase in human intracranial aneurysms. Preliminary evidence. Stroke. 2014, 45:1474-1477.doi:10.1161/STROKEAHA.114.004956

Shazeeb MS, Feula G, Bogdanov, A Jr. Liposome-encapsulated superoxide dismutase mimetic: theranostic potential of an MR detectable and neuroprotective agent. Contrast Media Mol. Imaging 2014, 9: 221-228. DOI: 10.1002/cmmi.1559

Metelev V, Zhang S, Tabatadze D, Kumar ATN, Bogdanov, AJr. The three-dimensional context of a double helix determines fluorescence of the internucleoside-tethered pair of fluorophores. Mol Biosyst. 2013,9: 2447-2453.

Shazeeb MS, Gupta S, Bogdanov AA Jr . MR signal amplification for imaging of the mutant EGF receptor in orthotopic human glioma model. Mol Imaging Biol. 2013, 15:675-84. doi: 10.1007/s11307-013-0653-8.

Reichstetter S, Castillo GM, Rubinstein I, Nishimoto-Ashfield A, Lai M, Jones CC, Banjeree A, Lyubimov A, Bloedow DC, Bogdanov A Jr, Bolotin EM. Protected graft copolymer excipient leads to a higher acute maximum tolerated dose and extends residence time of vasoactive intestinal peptide significantly better than sterically stabilized micelles. Pharm Res. 2013; 30: 670-682.

Huang S, Farrar CT, Dai G, Kwon JS, Bogdanov AA Jr, Rosen BR, Kim YR. Dynamic monitoring of blood-brain barrier integrity using water exchange index (WEI) during mannitol and CO2 challenges in mouse brain. NMR Biomed 2013, 26:376­385.

Shazeeb M, Xie Y, Gupta S, Bogdanov A Jr. A novel paramagnetic substrate for detecting myeloperoxidase activity in vivo. Mol Imaging 2012, 11: 1536-0121.

Bogdanov AA, Mazzanti ML. Fluorescent macromolecular sensors of enzymatic activity for in vivo imaging. Prog Mol Biol Transl Sci. 2013;113:349-87. doi: 10.1016/B978-0-12-386932-6.00009-0.

Bogdanov A Jr, Metelev V, Zhang S, Kumar ATN. Sensing of transcription factor binding via cyanine dye pair fluorescence lifetime changes. Mol BioSyst. 2012, 8, 2166­2173

Bogdanov AJr., Mazzanti M, Castillo G, Bolotin E. Protected graft copolymer (PGC) in imaging and therapy: a platform for the delivery of covalently and non-covalently bound drugs. Theranostics 2012; doi:10.7150/thno.4070

Goergen, CJ, Chen HH, Bogdanov AJr, Sosnovik DE, Kumar ATN. In vivo fluorescence lifetime detection of an activatable probe in infarcted myocardium. J. Biomed. Opt. 2012, 17(5) 056001 (May 2012).

Reichstetter S, Castillo GM, Lai M, Nishimoto-Ashfield A, Banerjee A, Bogdanov A, Lyubimov AV, Bolotin EM. Protected graft copolymer (PGC) basal formulation of Insulin as potentially safer alternative to Lantus® (Insulin-Glargine): a streptozotocin-induced, diabetic Sprague-Dawley rats study. Pharm Res. 2012, 29:1033-9.

Kang HW, Gupta S, Bogdanov A Jr.Orthotopic Expression of Noggin Protein in Cancer Cells Inhibits Human Lung Carcinoma Growth In Vivo. Mol Imaging Biol. 2012 14:480-488

Shazeeb M, Xie Y, Gupta S, Bogdanov AJr. A novel paramagnetic substrate for detecting myeloperoxidase activity in vivo. Mol Imaging 2012, 11, 1536-0121.

Medarova Z, Greiner DL, Ifediba M, Dai G, Bolotin E, Castillo G, Bogdanov A, Kumar M, Moore A. Diabetes Metab Res Rev. 2011 27:767-72

Metelev V, Zhang S, Tabatadze D, Bogdanov A.Hairpin-like fluorescent probe for imaging of NF-kB transcription factor activity. Bioconjug Chem. 2011 22:759-65.

Bogdanov A Jr, Mazzanti ML. Molecular magnetic resonance contrast agents for the detection of cancer: past and present. Semin Oncol. 2011 38: 42-54.

Shazeeb MS, Sotak CH, DeLeo M 3rd, Bogdanov A Jr.Targeted signal-amplifying enzymes enhance MRI of EGFR expression in an orthotopic model of human glioma. Cancer Res. 2011 71: 2230-9.

Kang HW, Walvick R, Bogdanov A Jr. In vitro and In vivo imaging of antivasculogenesis induced by Noggin protein expression in human venous endothelial cells. FASEB J. 2009, 23: 4126-34.

Ronald JA, Chen JW, Chen Y, Hamilton AM, Rodriguez E, Reynolds F, Hegele RA, Rogers KA, Querol M, Bogdanov A, Weissleder R, Rutt BK. Enzyme-sensitive magnetic resonance imaging targeting myeloperoxidase identifies active inflammation in experimental rabbit atherosclerotic plaques. Circulation. 2009, 120:592-9.

Zhang S, Bogdanov A. Plate Capture Assay of Fluorescent Oligonucleotide Duplex Reporter-Transcription Factor Complexes. Bioconjug Chem. 2009, 20:1444-48

Deleo MJ 3rd, Gounis MJ, Hong B, Ford JC, Wakhloo AK, Bogdanov AA Jr. Carotid Artery Brain Aneurysm Model: In Vivo Molecular Enzyme-specific MR Imaging of Active Inflammation in a Pilot Study. Radiology. 2009, 252:696-703.

Kim YR, Tejima E, Huang S, Atochin DN, Dai G, Lo EH, Huang PL, Bogdanov A Jr, Rosen BR. In vivo quantification of transvascular water exchange during the acute phase of permanent stroke. Magn Reson Med. 2008, 60:813-21.

Querol M, Bogdanov A Jr.Environment-sensitive and enzyme-sensitive MR contrast agents. Handb. Exp.Pharmacol. 2008, 185(Pt 2) 37-57.

Zhang S, Metelev V, Tabatadze D, Zamecnik P, Bogdanov A Jr. Near-infrared fluorescent oligonucleotides reporters for sensing NF-kappaB interactions in vitro. Oligonucleotides 2008, 18 : 235-43.

Zhang S, Metelev V, Tabatadze D, Zamecnik P, Bogdanov A Jr. Fluorescence resonance energy transfer in near-infrared fluorescent oligonucleotide probes for detecting protein-DNA interactions. Proc. Natl.Acad Sci USA 2008 105: 4156-4161.

Bogdanov, A Jr. Merging molecular imaging and RNA interference: Early experience in live animals. J Cell Biochem 2008 104:113-23.

Tabatadze D, Zamecnik P, Yanachkov I, Wright G, Pierson K, Zhang S, Bogdanov A Jr., Metelev V. A novel thymidine phosphoramidite synthon for incorporation of internucleoside phosphate linkers during automated oligodeoxynucleotide synthesis. Nucleosides Nucleotides Nucleic Acids 2008 27:157-72.

Querol M, Bennett DG, Sotak C, Kang, HW, Bogdanov A Jr. A Paramagnetic Contrast Agent for Detecting Tyrosinase Activity. Chembiochem 2007 8: 1637-41.

Medarova Z, Castillo G, Dai G, Bolotin E, Bogdanov A, Moore A. Non-invasive Magnetic Resonance Imaging of Microvascular Changes in Type 1 Diabetes. Diabetes. 2007 56:2677-82.

Bogdanov A Jr, Kang HW, Querol M, Pretorius PH, Yudina A. Synthesis and testing of a binary catalytic system for imaging of signal amplification in vivo. Bioconjug Chem. 2007 18:1123-30.

Bogdanov AA Jr, Lin CP, Kang HW. Optical imaging of the adoptive transfer of human endothelial cells in mice using anrti-CD31 monoclonal antibody. Pharm Res 2007 24:1186-1192.

Laguillier C, Hbibi AT, Baran-Marszak F, Metelev V, Cao A, Cymbalista F, Bogdanov A Jr, Fagard R.Cell death in NF-kappaB-dependent tumour cell lines as a result of NF-kappaB trapping by linker-modified hairpin decoy oligonucleotide. FEBS Lett. 2007 581:1143-50.

Querol M, Bogdanov, A Jr. Amplification strategies in MR imaging: activation and accumulation of sensing contrast agents (SCAs). J Magn Reson Imaging 2006, 24:971-982

Raman V, Artemov D, Pathak AP, Winnard PT Jr, McNutt S, Yudina A, Bogdanov A Jr, Bhujwalla ZM. Characterizing vascular parameters in hypoxic regions: a combined magnetic resonance and optical imaging study of a human prostate cancer model. Cancer Res 2006, 66:9929-9936.

Kang HW, Torres D, Wald L, Weissleder R, Bogdanov A Jr. Targeted imaging of human endothelial-specific marker in a model of adoptive cell transfer. Lab Invest 2006, 86:599-609.

Chen JW, Querol Sans M, Bogdanov, A Jr, Weissleder R. Imaging inflammation: a multimodality molecular imaging approach targeting myeloperoxidase. Radiology 2006, 240:473-481.

Runnels JM, Zamitri P, Spencer JA, Veilleux I, Wei X, Bogdanov A, Lin CP. Imaging molecular expression on vascular endothelial cells by in vivo immunofluorescence microscopy. Mol Imaging 2006, 5:31-40.

Querol M, Chen JW, Bogdanov A Jr. A paramagnetic contrast agent with myeloperoxidase-sensing propertiesOrg Biomol Chem, 2006, 4:1887-1895.

Banerjee P. Weissleder R. Bogdanov A Jr. Linear polyethyleneimine grafted to a hyperbranched poly(ethylene glycol)-like core: a copolymer for gene delivery. Bioconj. Chem. 2006 17:125-31.

Querol M, Chen JW, Weissleder R, Bogdanov A Jr. Myeloperoxidase activity imaging using 67-Ga labeled substrate. Molecular Imaging Biol. 2005, 7:403-410.

Kim, YR, Petrovsky A, Reichardt W, Hu-Lowe D, Kang HW, Torres D, Weissleder R, Bogdanov A Jr. Detection of early anti-angiogenic effects: in vivo changes of tumor blood volume in response to the experimental VEGF-receptor tyrosine kinase inhibitor. Cancer Res. 2005, 65: 9223-9260.

Reichardt W, Hu-Lowe D, Torres D, Weissleder R, Bogdanov A Jr. Imaging of VEGF receptor kinase inhibitor ­ induced anti-angiogenic effects in drug-resistant human adenocarcinoma model. Neoplasia 2005, 7:847-853.

Querol M, Chen JW, Weissleder R, Bogdanov A Jr. DTPA-bis-amide based MR sensor agents for peroxidase imaging. Org Lett 2005, 17: 1719-1722.

Wunder A, Schellenberger E, Mahmood U, Bogdanov, A Jr, Mueller-Ladner U, Weissleder R, Josephson L. Methotrexate-induced accumulation of fluorescent annexin V in collagen-induced arthritis Mol. Imag. 2005, 4: 1-5.

Choi HK, Yessayan D, Choi HJ, Schellenberger E, Bogdanov A, Josephson L, Weissleder R, Ntziachristos V Quantitative analysis of chemotherapeutic effects in tumors using in vivo staining and correlative histology. Cell Oncol 2005, 27:183-190.

Bogdanov AA Jr, Chen JW, Kang HW, Weissleder R. Magnetic resonance signal amplification probes. Ernst Schering Res Found Workshop. 2005;(49):147-57. Review.

Kim YR, Savellano MD. Savellano D, Weissleder R, Bogdanov A Jr. Measurement of tumor interstitial volume fraction: method and implication for drug delivery. Magn. Reson.Med. 2004 52: 485-494.

Ntziachristos V, Schellenberger EA , Ripoll J , Yessayan D , Graves E, Bogdanov, A Jr. , Josephson L Weissleder R. Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V­Cy5.5 conjugate. Proc Natl Acad Sci USA 2004 101: 12294-12299

Banerjee P, Weissleder R, Bogdanov A Jr. Novel hyperbranched dendron for gene transfer in vitro and in vivo. Bioconj Chem 2004, 15:960-968.

Metelev V, Weissleder R, Bogdanov A Jr. Synthesis and properties of fluorescent NF-kB recognizing hairpin oligodeoxynucleotide decoys. Bioconj Chem. 2004 15:1481-1487.

Chen JW, Pham W, Weissleder R, Bogdanov A Jr. Human myeloperoxidase: a potential target for molecular MR imaging in atherosclerosis. Magn Reson Med 2004, 52: 1021-1028.