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Recent Publications

Fall 2010

On-chip activation and subsequent detection of individual antigen-specific T cells. Song Q, Han Q, Bradshaw EM, Kent SC, Raddassi K, Nilsson B, Nepom GT, Hafler DA, Love JC. Anal Chem. 2010 Jan 15;82(2):473-7.PMID: 20000848

Evaluating the intrinsic cysteine redox-dependent states of the A-chain of human insulin using NMR spectroscopy, quantum chemical calculations, and mass spectrometry. Sharma AK, Ling Y, Greer AB, Hafler DA, Kent SC, Zhang Y, Rigby AC. J Phys Chem B. 2010 Jan 14;114(1):585-91.PMID: 19954153

Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells. Bradshaw EM, Raddassi K, Elyaman W, Orban T, Gottlieb PA, Kent SC, Hafler DA. J Immunol. 2009 Oct 1;183(7):4432-9. Epub 2009 Sep 11.PMID: 19748982

TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. Hastings WD, Anderson DE, Kassam N, Koguchi K, Greenfield EA, Kent SC, Zheng XX, Strom TB, Hafler DA, Kuchroo VK. Eur J Immunol. 2009 Sep;39(9):2492-501.PMID: 19676072

Evasion of peptide, but not lipid antigen presentation, through pathogen-induced dendritic cell maturation. Hava DL, van der Wel N, Cohen N, Dascher CC, Houben D, León L, Agarwal S, Sugita M, van Zon M, Kent SC, Shams H, Peters PJ, Brenner MB. Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11281-6. Epub 2008 Aug 6.PMID: 18685099

Multiple endocrine neoplasia type 1 deletion in pancreatic alpha-cells leads to development of insulinomas in mice. Shen HC, Ylaya K, Pechhold K, Wilson A, Adem A, Hewitt SM, Libutti SK. Endocrinology. 2010 Aug;151(8):4024-30. Epub 2010 Jun 16.PMID: 20555035

Transcriptional analysis of intracytoplasmically stained, FACS-purified cells by high-throughput, quantitative nuclease protection. Pechhold S, Stouffer M, Walker G, Martel R, Seligmann B, Hang Y, Stein R, Harlan DM, Pechhold K. Nat Biotechnol. 2009 Nov;27(11):1038-42. Epub 2009 Oct 18.PMID: 19838197

Transduction of rat pancreatic islets with pseudotyped adeno-associated virus vectors. Craig AT, Gavrilova O, Dwyer NK, Jou W, Pack S, Liu E, Pechhold K, Schmidt M, McAlister VJ, Chiorini JA, Blanchette-Mackie EJ, Harlan DM, Owens RA. Virol J. 2009 May 18;6:61.PMID: 19450275

Deciphering von Hippel-Lindau (VHL/Vhl)-associated pancreatic manifestations by inactivating Vhl in specific pancreatic cell populations. Shen HC, Adem A, Ylaya K, Wilson A, He M, Lorang D, Hewitt SM, Pechhold K, Harlan DM, Lubensky IA, Schmidt LS, Linehan WM, Libutti SK. PLoS One. 2009;4(4):e4897. Epub 2009 Apr 2.PMID: 19340311

Blood glucose levels regulate pancreatic beta-cell proliferation during experimentally-induced and spontaneous autoimmune diabetes in mice. Pechhold K, Koczwara K, Zhu X, Harrison VS, Walker G, Lee J, Harlan DM. PLoS One. 2009;4(3):e4827. Epub 2009 Mar 16.PMID: 19287497

Leptin treatment confers clinical benefit at multiple stages of virally induced type 1 diabetes in BB rats. Kruger AJ, Yang C, Lipson KL, Pino SC, Leif JH, Hogan CM, Whalen BJ, Guberski DL, Lee Y, Unger RH, Greiner DL, Rossini AA, Bortell R. Autoimmunity. 2010 Aug 9. [Epub ahead of print]PMID: 20695765

The mannose receptor mediates the uptake of diverse native allergens by dendritic cells and determines allergen-induced T cell polarization through modulation of IDO activity. Royer PJ, Emara M, Yang C, Al-Ghouleh A, Tighe P, Jones N, Sewell HF, Shakib F, Martinez-Pomares L, Ghaemmaghami AM. J Immunol. 2010 Aug 1;185(3):1522-31. Epub 2010 Jul 7.PMID: 20610655

Human Immune System Development and Rejection of Human Islet Allografts in Spontaneously Diabetic NOD-Rag1null IL2r{gamma}null Ins2Akita Mice. Brehm MA, Bortell R, Diiorio P, Leif J, Laning J, Cuthbert A, Yang C, Herlihy M, Burzenski L, Gott B, Foreman O, Powers AC, Greiner DL, Shultz LD. Diabetes. 2010 Jun 22. [Epub ahead of print]PMID: 20570944

The mechanical properties of Drosophila jump muscle expressing wild-type and embryonic Myosin isoforms. Eldred CC, Simeonov DR, Koppes RA, Yang C, Corr DT, Swank DM. Biophys J. 2010 Apr 7;98(7):1218-26.PMID: 20371321

Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation. Brehm MA, Cuthbert A, Yang C, Miller DM, DiIorio P, Laning J, Burzenski L, Gott B, Foreman O, Kavirayani A, Herlihy M, Rossini AA, Shultz LD, Greiner DL. Clin Immunol. 2010 Apr;135(1):84-98. Epub 2010 Jan 21.PMID: 20096637

Spring 2010

Humanized mouse models to study human diseases. Brehm MA, Shultz LD, Greiner DL., Curr Opin Endocrinol Diabetes Obes. 2010 Apr;17(2):120-5. view abstract on PubMed

NOD-scid IL2rgamma(null) mouse model of human skin transplantation and allograft rejection. Racki WJ, Covassin L, Brehm M, Pino S, Ignotz R, Dunn R, Laning J, Graves SK, Rossini AA, Shultz LD, Greiner DL., Transplantation. 2010 Mar 15;89(5):527-36. view abstract on PubMed

Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation. Brehm MA, Cuthbert A, Yang C, Miller DM, DiIorio P, Laning J, Burzenski L, Gott B, Foreman O, Kavirayani A, Herlihy M, Rossini AA, Shultz LD, Greiner DL., Clin Immunol. 2010 Apr;135(1):84-98. Epub 2010 Jan 21. view abstract on PubMed

Transcriptional analysis of intracytoplasmically stained, FACS-purified cells by high-throughput, quantitative nuclease protection. Pechhold S, Stouffer M, Walker G, Martel R, Seligmann B, Hang Y, Stein R, Harlan DM, Pechhold K. Nat Biotechnol. 2009 Nov;27(11):1038-42. Epub 2009 Oct 18. view abstract on PubMed

Blood glucose levels regulate pancreatic beta-cell proliferation during experimentally-induced and spontaneous autoimmune diabetes in mice. Pechhold K, Koczwara K, Zhu X, Harrison VS, Walker G, Lee J, Harlan DM., PLoS One. 2009;4(3):e4827. Epub 2009 Mar 16. view abstract on PubMed

Current advances and travails in islet transplantation. Harlan DM, Kenyon NS, Korsgren O, Roep BO; Immunology of Diabetes Society., Diabetes. 2009 Oct;58(10):2175-84. view abstract on PubMed

CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells. Pino SC, O'Sullivan-Murphy B, Lidstone EA, Yang C, Lipson KL, Jurczyk A, diIorio P, Brehm MA, Mordes JP, Greiner DL, Rossini AA, Bortell R., PLoS One. 2009;4(5):e5468. Epub 2009 May 8. view abstract on PubMed

 
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