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Dr. Clifford Rosen Presented at UMass Endocrine Grand Rounds and Remembered Longtime Mentor and Friend Dr. Lewis E. Braverman

Video below of his 9/22/20 talk "A New Counter-Regulatory Hormone During Exercise: The Story of Irisin"

Date Posted: Wednesday, September 23, 2020
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Clifford Rosen, MD


The UMass Diabetes Center of Excellence (DCOE) and Division of Endocrinology welcomed Clifford Rosen, MD, to present at Endocrine Grand Rounds. Dr. Rosen is the director of clinical and translation research at Maine Medical Center Research Institute, and professor of medicine at Tufts University School of Medicine.

He was the first editor-in-chief of the Journal of Clinical Densitometry, is the current editor-in-chief of The Primer in Metabolic Bone Diseases, and Associate Editor for New England Journal of Medicine. His publications include nearly 400 peer-reviewed manuscripts covering both clinical and basic bone biology. Dr. Rosen has overseen numerous phase II and III clinical trials.   


His talk was delivered to dozens of UMass Memorial diabetes and endocrinology care team members, as well as scientists and lab members from throughout UMass Medical School, whose research focuses on diabetes and metabolism. Dr. Rosen spoke about the effects of a hormone called irisin, and how irisin levels increase after exercise and affect bone remodeling. He also discussed the reported effects of irisin on fat metabolism and browning of white adipose cells. Both the Czech Lab and the Corvera Lab at the UMass DCOE are working to translate their basic science discoveries about beige/brown fat and adipose tissue manipulation into therapies for diabetes, neuropathy and obesity.

Dr. Rosen’s ties to UMass Medical Center date back to his medical residency during the late 1970’s, where a long friendship and working relationship was formed with the late Dr. Lewis Braverman.   

Lewis Braverman, MD

Among the many impressive titles and responsibilities held by Dr. Braverman throughout his distinguished career, he founded the Endocrinology and Diabetes Division at UMass Medical School, and personally developed the clinic at UMass Memorial Medical Center. 

"He was a superb physician in addition to a really good clinical researcher," said Dr. Neil Aronin, director of endocrinology and metabolism at UMass Medical School. "But he also loved to teach and interact with medical students."

Dr. Braverman left an impressive legacy in the thyroid field, including more than 600 publications in many leading clinical and research medical journals.


More importantly to many are the dozens of fellows he directly mentored and the hundreds of others who passed through his laboratory and clinic throughout his career. 

"It was his passion for mentoring fellows, students and junior faculty that most defined Dr. Braverman and truly places him among the giants," wrote Alan P. Farwell, MD, chief of endocrinology, diabetes & nutrition at Boston University School of Medicine, in a touching in memoriam published in Clinical Thyroidology. Dr. Farwell was a student at UMass Medical School and completed his endocrinology fellowship at UMass. He would later serve as outpatient clinic director at UMass Memorial prior to his current position in Boston.

“Lew Braverman was a real force at UMass Medical School when I arrived in 1981, and he continued to be an amazing stalwart of the academic enterprise here,” said Michael P. Czech, PhD, the Isadore and Fannie Foxman Chair in Medical Research and professor of molecular medicine. “He was an admirable role model for doing impactful research and being a champion of the academic core values that guide both physician and basic scientists.”

Dr. Rosen remembered his dear friend who he met "when I was just a poor intern" at Berkshire Medical Center, where Dr. Braverman inspired him to do an Endocrine Fellowship. They remained good friends as Dr. Rosen set up his practice and began clinical research in Bangor, Maine. Since their institutions were already collaborating, Dr. Braverman invited the young clinician/scientist to make the two and a half hour drive each Tuesday to UMass Medical School to attend Endocrine Grand Rounds and "continue my enrichment."

Their relationship continued until the passing of Dr. Braverman at age 90 on June 10, 2019. More than four decades after their initial introduction, Dr. Rosen was the one presenting at UMass Medical’s Endocrine Grand Rounds as a well-respected expert in his field. 

Clifford J. Rosen, MD

"A New Counter-Regulatory Hormone During Exercise: The Story of Irisin"

Clifford Rosen, MD - Irisin