Amy K. Walker, PhD

Associate Professor, Program in Molecular Medicine
University of Massachusetts Medical School


BS in Microbiology, Auburn University, Auburn, Alabama
PhD in Molecular Microbiology, State University of New York at Stonybrook

Our Diabetes Research

Our lab examines links between metabolism and cellular function potentially contributing to human metabolic disorders including diabetes.

Using C. elegans and mammalian models, we investigate how lipid homeostasis is affected by genetics or diet and how transcriptional control of methyl donor supply may affect cellular processes such as epigenetics.  

We also study how metabolites act as signals to control gene expression and lipid accumulation.

Selected Publications

Ding W, Higgins DP, Yadav DK, Godbole AA, Pukkila-Worley R, Walker AK. Stress-responsive and metabolic gene regulation are altered in low S-adenosylmethionine. PLoS Genet. 2018 Nov 28; 14(11):e1007812. PMID: 30485261.
Walker AK. 1-Carbon Cycle Metabolites Methylate Their Way to Fatty Liver. Trends Endocrinol Metab. 2017 Jan; 28(1):63-72. PMID: 27789099.
Ding W, Smulan LJ, Hou NS, Taubert S, Watts JL, Walker AK. s-Adenosylmethionine Levels Govern Innate Immunity through Distinct Methylation-Dependent Pathways. Cell Metab. 2015 Oct 06; 22(4):633-45. PMID: 26321661.
Amy K Walker & Anders M Näär. Clinical Lipidology. SREBPs: regulators of cholesterol/lipids as therapeutic targets in metabolic disorders, cancers and viral diseases. 2012; 1(7):27-36.