Reichert CS Auto freeze-substitution apparatus

When the ultimate in ultrastructural preservation of tissues or cells is required, with minimal artifacts from specimen preparation, tissues or cells can be ultra-rapidly frozen against a ‘metal mirror’ cooled with liquid helium.  Following freezing, specimens are fixed at low temperature (stabilizing cellular components) in a process known as freeze-substitution.  They are then embedded and sectioned in the normal way.  The facility possesses the capability both for the rapid freezing and the freeze substitution.  The Reichert CS auto allows for precise programming of controlled temperature changes during the cryo-substitution process.