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Philips CM120 Cryo-Electron Microscope

Phillips CM 120

Philips CM120 cryo-electron microscope is a computer-controlled transmission instrument dedicated to low dose and cryo-electron microscopic observations. Low electron dose images minimize specimen damage due to electron irradiation, thus enhancing molecular level detail in negative stain and cryo images. The facility possesses plunge-freezing equipment for specimen preparation and a Gatan cryo-holder for specimen observations at temperatures of ~ -185o C. An integral part of the microscope is the computer-controlled goniometer ‘CompuStage’, allowing storage and recall of multiple specimen positions, greatly aiding in cryo-observation. The CM120 is equipped with two CCD digital cameras. A Tietz 2Kx2K CCD camera and a fiber optically coupled Gatan Orius 832 camera for direct digital acquisition of images. The Tietz software allows automated collection of multiple tilt images for electron tomography. A Fischione Advanced Tomography holder allows tilts up to ±60C.