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Jason Shohet, MD, PhD

Research Focus - Translational Therapeutics for Neuroblastoma and Other Aggressive Pediatric Solid Tumors

  • Use of humanized mice (avatars) to model tumor-immune interactions and therapeutic responses
  • Study of neuroblastoma cancer stem cells and tumor heterogeneity
  • Elucidation of the role of MYCN and c-Myc oncogene in neuroblastoma and other pediatric solid tumors

Representative Publication

Agarwal S, Lakoma A, Chen Z, et al. G-CSF promotes neuroblastoma tumorigenicity and metastasis via STAT3-dependent cancer stem cell activation. Cancer Res. 2015;75(12):2566-2579.

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In the News

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  • Jason Shohet receives second Hyundai Hope on Wheels grant
    Research News

    Jason Shohet receives second Hyundai Hope on Wheels grant

    Hyundai Hope on Wheels has awarded Jason Shohet, MD, PhD, a second $300,000 Scholar Hope Grant to continue his research on neuroblastoma, a deadly cancer in children that affects the peripheral nervous system.

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  • LISTEN: Innovations in pediatric cancer research at UMass Medical School
    Research News

    LISTEN: Innovations in pediatric cancer research at UMass Medical School

    In a new Voices of UMassMed podcast, Jason Shohet, MD, PhD, highlights new advances in pediatric cancer research at UMass Medical School, and Luis Portillo Reyes, a young cancer patient, opens up about going through treatment for leukemia. 

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  • Hyundai Hope on Wheels award supports Jason Shohet’s research in childhood cancer
    Research News

    Hyundai Hope on Wheels award supports Jason Shohet’s research in childhood cancer

    UMass Medical School clinician-scientist Jason Shohet, MD, PhD, accepted a $300,000 grant on Monday, Sept. 23, from the Hyundai Motor America Hope on Wheels campaign to continue his work toward developing more effective and less toxic therapies for childhood cancers with a special focus on neuroblastoma.

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    Symposium for caregivers of pediatric cancer survivors April 22 at UMMS

    UMass Medical School and UMass Memorial Medical Center are hosting the biannual Consortium for New England Childhood Cancer Survivors for its members from all 13 pediatric oncology programs from all six New England states.

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  • Physician-scientist Jason Shohet researches path to better childhood cancer therapies
    Media, Our Experts, Research News

    Physician-scientist Jason Shohet researches path to better childhood cancer therapies

    Jason Shohet, MD, PhD, is focused on developing more effective and less toxic therapies for childhood cancers with a special focus on neuroblastoma.

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  • 2018 Investiture Ceremony honors four named professors and their benefactors
    Community News

    2018 Investiture Ceremony honors four named professors and their benefactors

    Jane Freedman, MD; Jonathan Gerber, MD; Jason Shohet, MD, PhD; and Zhiping Weng, PhD; were officially invested into named professorships at the 2018 Investiture Ceremony on Thursday, Sept. 13, bringing the total number of endowed chairs at UMass Medical School to 49.

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  • Four faculty members appointed to endowed professorships
    Community News

    Four faculty members appointed to endowed professorships

    Four faculty members have been appointed to endowed professorships at UMass Medical School in recognition of their contributions to biomedical research, education and patient care. Each will be formally invested Sept. 13 at the Convocation and Investiture ceremony.

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  • UMass Cancer Walk turns 20 in September
    Community News

    UMass Cancer Walk turns 20 in September

    The UMass Cancer Walk and Run will celebrate its 20th anniversary this September. Sponsors and fundraising team leaders gathered on campus on Wednesday, June 20, to meet with cancer researchers and clinicians, tour cancer research labs, and get to work on the event’s ambitious goal of raising $750,000 this year.

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