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Jaime Rivera, PhD

Research Focus - Morphogenetic and Molecular Analysis of Early Mammalian Development

  • Understand the key regulators that shape the mouse embryo at stages that encompass the first ten days of development, a period of embryogenesis when totipotent and pluripotent cells make decisions about lineage commitment and differentiation
  • Investigate the role of the Wnt signaling pathway in axial specification and gastrulation
  • Study the development of tissues at the maternal-fetal interphase such as the yolk sac and the placenta
  • Use mouse models to understand the developmental mechanisms that lead to the etiology of Down Syndrome
  • Develop novel technologies that facilitate the study of mammalian embryos, in particular the use of adeno-associated virus vectors and CRISPR-Cas9 components to generate gene-edited mice in vivo

Representative Publication

Yoon Y, Wang D, Tai PWL, Riley J, Gao G, Rivera-Pérez JA. Streamlined ex vivo and in vivo genome editing in mouse embryos using recombinant adeno-associated viruses. Nat. Commun. 2018;9(1):412.

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