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Mario Stevenson

UMassMed Faculty Page

Inventions:

Title: METHODS OF MONITORING TREATMENT EFFECTIVENESS IN HIV-INFECTED PATIENTS RECEIVEING INTENSIFIED HAART REGIMENS BY MEASURING EPISOMAL 2-LTR CIRCLES. UMMS09-39; Patent 8,748,088

  • This patented invention provides methods for detecting the presence of replication-competent HIV-1 virus in a subject who is being treated with an intensified highly active anti-retroviral therapy (HAART) regimen. These methods comprise obtaining a blood sample, specifically amplifying a segment spanning two-long terminal repeat (2-LTR) junction of 2-LTR circles using PCR and determining the presence of replication competent virus based on the level of 2-LTR circles in the sample. These methods can be used to monitor an intensified HAART regimen by obtaining samples from the same subject at different time points during the HAART treatment, and comparing levels of the 2-LTR circles in those samples.

Title: Detection of Human Immunodeficiency Virus. UMMS08-36; Patent Pending. 

  • This new PCR based assay can detect cells that have been recently infected by HIV, even those that may not typically be detectable while the patient is under aggressive antiretroviral therapy. In peripheral blood lymphocytes, this method detects circular viral DNA in individuals infected with HIV. This detection method has been found effective even when plasma viral RNA levels are undetectable under conventional HIV RNA-PCR testing. Research on this method also revealed that the currently implemented treatment with antiretroviral agents does not completely abolish the viral infection, providing an opportunity for further innovation in HIV management.

 

Innovation TopicsDiagnosticsInfectious DiseaseHIV