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Christopher Sassetti

UMassMed Faculty Page

Inventions:

Title: A New Approach to Accelerate Antibiotic Action. UMMS10-30; Patent Pending.

  • This is a novel method to increase the efficacy of antibiotics by targeting bacterial central metabolism. The UMass Medical School inventors identified 38 metabolic targets, inhibition of which with concurrent antibiotic treatment can synergistically kill slow-growing dormant Mycobacterium tuberculosis (Mtb), the agent of human tuberculosis. These slow-growing bacterial populations are challenging to eradicate because they are refractory to antibiotic treatment. Inhibiting Mtb central metabolism enables more thorough treatment of tuberculosis infection and may be applicable to other infectious diseases. 

  

Innovation TopicsSmall MoleculesInfectious DiseaseMycobacterium tuberculosisAntibiotics/Antibiotic treatment