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Evelyn A Kurt-Jones

UMassMed Faculty Page

Inventions:

Title: An IFN╬▓ Reporter Cell Line, clone SZ34. UMMS12-01; Patent Pending.  

  • Large-scale and high throughput screen for compounds that module type I interferons identify potential therapeutics that block viral replication. Clone SZ34 is a stabilly transfected human embryonic kidney cell (HEK) with expression plasmids for an IFN-Beta-promoter-driven firefly luciferase reporter gene (IFN-Beta-Luc). 

Title: COMPOUNDS FOR MODULATING TLR2. UMMS09-52 Patent 8,609,6639,271,972

  • Viral infection causes damage to the host via stimulation of production of host cytokines. These processes can culminate in edema and damage to host organs. From screening, this novel invention identifies molecules that could potentially inhibit the cytokine response to viral infection by inhibiting RNA virus-mediated TNF-alpha production. The current invention discloses methods of the system used to screen, a TLR2 and CD14 stable cell line, and molecular inhibitors of Lymphocytic Choriomeningitis Virus (LCMV) induced cytokine production. These newly discovered molecules may facilitate amelioration of symptoms in a broad range of hemorrhagic fever viruses.

  

Innovation TopicsResearch Tools, AntiviralCell lineCell lineHigh throughput screeningVirologyInfectious DiseaseImmunologyImmune edemaHemorrhagic feverLymphocytic Choriomeningitis Virus (LCMV)