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Marc Freeman

UMassMed Faculty Page

Inventions:

Title: THERAPEUTIC APPLICATIONS TARGETING SARM1. UMMS11-10; Patent US9,486,521B2

  • This novel patented technology provides methods of treating peripheral neuropathy, brain injury, and neurodegenerative disease utilizing an siRNA that inhibits sterile a/ Armadillo/To 11-Interleukin receptor homology domain protein (SARM) expression. This invention is based on the discovery that inhibition of SARM mRNA reduces axonal and synaptic degeneration in mice. The invention further provides methods of identifying potential therapeutic agents that modulate SARM.

 

Innovation Topics: RNAi/micro-RNA TherapyNeurologyNeurodegerative disorderNeuropathy