Theresa Broering

UMassMed Faculty Page

Inventions:

Title: Monoclonal Antibodies to sFlt1 and Uses Thereof. UMMS13-51; Patent Pending.

• This technology discloses novel antibodies and antibody fragments that bind soluble fms-like tyrosine kinase 1 (sFlt1) in an isoform specific manner. Further disclosed are assays employing sFlt1 antibodies to evaluate preeclampsia in pregnant women.

  • Technology: Diagnostics
    
  • Applications: Eclampsia/Preeclampsia, Obstetrics

Title: ANTI-SOD1 ANTIBODIES AND USES THEREOF. UMMS10-69; Patent 9,109,037

• This invention discloses a panel of newly discovered human monoclonal antibodies against human SOD1 protein.  There are two types of SOD1 antibodies available: 1) one that binds to all forms of SOD1 and 2) one that binds to the misfolded form of SOD1. Mutated SOD1 is associated with 20% of inheritable forms of Amyotrophic Lateral Sclerosis (ALS) and blocking its function is protective. These monoclonal antibodies present a unique therapeutic opportunity to treat ALS with an immunologically targeted approach. 

  • Technology: Biologics
  • Applications: Neuronal SOD1, Amyolateral Sclerosis (ALS), Human monoclonal, Antibody
  • Patent Expiration Dates: 2031-11-10

Innovation Topics: Diagnostics, Eclampsia/Preeclampsia, Obstetrics, Biologics, Neuronal SOD1, Amyolateral Sclerosis (ALS), Human monoclonal, Antibody