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Theresa Broering

UMassMed Faculty Page

Inventions:

Title: Monoclonal Antibodies to sFlt1 and Uses Thereof. UMMS13-51; Patent Pending.

  • This technology discloses novel antibodies and antibody fragments that bind soluble fms-like tyrosine kinase 1 (sFlt1) in an isoform specific manner. Further disclosed are assays employing sFlt1 antibodies to evaluate preeclampsia in pregnant women.

Title: ANTI-SOD1 ANTIBODIES AND USES THEREOF. UMMS10-69; Patent 9,109,037

  • This invention discloses a panel of newly discovered human monoclonal antibodies against human SOD1 protein.  There are two types of SOD1 antibodies available: 1) one that binds to all forms of SOD1 and 2) one that binds to the misfolded form of SOD1. Mutated SOD1 is associated with 20% of inheritable forms of Amyotrophic Lateral Sclerosis (ALS) and blocking its function is protective. These monoclonal antibodies present a unique therapeutic opportunity to treat ALS with an immunologically targeted approach. 

 

Innovation TopicsDiagnosticsEclampsia/PreeclampsiaObstetricsBiologicsNeuronal SOD1Amyolateral Sclerosis (ALS)Human monoclonalAntibody