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Daniel Bolon receives new NIH R21 award

Date Posted: Thursday, April 22, 2021


Investigating autoprocessing by HIV-1 protease 

Dan Bolon R21 awardAutoprocessing is the process by which viral protease cuts itself out of a polyprotein precursor. It is a critical early step in the infection cycle of many viruses including HIV-1 and SARS-CoV-2, making it an appealing drug target. The Bolon lab and Schiffer labs will combine their expertise in deep mutational scanning and drug resistance to investigate how protein sequence and inhibitor structure impact autoprocessing by HIV-1.  


For more about the Bolon Lab, please visit www.umassmed.edu/bolonlab
For more about the Schiffer Lab, please visit www.umassmed.edu/schifferlab