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Massi and Ryder labs awarded R01 from the National Institute of General Medical Sciences

Date Posted: Thursday, October 15, 2020


Massi RyderThe Massi and Ryder labs were awarded a multiple PI R01 award from the National Institute of General Medical Sciences to study the activity of the C. elegans RNA binding proteins OMA-1/2 from structure to phenotype. OMA-1/2 initiate a cascade of events that is essential to the oocyte-to-embryo transition in C. elegans. Loss-of-function mutations in OMA-1/2 block oocyte maturation and prevent fertilization. The goal of this study is to understand how the molecular properties of OMA-1/2 determine their mRNA regulatory function. By understanding the mechanisms that regulate mRNAs during the oocyte-to-embryo transition this research will identify how this control is tied to the development of living cells and will ultimately provide insights into the molecular basis of congenital developmental diseases. 



For more about the Massi Lab, please visit www.umassmed.edu/massilab

For more about the Ryder Lab, please visit www.umassmed.edu/ryderlab