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Elisabet Mandon, PhD, continues research at Horae Gene Therapy Center

Date Posted: Monday, June 03, 2019

Dr. Elisabet MandonOn Friday, May 24th, we celebrated the successful career of BMP researcher and faculty member, Elisabet Mandon, PhD, as she continues and moves her research to the Horae Gene Therapy Center working for Dr. Guangping Gao.

Dr. Mandon started her career at UMass Medical School when the department was simply called Biochemistry. Beginning in 1998, she worked with Dr. Reid Gilmore focusing her research on understanding how proteins reach their final destination in the cell and, over the last four years, on dissecting the mechanisms in which altering the protein delivery provokes disease.

As Dr. Gilmore is preparing for his retirement, Dr. Mandon is looking forward to continuing her important research within a new department here at the University of Massachusetts Medical School.  This move across campus will allow Dr. Mandon to continue to collaborate and expand upon her ongoing research with existing and new colleagues. 

BMP wishes Elisabet well as she continues her research and thanks her for her dedication and service to our Department. 

Dr. Mandon details more about her research:

Gunter Blobel’s seminal discovery of the signal sequence’s role in protein delivery to organelles left a lot of open questions about how the different partners in this process interact, and about how it is regulated. Initially, we demonstrated that one of the partners (Sec61 complex) regulates the delivery of the signal sequence by facilitating GTP hydrolysis of two other partners, the signal recognition particle (SRP) and the SRP receptor (SR). Then, we continued with the identification of which specific protein regions are interacting and how, at the atomic level. Finally, in collaboration with Roland Beckmann’s group in Germany, we were able to literally see these machineries using electron microscopy.

After understanding how these complex structures work together, I will embark in my new appointment at the Horae Gene Therapy Center with the quest to understand the mechanisms that modulate them to preserve the homeostasis that supports normal life.