Dynamic changes in copper homeostasis and post-transcriptional regulation of Atp7a during myogenic differentiation

Date Posted: Monday, March 05, 2018

The Padilla lab reported for the first time the cellular requirement for Cu for both proliferation and differentiation of primary myoblasts. They have also established the basis for understanding the network of Cu transport associated with myogenesis. Importantly, they showed that a key Cu homeostasis gene, Atp7a, undergoes dynamic changes in expression during myogenic differentiation. Alternative polyadenylation and stability of Atp7a mRNA fluctuates with differentiation stage of the myoblasts, indicating post-transcriptional regulation of Atp7a that depends on the differentiation state.

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