Casein kinase 2–mediated phosphorylation of Brahma-related gene 1 controls myoblast proliferation and contributes to SWI/SNF complex composition

Figure 6. Phosphomimetic and non-phosphorylatable mutations in Brg1 or inhibition of CK2 affects intra-nuclear mobility and association with chromatin and the nuclear matrix. (A) Timecourse of representative confocal microscopy images from FRAP experiments performed on primary myoblasts expressing WT-, SA-, or SE-Brg1.


Dr. Tony Imbalzano and Dr. Teresita Padilla-Benavides published a paper in the Journal of Biological Chemistry.  In this paper, Dr. Imbalzano and Dr. Padilla-Benavides team show CK2- mediated phosphorylation of Brg1 regulate myoblast proliferation and provide insight into one mechanism by which composition of the mammalian SWI/SNF enzyme complex is regulated.

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