Casein kinase 2–mediated phosphorylation of Brahma-related gene 1 controls myoblast proliferation and contributes to SWI/SNF complex composition

Figure 6. Phosphomimetic and non-phosphorylatable mutations in Brg1 or inhibition of CK2 affects intra-nuclear mobility and association with chromatin and the nuclear matrix. (A) Timecourse of representative confocal microscopy images from FRAP experiments performed on primary myoblasts expressing WT-, SA-, or SE-Brg1.

 

Dr. Tony Imbalzano and Dr. Teresita Padilla-Benavides published a paper in the Journal of Biological Chemistry.  In this paper, Dr. Imbalzano and Dr. Padilla-Benavides team show CK2- mediated phosphorylation of Brg1 regulate myoblast proliferation and provide insight into one mechanism by which composition of the mammalian SWI/SNF enzyme complex is regulated.

Full Article: http://www.jbc.org/content/292/45/18592.full.pdf

About Dr. Imbalzano: https://www.umassmed.edu/imbalzanolab/

About Dr. Padilla-Benavides: https://www.umassmed.edu/padillalab/