EUREKA! NIH funds paternal epigenetic inheritance

Date Posted: 11/15/09

Dr. Oliver RandoThe passage of genetic information from one generation to the next allows for the propagation of a species. While nucleic acids provide relative genetic stability, it takes years, if not millennia, for the genetic code of a species to adapt to abrupt changes in the environment. Assistant Professor Ollie Rando believes epigenetic inheritance, the passage from parents to children of information above and beyond DNA sequence, provides a more rapid means to adapt to new environments. To directly test his hypotheses, Professor Rando was awarded an NIH EUREKA (“Exceptional, Unconventional Research Enabling Knowledge Acceleration”) grant. With this 4-year award, the Rando laboratory will determine whether pre-conditioned male mice can pass epigenetic information to their progeny, providing their children with a significant growth advantage during times of stress or changed food supplies.

For more information about Dr. Rando’s research program, click here.