CDKN2A/B T2D Genome-Wide Association Study Risk SNPs Impact Locus Gene Expression and Proliferation in Human Islets

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Genetic studies have already linked a region of the human genome called CDKN2A/B with the risk of type 2 diabetes, but how and why it increases T2D risk remains unknown. Our research, funded by a grant by the American Diabetes Association in collaboration with the Order of the Amaranth, took an in-depth look at the specific and subtle ways that these genes impact the insulin-producing pancreatic beta cells.  READ MORE

Boston Ithaca Islet Club Annual Meeting

Laura Alonso, MD

Our Lab was honored to host the 26th BIIC Annual Meeting at the UMass Diabetes Center of Excellence.  The Boston Ithaca Islet Club is a longstanding tradition in the Northeast region, founded and maintained by a group of top scientists in the islet field. Our 2-day annual meeting was an open forum, with talks on unpublished, cutting-edge work from trainees and students through principal investigators. 


Partial clinical remission in type 1 diabetes: a comparison of the accuracy of total daily dose of insulin of <0.3 units/kg/day to the gold standard insulin-dose adjusted hemoglobin A1c of ≤9 for the detection of partial clinical remission

It is unclear whether the gold standard test for the detection of partial clinical remission (PCR) in new-onset type 1 diabetes (T1D), the insulin-dose adjusted Hemoglobin A1c (IDAA1c) of ≤9, is superior to a new tool, total daily dose of insulin (TDD) of <0.3 units/kg/day.  The aim of this study was to test the superiority of IDAA1c over TDD of <0.3 units/kg/day for the detection of PCR.  READ MORE