CDKN2A/B T2D Genome-Wide Association Study Risk SNPs Impact Locus Gene Expression and Proliferation in Human Islets

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Genetic studies have already linked a region of the human genome called CDKN2A/B with the risk of type 2 diabetes, but how and why it increases T2D risk remains unknown. Our research, funded by a grant by the American Diabetes Association in collaboration with the Order of the Amaranth, took an in-depth look at the specific and subtle ways that these genes impact the insulin-producing pancreatic beta cells.  READ MORE

Boston Ithaca Islet Club Annual Meeting

Laura Alonso, MD

Our Lab was honored to host the 26th BIIC Annual Meeting at the UMass Diabetes Center of Excellence.  The Boston Ithaca Islet Club is a longstanding tradition in the Northeast region, founded and maintained by a group of top scientists in the islet field. Our 2-day annual meeting was an open forum, with talks on unpublished, cutting-edge work from trainees and students through principal investigators. 

Video Demonstration of Pancreatic Islet Embedding for Paraffin Sections

Experiments using isolated pancreatic islets are important for diabetes research, but islets are expensive and of limited abundance. Current frequently used methods to study cultured islets include molecular studies performed on whole islets, lumping disparate islet cell types together, or microscopy or molecular studies on dispersed islet cells, disrupting islet architecture. For in vivo islet studies, paraffin-embedded pancreas sectioning is a powerful technique to assess cell-specific outcomes in the native pancreatic environment.