Department of Medicine

Rheumatology Division

Research

 

Bonnie J. Bidinger, MDAssistant Professor of Medicine

Bidinger B., Torres R., Rossetti R.G., Brown L., Beltre R., Burstein S., Lian J.B., Stein G.S., Zurier R.B. Ajulemic acid, a nonpsychoactive cannabinoid acid, induces apoptosis in human T lymphocytes.   Clinical Immunology. 2003; 108:95-102. 

Zurier R.B., Rossetti R.G., Burstein S.H., Bidinger B.  Suppression of human monocyte interleukin-1ß production by ajulemic acid, a nonpsychoactive cannabinoid.   Biochemical Pharmacology. 2003; 65:649-655. 

Ellen Gravallese, MDProfessor of Medicine 

Pathogenic mechanisms of inflammatory arthritis, with a special interest in rheumatoid arthritis. 

Identification of cell types producing matrix metalloproteinase enzymes that destroy the extracellular matrix of cartilage in disease such as rheumatoid arthritis and pigmented villonodular synovitis, and the identification of pathways leading to bone destruction in rheumatoid arthritis.  

Focal bone erosions in rheumatoid arthritis and the relationship of articular and systemic bone loss.  

Leslie R. Harrold, MD, MPHAssociate Professor of Medicine 

Harrold LR, Yood RA, Mikuls TR, Andrade SE, Davis J, Fuller J, Chan KA, Roblin D, Raebel MA, Von Worley A, Platt R, Saag K.  Sex differences in gout epidemiology, evaluation and treatment.   Annals of Rheumatic Disease (in press). 

Harrold LR, Saag KG, Yood RA, Mikuls TR, Andrade SE, Fouayzi H, Davis J, Chan KA, Raebel MA, Von Worley A, Platt R.  Validity of gout diagnoses in administrative data.   Arthritis Care and Research (in press). 

Ann Marshak-Rothstein, PhD
 Professor of Medicine
Factors regulating T and B lymphocyte activation, function, longevity, and apoptosis, especially in animal models of systemic autoimmune disease.

Regulatory functions of Fas-ligand. Fas-ligand was originally identified as a pro-apoptotic transmembrane protein critically involved in the regulation of T cells by activation induced cell death.

Animal models of pseudo-GVHD in which TCR transgenic T cells are specifically targeted to either MHC class II+ cells or to the vascular endothelium.

Judith A. Stebulis, MDAssistant Professor of Medicine 

Mechanisms whereby nonpsychoactive antiinflammatory cannabinoid acids exert their effects. 

Robert B. Zurier, MDProfessor of Medicine 

Mechanisms of joint tissue injury. 

Exploration of influence of nonpsychoactive cannabinoid acids on immune/inflammatory reactions.