Publications

2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000

Li, C., Vagin, V.V., Lee, S., Xu, J., Ma, S., Xi, H., Seitz, H., Horwich, M.D., Syrzycka, M., Honda, B.M., Kittler, E.L.W., Zapp, M.L., Klattenhoff, C., Schulz, N., Theurkauf, W.E., Weng, Z., and Zamore, P.D. (2009). Collapse of germ-line piRNAs in the absence of Argonaute3 reveals somatic piRNAs in flies. Cell, 139 509-521.

Pfister, E.L., Kennington, L., Straubhaar, J., Wagh, S., Liu, W., DiFiglia, M., Landwehrmeyer, B., Vonsattel, J.-P., Zamore, P.D., and Aronin, N. (2009). Five siRNAs targeting three SNPs in Huntingtin may provide therapy for three-quarters of Huntington’s disease patients. Current Biology, in press.
  
 Ghildiyal, M., Zamore, P.D. (2009). Small Silencing RNAs: an expanding universe. Nature Review Genetics Feb;10(2)94-108.

Horwich, M.D. , Zamore, P.D.  (2008). Design and delivery of antisense oligonucleotides to block microRNA function in cultured Drosophila and human cells. Nature Protocols 3(10): 1537-49. 

Liu, W., Kennington, W.A., Rosas, H. D., Hersch, S., Cha, J.-H., Zamore, P.D., and Aronin, N. (2008). Linking SNP identity to CAG repeat length in Huntington's Disease patients. Nature Methods 5, 951-953 

 
Seitz, H., Ghildiyal, M., and Zamore, P.D. (2008). Argonaute loading contributes to the precision of the 5´ ends of both microRNAs and their miRNA* strands in flies. Current Biology 18, 147-151.

Ghildiyal, M., Seitz, H., Horwich, M.D., Li, C., Du, T., Lee, S, Xu, J., Kittler,E.L.W., Zapp, M.L., Weng, Z., and Zamore, P.D. (2008). Endogenous siRNAs derived from transposons and mRNAs in Drosophila somatic cells. Science 320,1077-1081. 

Matranga, C., and Zamore P.D. (2007). Primer: Small silencing RNAs. Current Biology 17, R789-93. 

Du, T., and Zamore, P.D. (2007). Beginning to understand microRNA function. Cell Research 8, 661-663. 

DiFiglia, M., Sena-Esteves, M., Chase, K., Sapp, E., Pfister, E., Sass, M., Yoder, J., Reeves, P., Pandey, R.K., Rajeev, K.G., Manoharan, M., Sah, D.W.Y., Zamore, P.D., and Aronin, N. (2007). Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits. PNAS 104, 17204-17209. 

Zamore, P.D. (2007). RNA silencing: genomic defence with a slice of pi. Nature 446, 864-5.

Tomari, Y., Du, Tingting, Zamore, P.D. (2007). Sorting of Drosophila small silencing RNAs. Cell 130, 299-308. 

Förstemann, K., Horwich, M.D., Wee, L., Tomari, Y., Zamore, P.D (2007).  Drosophila microRNAs are sorted into functionally distinct Argonaute protein complexes after their production by Dicer-1. Cell 130, 287-297. 

Horwich, M.D., Li, C., Matranga, C., Vagin, V., Farley, G., Wang, P., and Zamore, P.D. (2007). The single-stranded RNA methylase, DmHen1, modifies both Drosophila siRNAs and piRNAs and is required for silencing selfish genetic elements in the germ line. Current Biology 17, 1265-72. 

Seitz, H., Zamore, P.D. (2006).  Rethinking the Microprocessor. Cell 125, 887-901.

Sigova, A., Vagin, V., and Zamore, P.D. (2006). 'Measuring the rates of transcriptional elongation in the female Drosophila melanogaster germ line by nuclear run-on,' in Regulatory RNAs, 71st Cold Spring Harbor Symposia on Quantitative Biology 71, 335-41.  

Vagin, V.V., Sigova, A., Li, C., Seitz, H., Gvozdev, V., Zamore, P.D. (2006).  A distinct small RNA pathway silences selfish genetic elements in the germline. Science 313, 320-324.

Schwarz, D.S., Ding, H., Kennington, L., Moore, J.T. Schelter, J., Burchard, J., Linsley, P.S., Aronin, N., Xu, Z., Zamore, P.D. (2006). Designing siRNA That Distinguish between Genes That Differ by a Single Nucleotide. PLOS Genetics 2(9) e140, 1-12. 

Zamore, P.D. (2006). RNA interference: Big applause for silencing in Stockholm. Cell 127, 1083-1086. 

Tomari, Y., Zamore, P.D., (2005). MicroRNA biogenesis: drosha can’t cut it without a partner. Current Biology 15, R61-4.

Förstemann, K., Tomari, Y., Du, T., Vagin, V.V., Denli, A.M., Bratu, D.P., Klattenhoff, C., Theurkauf, W.E., and Zamore, P.D. (2005). Normal microRNA maturation by Dicer-1 and germ-line stem cell maintenance requires the double-stranded RNA-binding domain protein, Loquacious. PLoS Biology 3, e236. 

Matranga , C., and Zamore, P.D. (2005). 'Plant RNAi in vitro,'in Epigenetics, 69th Cold Spring Harbor Symposium on Quantitative Biology 69, 403-8. 

Zamore, P.D., Haley, B. (2005). Ribo-gnome: the big world of small RNAs. Science 309, 1519-24.

Du, T, Zamore, P.D., (2005). MicroPrimer: the biogenesis and function of microRNA. Development 132, 4645-52.

Matranga, C., Tomari, Y., Shin, C. Bartel, D.P., Zamore, P.D. (2005). Passenger-Strand Cleavage Facilitates Assembly of siRNA into Ago2-Containing RNAi Enzyme Complexes. Cell 123, 1-14.

Hutvágner, G., Simard, M.J., Mello, C.C., and Zamore, P.D. (2004). Sequence-specific inhibition of small RNA function. PLoS Biology 2, 465-475. 

Schwarz, D.S., Tomari, Y., and Zamore, P.D. (2004). The RNA-Induced Silencing Complex Is a Mg2+-Dependent Endonuclease. Current Biology 14, 787-791.

Zamore, P.D. (2004). Plant RNAi: How the silencing suppressor p19 inactivates siRNA. Current Biology 14, R198-R200.

Tomari, Y., Du, T., Haley, B. Schwarz, D.S., Bennett, R. Cook, H.A., Koppetsch, B.S., Theurkauf, W.E., and Zamore, P.D. (2004). RISC assembly defects in the Drosophila RNAi mutant armitage. Cell , 831-841. 

Haley, B and Zamore, P.D. (2004). Kinetic analysis of the RNAi enzyme complex. Nature Structural & Molecular Biology 11, 599-606.

Sigova, A., Rhind, N., and Zamore, P.D. (2004). A single Argonaute protein mediates both transcriptional and post-transcriptional silencing in Schizosaccharomyces pombe. Genes & Development 8, 2359-67.

Tomari, Y., Matranga, C., Haley, B., Martinez, N., and Zamore, P.D. (2004). A protein sensor for siRNA asymmetry. Science 19, 1377-80.

Tang, G., Reinhardt, B.J., Bartel, D.P., and Zamore, P.D. (2003). A Biochemical Framework for RNA Silencing in Plants. Genes & Development 17, 49-63.

Ding, H., Schwarz, D. S., Keene, A., Affar el, B., Fenton, L., Xia, X., Shi, Y., Zamore, P.D., and Xu, Z. (2003). Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis. Aging Cell 2, 209-217.

Schwarz, D.S., Hutvágner, G., Du, T., Xu, Z., Aronin, N., and Zamore, P.D. (2003). Asymmetry in the Assembly of the RNAi Enzyme. Cell 115, 199-208. 

Haley, B., Tang, Guiliang, and Zamore, P.D. (2003). In vitro analysis of RNA interference in Drosophila melanogaster. Methods 30, 330-336.

Zamore, P.D. and Aronin, N. (2003). siRNA knocks down hepatitis. Nature Medicine 9, 266-267.

Hutvágner, G. and Zamore, P.D. (2002). RNAi: Nature Abhors a Double-Strand. Current Opinion in Genetics and Development 12, 225-232. 

Zamore, P.D. (2002). Viewpoint: Ancient Pathways Programmed by Small RNAs. Science 296, 1265-1269. 

Wang, X., McLachlan, J., Zamore, P.D., and Hall, T.M.T. (2002). Modular Recognition of RNA by a Human Pumilio-Homology Domain. Cell 110, 501-512. 

Hutvágner, G. and Zamore, P.D. (2002). A MicroRNA in a Multiple-Turnover RNAi Enzyme Complex. Science 297, 2056-2060.

Schwarz, D., Hutvágner, G., Haley, B., and Zamore, P.D. (2002). Evidence that siRNAs Function as Guides, Not Primers, in the Drosophila and Human RNAi Pathways. Molecular Cell 10, 537-548.

Schwarz, D. and Zamore, P.D. (2002). Review: Why do miRNAs live in the miRNP? Genes and Development 16, 1025-31.

Zamore, P.D. (2001). RNA Interference: Listening to the Sound of Silence. Nature Structural Biology 8, 746-750. 

Nykänen, A., Haley, B., Zamore, P.D. (2001). ATP Requirements and Small Interfering RNA Structure in the RNA Interference Pathway. Cell 107, 309-321. 

Zamore, P.D. (2001). Preview. Thirty-Three Years Later, a Glimpse at the Ribonuclease III active site. Molecular Cell 8, 1158-1160. 

Hutvágner, G., McLachlan, J., Pasquinelli, A. E., Bálint, É., Tuschl, T., and Zamore, P.D. (2001). A Cellular Function for the RNA-Interference Enzyme Dicer in the Maturation of the let-7 Small Temporal RNA. Science 293, 834-838.

Wang, X., Zamore, P.D., and Hall, T.M.T. (2001). Crystal structure of a Pumilio-homology domain. Molecular Cell 7, 855-865.

Zamore, P.D. (2001). RNA interference: listening to the sound of silence. Nature Structural Biology 8, 746-750. 

Zamore, P.D., Tuschl, T., Sharp, P.A., and Bartel, D.P. (2000). RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. ell101, 25-33. 

Sharp, P.A. and Zamore, P.D. (2000). Perspective: Molecular Biology. RNA interference. Science 287, 2431-2433.