K.C. Balaji, MD

 

KC BalajiAcademic Title:  Professor and Chief, Urology
Faculty Appointment(s): Department of Surgery
Division:  Urology
Office:  55 Lake Avenue, Suite S4- 868, Worcester, MA 01655       
Phone/ Fax: (508) 856 5821/ (508) 856 3137
E-mail: kc.balaji@umassmed.edu    

Training - Clinical Interest -Research Interest -  Publications

1. Training:

Urology and Transplantation residency: University of Massachusetts Medical School, Worcester, MA
Fellowship in Urological Oncology: Memorial Sloan Kettering Cancer Center, New York, NY

2. Clinical Interests: Urological Oncology, Robotic Surgery, Laparascopic Surgery

3. Research Interests: 
Basic Science: Signal transduction in prostate cancer
Clinical: Innovation in robotic surgery

4. Publications:

ARTICLES

  1. Cheng Du, Meena Jaggi, Chuanyou Zhang and K.C. Balaji; Protein Kinase D1 (PKD1) Mediated Phosphorylation and Subcellular Localization of β-catenin: (In Press, Cancer Research,  2008)
  2. Zhong Jiang, Peigou G Chu, Bruce A Woda, Qin Liu, K.C. Balaji, Kenneth L Rock and Chin-Lee Wu; Combination of Quantitative IMP3 and Tumor Stage (QITS): A New System to Predict Metastasis for Patients with Localized Renal Cell Carcinomas:  Clin Cancer Res. 2008 Sep 1;14(17):5579-5584 
  3. Meena Jaggi, Subhash C Chauhan, Cheng Du and K.C. Balaji: Bryostatin modulates β-catenin subcellular localization and transcription activity through Protein Kinase D1 activation: Mol Cancer Ther. 2008; 7 (9): 2703-2712  (Figures on cover page)
  4. David C. Gammon, Keith A. Reed, Mausaum Patel, and K.C. Balaji: Intraurethral Fluorouracil and Lidocaine for Intraurethral Condyloma Acuminata: Am J Health-Syst Pharm, Vol 65, Oct 1, 2008
  5. Paul Mak, Meena Jaggi, Viqar Syed, Subhash Chauhan, Sazzad Hassan, Helal Biswas and K.C. Balaji: Protein Kinase D1 Influences Androgen Receptor Transcriptional Activity in Prostate Cancer: Biochem Biophys Res Commun. 373, 2008; pp. 618-623 
  6. TJ Fitzgerald, Tao Wang, Hira Lal Goel, Jiayi Huang, Gary Stein, Jane Lian, Roger J Davis, Steven Doxsey, KC Balaji, Jesse Aronowitz and Lucia R Languino: Prostate carcinoma and radiation therapy: therapeutic treatment resistance and strategies for targeted therapeutic intervention: Expert Rev. Anticancer Ther. 8(6), 967-974 (2008)
  7. Viqar Syed, Paul Mak, Cheng Du and K.C. Balaji: β-catenin Mediates Alteration in Cell Proliferation, Motility and Invasion of Prostate Cancer Cells by Differential Expression of E-Cadherin and Protein Kinase D1: J Cell Biochem. 2008 May 1;104(1):82-95 
  8. Kohl SK, Balaji KC, Smith LM, Wilson NP, Johansson SL, Sterrett SP and Abrahams NA. Clinical Significance of Benign Glands at Surgical Margins in Robotic Radical Prostatectomy Specimens. Urology. 2007 Jun; 69 (6): 1112-6
  9. Wenguang Zhang, Chuanyou Zhang, Narayini Narasa, Cheng Du and K.C. Balaji; Nuclear Translocation of Apoptosis Inducing Factor is Associated with Cisplatin Induced Apoptosis in LNCaP Prostate Cancer Cells. Cancer Letters. 2007 Sep 18;255(1):127-34.
  10. Meena Jaggi, Cheng Du, Wenguang Zhang and K.C.Balaji; Protein Kinase D1 (PKD1): A Protein of Emerging Translational Interest. (Invited review) Frontiers in Bioscience, 2007 May 1;12:3757-67
  11. Samuel Sterrett, Tanya Nazemi, Anton Galich, Gregory Peters, Lynette Smith and K.C. Balaji. Major Urological Oncological Surgeries can be Performed Using Minimally Invasive Robotic or Laparoscopic Methods with Similar Early Perioperative Outcomes Compared to Conventional Open Methods. World Journal of Urology.  2007 Apr;25(2):193-8. Epub 2006 Dec 15.
  12. Rao PS, Mallya KB, Srivenugopal KS, Balaji KC and Rao US: RNF2 interacts with the linker region of the human P-glycoprotein; Int J Oncol. 2006 Dec; 29 (6): 1413-1419
  13. Anton Galich, Samuel Sterrett, Tanya Nazemi, Garrett Pohlman, Lynette Smith and K.C. Balaji; Comparative analysis of early perioperative outcomes following radical cystectomy by either robotic or open methods; A single institution experience. Journal of Society of Laparoendoscopic Surgeons, JSLS. 2006 Apr-Jun;10(2):145-50)
  14. David J Smith, Meena Jaggi, Wenguang Zhang, Anton Galich, Cheng Du, Samuel Sterrett, Lynette Smith and K.C. Balaji; Metallothioneins and Resistance to Cisplatin and Radiation in Prostate Cancer. Urology, Vol 67, 6, 1341-47, 2006.
  15. Du C, Balaji KC. PKD1 (Protein Kinase D1). Atlas Genet Cytogenet Oncol Haematol. January 2006 .URL : http://www.infobiogen.fr/services/chromcancer/Genes/PRKCMID41860ch14q11.html
  16. Tanya Nazemi, Anton Galich, Samuel Sterrett, Douglas Klingler, Lynette Smith and K.C. Balaji; Radical Nephrectomy Performed by Open, Laparoscopy With or Without Hand-Assistance or Robotic Methods by the Same Surgeon Produces Comparable Perioperative Results. Int Braz Journal of Urology. 2006 Jan-Feb;32(1):15-22.
  17. Tanya Nazemi, Anton Galich, Lynette Smith, K.C. Balaji, Robotic Urological Surgery in Patients with Prior Abdominal Operations is Not Associated with Increased Complications. Int Journal of Urology. 2006 Mar;13(3):248-51.
  18. Meena Jaggi, Tanya Nazemi, Neil Abrahams, John Baker, Anton Galich, Lynette M Smith and K.C. Balaji. N-cadherin Switching Occurs in High Grade Prostate Cancer; Prostate. 2006 Feb 1;66(2):193-9
  19. Jaggi M, Johansson SL, Baker JJ, Smith LM, Galich A, K.C.Balaji.  Aberrant expression of E-cadherin and beta-catenin in human prostate cancer. Urological Oncology; Seminars and Original Investigations. 2005;23(6, Nov/Dec):402-406
  20. Lewis TE, Milam TD, Klingler DW, Rao PS, Jaggi M, Smith DJ, Hemstreet GP, K.C.Balaji. Tissue transglutaminase interacts with protein kinase A anchor protein 13 in prostate cancer. Urological Oncology; Seminars and Original Investigations. 2005;23(6, Nov/Dec):407-412
  21. Douglas B. Klinger, George P. Hemstreet, K.C. Balaji. Feasibility of Robotic Radical Nephrectomy – Initial Results of a Single Institution Pilot Study. Urology, 2005, 65 (6), p1086-89
  22. Tony Mammen and K.C. Balaji. Robotic Transperitoneal Detrusor Myotomy-Description of a Novel Technique. Journal of Endourology, 2005; Vol 19, Number 4, p476-479
  23. Meena Jaggi, Prema S. Rao, David J. Smith, Margaret J. Wheelock, Keith R. Johnson, George P. Hemstreet K. C. Balaji. E-cadherin Phosphorylation by PDK1/PKC mu is Associated with Altered Cellular Aggregation and Motility in Prostate Cancer; Cancer Research 2005, 65: (2), p483-492.
  24. K.C. Balaji, Somaja Louis, Prema Rao, David Smith, Simon Sherman, Lynette Hock, Dean Bacich and Denise O’Keefe: Microarray analysis of differential gene expression in androgen independent prostate cancer using a metastatic human prostate cancer cell line model. Urological Oncology; Seminars and Original Investigations. 2004 Jul-Aug; 22(4):313-20.
  25. K. C. Balaji, Paulos Yohannes, Corrigan L. McBride, Dmitry Oleynikov and George P. Hemstreet: Feasibility of robot-assisted totally intracorporeal laparoscopic ileal conduit urinary diversion: initial results of a single institutional pilot study.  Urology. Jan. 2004, Vol. 63, pp 51-55.
  26. Prema Rao, Meena Jaggi and K.C. Balaji.  Protein Kinase C Mu (PKC Mu) interacts with metallothionin2-A in prostate cancer.  Biochemical and Biophysical Research Communications, 310, 3, 1032-1038, 2003.
  27. Meena Jaggi, Prema S Rao, David J. Smith, George P Hemstreet and K.C.Balaji: Protein Kinase C Mu is Down Regulated in Androgen Independent Prostate Cancer in vitro and in vivo; Biochemical and Biophysical Research Communications, 307, 2, 254-260, 2003 
  28. K.C.Balaji, Indira Arnatovic, Andi Arnatovic and Durwood Neal, Jr. Limited additional lateral biopsies improve the diagnostic accuracy of transrectal ultrasound guided sextant prostate biopsy. Indian Journal of Urology, Vol 19, Issue 2, pages 125-128, 2003
  29. Lynette M. Hock, James Lynch and K.C. Balaji. Increasing incidence of all stages of kidney cancers over the last two decades in the United States: An analysis of the Surveillance, Epidemiology and End Results Program (SEER) data. Journal of Urology., 167 (1), 57-60, 1/2002
  30. Vladimir Kakitelashvili, Jon Thompson and K.C. Balaji: Laparoscopic vasectomy: A Case Report and Review of Literature. Journal of Endourology, Vol 16, Number 2, March, 2002.
  31. K. C. Balaji, William Fair, Ernest Feleppa, Christopher Porter, Harold Tsai, Tian Liu, Andrew Kalisz, Stella Urban, and John Gillespie: Role of advanced 2 and 3 dimensional ultrasound for detecting prostate cancer. Journal of Urology, Vol. 168, pp. 2422-2425, Dec. 2002
  32. K. C. Balaji, Bob Huryk, Steven Verhulst and William R Fair: Dietary calcium does not significantly affect heterotopic LNCaP cells tumor growth in nude mice. Prostate. Sept. 2001 ;48(4):265-73
  33. Goodarz Goodarzi, Tomoyuki Mashimo, Misako Watabe, Andrew P. Cuthbert, Robert F. Newbold, Sudha K. Pai, Shigeru Hirota, Sadahiro Hosobe, Kunio Miura, Sucharita Bandyopadhyay, Steven C. Gross, K.C. Balaji and Kounosuke Watabe. Identification of tumor metastasis suppressor region on the short arm of human chromosome 20. Genes, Chromosome and Cancer, 32 (1): 33-42, Sept. 2001
  34. E.J. Feleppa, T. Liu, A. Kalisz, D. Manolakis, W. Gnadt, F. L. Lizzi, W.R. Fair, K.C. Balaji et al., 2-D images for biopsy guidance and 3-D images for treatment planning and monitoring of prostate cancer based upon spectrum analysis and neural-network classification. Proceedings of the 1999 ultrasonics symposium. pp. 1413-1417, Institute of Electrical and Electronic engineers, Piscataway, 2000.
  35. Ernest J. Feleppa, William R. Fair, Tian Liu, Andrew Kalisz, K.C. Balaji et al., Three-Dimensional Ultrasound Analyses of the Prostate. Mol Urol, 4, 3, p133-141, 2000
  36. K.C. Balaji, Ashwinikumar Patil, Timothy Hopkins et al., Concordant Prune Belly syndrome in monozygotic twins, Urology, 55, 6, p949, 2000.
  37. Ernest J. Felleppa, William R. Fair, Tian Liu, Andrew Kalisz, William Gnadt,  Federic L Lizzi, K.C. Balaji et al., Two-dimensional and three-dimensional tissue-type imaging of the prostate based on ultrasonic spectrum analysis and neural-network classification. Ultrasonic Imaging and Signal Processing, Society of Photo-Optical Instrumentation Engineers, K.K. Shung and M. Insana (Eds), Vol 3982, pp. 152-160, Bellingham, WA, 2000
  38. Ernest J. Felleppa, William R. Fair, Tian Liu, Andrew Kalisz, William Gnadt,  Federic L Lizzi, K.C. Balaji et al., Two-dimensional and three-dimensional tissue-type imaging of the prostate based on ultrasonic spectrum analysis and neural-network classification. Prog in Biomed optics and imaging, Vol 1, 27, 152 – 60, 2000
  39. E.J. Feleppa, W.R. Fair, H. Tsai, C. Porter, K.C. Balaji et al., Progress in 2-D and 3-D ultrasonic tissue-type imaging of the prostate based on spectrum analysis and nonlinear classifiers. Mol Urol, 3, pp. 303-11, 1999
  40. K.C. Balaji, Michael McGuire, Greg Grimaldi and Paul Russo. Upper tract recurrences following radical cystectomy: Incidence, pattern and prognostic significance of recurrences: Journal of Urology., 162, 1603-6, Nov. 1999
  41. K.C. Balaji, Farhang Rabbani, Andrew Bastar and William Fair. Effect of neoadjuvant hormonal therapy on prostatic intraepithelial neoplasia and its prognostic significance: Journal of Urology., 162, 3/1, 753-7, Aug. 1999
  42. Carlos Maramag, Mani Menon, K. C. Balaji, Premveer G. Reddy and Seethalaksmi Laxmanan. Effects of vitamin C on prostate cancer cells in vitro: Effect on cell number, viability and DNA synthesis., The Prostate, 32: 188-195, 1997
  43. K. C. Balaji, Hari Koul, Sankar Mitra, Carlos Maramag, Premveer Reddy, Mani Menon, Rajwant K Malhotra and Seethalaksmi Laxmanan.  Antiproliferative effects of c-myc antisense oligonucleotide in prostate cancer cells: A novel therapy in prostate cancer: Urology, 50 (6), 1007-15,1997 
  44. K.C. Balaji and Mani Menon. Mechanism of stone formation: Urol Cli of N Amer., Vol 24,1,Feb 1997
  45. K.C. Balaji, Hari Koul, Sankar Mitra, Mani Menon and Seetha Laxmanan. Effect of c-myc antisense treatment on LNCaP prostate cancer cell line identifies a critical role of c-myc in prostate cancer. Surgical Forum, Vol XVI 896, 1996.
  46. Carlos Maramag, K. C. Balaji, Mani Menon, Seetha Laxmanan American College of Surgeons, San Francisco, Oct.1996: Effect of Vit C on prostate cancer. Surgical Forum, Vol XVI 896, 1996
  47. K.C. Balaji, Anthony Caldamone, Ronald Rabinowitz, Joseph Ortenberg and David Diamond. Splenogonadal fusion: Journal of Urology, Vol. 156, 854-856, Aug 1996.
  48. K.C. Balaji and David Diamond. Laparoscopic diagnosis and management of transverse testicular ectopia: Urology, 46, 879-880, 1995.

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BOOK CHAPTERS

  1. Narayini Narassa and K.C. Balaji; Metallothioneins and Prostate Cancer; “Metallothioneins in Biochemistry and Pathology” by Paolo Zatta: 2008, World Scientific Publishing Company, Singapore; Preorder on Amazon.com; http://www.amazon.com/METALLOTHIONEINS-BIOCHEMISTRY-PATHOLOGY-Paolo-Zatta/dp/9812778934/ref=sr_1_3?ie=UTF8&s=books&qid=1202161096&sr=1-3; (In Press, 2008)
  2. Samuel Sterrett, Tony Mammen and K.C.Balaji; Complications of Radical Prostatectomy; “Prostate Cancer – A Practical Guide”; First Edition, 2006, Elsevier, New York, NY, 2007
  3. Tony Mammen, Samuel Sterrett and K.C.Balaji; Cryotherapy for Prostate Cancer; “Prostate Cancer – A Practical Guide”; First Edition, 2006, Elsevier, New York, NY, 2007

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BOOK REVIEWS

  1. K. C. Balaji and Mani Menon., Book review: Controversies in endourology by Arthur D Smith., J of the American association of Surgeons, Vol 182, April 1996

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VIDEO ABSTRACTS 

  1. K.C. Balaji:  Robot Assisted Totally Intracorporeal Laparoscopic Ileal Conduit, SCS, AUA, 83rd annual meeting, Dublin, Ireland, Video #1, 9/04
  2. K.C. Balaji:  Robot Assisted Laparoscopic Pyeloplasty:  SCS, AUA, 83rd annual meeting, Dublin, Ireland, Video#4, 9/04
  3. K.C. Balaji:  Robotic Radical Cystoprostatectomy:  SCS, AUA, 83rd annual meeting, Dublin Ireland, Video #6, 9/04
  4. K.C. Balaji:  Robotic Radical Nephrectomy, SCS, AUA, 83rd annual meeting, Dublin, Ireland, Video #9, 9/04.
  5. K.C. Balaji:  Utilization of Hand Assistance in Excision of a Large Locally Recurrent Renal Cell Cancer, SCS, AUA, 83rd annual meeting, Dublin, Ireland, Video #ll, 9/04
  6. Tim Richardson and K.C. Balaji; Robotic Segmental Ureteral Resection and Ureteroureterostomy – Description of a Novel Technique; SCS, AUA, 84th Annual meeting, Austin, Texas, Video# 5, 9/05
  7. K.C. Balaji, Tim Richardson and Anton Galich; Utility of Laparoscopic Ureterolysis. SCS, AUA, 84th Annual meeting, Austin, Texas, Video# 6, 9/05
  8. K.C. Balaji, Tim Richardson and Anton Galich; Update on Robotic Radical Cystectomy. SCS, AUA, 84th Annual meeting, Austin, Texas, Video# 7, 9/05

 

 

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