Rehabilitation & Recovery/Ongoing Projects
Title: Neuroimaging Youth with Callous Unemotional Conduct Disorder and Co-morbid Substance Abuse
Dates: 7/1/2010 - 6/30/2015
Funder: National Institute on Drug Abuse
PI: Gina Vincent, Ph.D.
Description: Understanding the neurobiological and psychosocial factors that are associated with early drug abuse requires better knowledge of specific subtypes of adolescent drug abusers, including those who have underlying callous‐unemotional traits and serious conduct disorder (CU‐CD). Youth with CU‐CD are on a trajectory toward psychopathic personality in adulthood and drug addiction, crime, and violent behavior. They have more severe drug use and an earlier onset than other adolescent drug abusers, and therefore may have a neurobiology and reward system that is non‐selectively activated to any drugs of abuse. There may be a need for treatment and prevention strategies tailored for CU‐CD youth. This project involves a five‐year K01 career development plan to launch an independent research career that focuses on the CU‐CD population and blending neuropsychological and personality assessments with neuroimaging to better understand the early trajectory towards drug addiction and to inform treatment for this population. Research will be conducted in two settings to examine the presence of neurocognitive and affective processing abnormalities in CU‐CD youth with co‐morbid stimulant abuse/dependence, relative to non‐CU‐CD youth with stimulant abuse/dep and controls, in response to craving tasks.