Section: Research

Firoze Jungalwala, Ph.D.

Other Affiliation(s):
   Program in Neuroscience
   Shriver Center

Glyconjugates in Cellular Interactions and Neuronal Migration

Proper formation of brain in utero is extremely important, since abnormal connections and interactions of cells during this period lead to severe brain abnormalities, including mental retardation and developmental disabilities. Dr. Jungalwala and his associates are interested in defining how different areas of the brain are formed and what signals on the brain cell surfaces guide neuronal cells to their proper targets, a process necessary to form a normal functioning brain. This research also involves identifying molecules that could be responsible for regeneration after brain injury. Dr. Jungalwala has identified specific glycoconjugates that interact with their binding protein on cell surfaces. This interaction acts as a guide to neurons during their migration and arrest of migration. Biochemical, immunocytochemical, molecular biology, gene knockout, cell biology and tissue culture techniques are employed in investigating regulation and role of these molecules in the developing nervous system. This research in brain development and regeneration will provide critical information necessary for treatment of human abnormalities.

Ongoing Projects

Phone: (781) 642-0136
E-mail: Firoze.Jungalwala@umassmed.edu

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