X-ray Structures - HCV

 

 Protease variants 

Ligand 

Resolution (Å) 

R-factor (%) 

Rfree 

 PDB code

A27S/P28G/I29D/L39E/L40E/I43Q/I44E/L47Q/A66T 
   C73S/C78L/I98T/P112Q/S165A/C185S/C679S/V686I/I687N    

TIR domain-containing adapter molecule 1

 1.50

18.8 

21.5 

 3RC4

A27S/P28G/I29D/L39E/L40E/I43Q/I44E/L47Q/A66T
   C73S/C78L/I98T/P112Q/S165A/C185S/C679S/V686I/I687N   

Mitochondrial antiviral-signaling protein

 1.60

17.2 

19.3 

 3RC5

A27S/P28G/I29D/L39E/L40E/I43Q/I44E/L47Q/A66T
   C73S/C78L/I98T/P112Q/S165A/C185S/C679S/V686I/I687N   

 -

 1.30 

16.2 

19.1 

 3RC6

A27S/P28G/I29D/L39E/L40E/I43Q/I44E/L47Q/A66T
   C73S/C78L/I98T/P112Q/S165A/C185S/C679S/V686I/I687N   

ITMN-191

 1.25

15.0 

16.8 

 3M5L

A27S/P28G/I29D/L39E/L40E/I43Q/I44E/L47Q/A66T
   C73S/C78L/I98T/P112Q/S165A/C185S/C679S/V686I/I687N   

FDEMEEC Peptide

 1.70

17.8 

20.6 

 3M5M

A27S/P28G/I29D/L39E/L40E/I43Q/I44E/L47Q/A66T
   C73S/C78L/I98T/P112Q/S165A/C185S/C679S/V686I/I687N   

SECTTPC Peptide

 1.90

19.1

24.0

 3M5N

A27S/P28G/I29D/L39E/L40E/I43Q/I44E/L47Q/A66T
   C73S/C78L/I98T/P112Q/S165A/C185S/C679S/V686I/I687N   

TEDVVCC Peptide

 1.60

18.2

22.6

 3M5O