Current Lab Members

Celia_Schiffer Celia A. Schiffer, PhD - Principle Investigator

 
  /uploadedImages/SchifferLab/MohanSomasundaran.pngMohan Somasundaran, PhD - Associate Professor
Virologist

 
Akbar_Ali

Akbar Ali, PhD - Research Associate Professor

My research is devoted to the discovery and development of small molecule therapeutics against drug-resistant pathogens. Under the auspices of Prof. Celia Schiffer, I lead medicinal chemistry efforts in several research projects, involving structure-guided design, chemical synthesis, and structure-activity relationship (SAR) studies of small-molecule inhibitors targeting viral enzymes (HIV-1 protease, HCV NS3/4A protease) and host-virus interactions (Vif-APOBEC).


  
 /uploadedImages/SchifferLab/NeseKurtYilmaz.pngNese Kurt Yilmaz, PhD - Research Assistant Professor
 
  Ellen_NalivaikaEllen Nalivaika - Senior Research Associate
 
 Brendan Hilbert, PhD - Postdoctoral Associate 
  
Madhavi_Kolli Madhavi Kolli, PhD - Postdoctoral associate

I study the co-evolution of HIV-1 Protease and it’s substrates. Protease resistance mutations that alter inhibitor binding can sometimes also affect substrate binding. Drug-resistant mutations in the protease, especially those in the active site, can compromise both specificity and catalytic capability of the protease, which in turn may exert a selective pressure on the cleavage sites leading to compensatory substitutions. I have analyzed viral sequences from infected patients for mutations within the substrate cleavage sites and their correlation to resistance-associated protease mutations and for the first time observed several instances of substrate co-evolution. Structural studies of the protease-substrate complexes show changes in hydrogen bonds, van der Waal interactions and conformational changes that likely alter catalytic efficiency of the protease. In addition I am also studying how these correlated mutations affect Gag processing and thus, resistance/fitness.


  
Aysegul_Ozen

Ayşegül Özen, PhD - Postdoctoral Associate

Understanding substrate recognition, enzyme-substrate co-evolution and drug resistance in HIV-1 aspartyl and HCV NS3/4A serine proteases using x-ray crystallography, molecular modeling, and dynamics simulations.

Incoporating the dynamic substrate envelope into the design of new drugs targeting ensembles of drug-resistant proteases.

 
 
 Janet Paulsen, PhD - Postdoctoral Associate 
  
  Shivender Shandilya, PhD - Postdoctoral associate

 
Markus-Fredrick_Bohn Markus-Frederik Bohn, M.Sc. - Visiting PhD student, Nuremberg, Germany

APOBEC3A is an extremely potent DNA mutator that has been shown to involve in degradation of foreign DNA in phagocytic cells and cancer development. AID and/or APOBEC3F/A may also play a significant role in epigenetic reprogramming. Our focus lies on establishing APOBEC3 proteins as host-encoded molecular targets for antiviral strategies by using a structural and biochemical approach.  http://www.bananamark.com


  
  Brendan Hilbert, PhD - Postdoctoral Associate
 
Kuan-Hung_Lin Kuan-Hung Lin - PhD student

 
 Kristina_PrachanronarongKristina Prachanronarong - MD/PhD student
 Debra Ann Ragland - PhD student
  
 Tania Silvas - PhD student 
 
Djade_Soumana Djade Soumana - PhD student

I earned my BS in Biochemistry and Molecular Biology from the University of Massachusetts at Amherst. Currently, I'm a PhD candidate in the Biochemistry and Pharmacology Department here at UMass, where I'm studying the atomic basis for drug resistance in Hepatitis C. With a combinatorial use of structural biology and enzyme kinetics, I'm interested in investigating how of mutations in the HCV NS3 protease confers drug resistance.


 
  Candice Dufour - Administrative Assistant

Latest News

Gordon Research Conference: Drug Resistance

Stonehill College, Easton, MA

July 29 - August 3, 2012

Click for info