INTERNATIONAL MDM2 WORKSHOP IV
SCHEDULE
Sunday, September 30th
2:00 - 6:00 PM Registration at Swope Center, MBL
6:00 - 7:30 PM Dinner / Swope Dining Hall
SESSION 1: Welcome and Keynote Addresses (chair S. Jones)
Lillie Auditorium
7:30 - 7:40 PM Opening remarks and comments on Workshop agenda
Stephen Jones
7:40 - 7:50 PM Welcome, introduction and history of the MBL
Gary Borisy, Director of the MBL
7:50 - 8:35 PM Mdm2 – not only a negative regulator of p53? (1)
Moshe Oren - Keynote Address
8:35 - 9:15 PM Functions and regulation of Mdmx, an essential regulator of p53 activity. (2)
Aart Jochemsen - Keynote Address
9:30 - 11:00 PM Reception at the SWOPE Center
Monday, October 1st
7:30 - 8:30 AM Breakfast / Swope Dining Hall
SESSION 2: Regulation of Mdm2 and p53 (chair C. Eischen)
Lillie Auditorium
8:30 - 9:00 AM The role of MDM-2 and p53 polymorphisms in cancer and fecundity. (3)
Arnold Levine
9:00 - 9:30 AM New observations on the Mdm2 /p53 circuit. (4)
Carol Prives
9:30 - 9:50 AM Reciprocal regulation between Polo-like kinase 1 (Plk1) and the p53 pathway involves Plk1-mediated phosphorylation and activation of Mdm2 and p53-mediated repression of Plk1. (5)
David Meek
9:50 - 10:10 AM Regulated nuclear import of p53 by direct binding to Importin alpha 3 might contribute to stress-mediated nuclear accumulation. (6)
Natasha Marchenko
10:10 - 10:30 AM In vivo functions of E4F1-mediated regulation of the p53 family. (7)
Laurent Le Cam
10:30 - 10:50 AM ------Coffee Break / Group Photo-------
10:50 - 11:20 AM The Wip1 phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop. (8)
Larry Donehower
11:20 - 11:50 AM The role of p53 modifications in modulating its tumor suppressor function. (9)
Wei Gu
11:50 - 12:10 PM MDM2 phosphorylation by ATM is critical for rapid p53 stabilization after DNA damage.(50)
Jiandong Chen
12:10 - 12:25 PM Regulation of the Mdm2-p53 pathway through NEDDylation of ribosomal proteins. (11)
Dimitris Xirodimas- AACR Young Investigator Award
12:30 - 2:00 PM Lunch / Swope Dining Hall
SESSION 3: MDM2/MDMX and Other Cell Regulators of p53 (chair S. Grossman)
Sponsored by Johnson & Johnson Pharmaceutical Services, LLC
Lillie Auditorium
2:00 - 2:30 PM Post-translational modifications of Mdm2 and their implication for p53 degradation. (13)
Christine Blattner
2:30 - 2:50 PM Proteasomal degradation of p53 and p73. (14)
Yosef Shaul
2:50 - 3:10 PM p53-independent remodeling of ARF complexes from ARF- PARF to ARF-MDM2 in response to DNA damage. (15)
Dawn Quelle
3:10 - 3:30 PM Differential roles of p300 and CBP in p53 regulation. (16)
Steven Grossman
3:30 - 3:45 PM Sooty Foot Ataxia, a new mouse mutant that is haplo- insufficient for a large subunit ribosomal protein resulting in widespread activation of the p53 tumor suppressor throughout mouse development. (17)
Neil Box - AACR Young Investigator Award
3:45 - 4:15 PM ------Coffee Break-------
4:15 - 4:45 PM Regulation of the MDM2-MDMX-p53-p21 pathway. (18)
Hua Lu
4:45 - 5:05 PM MDM2, p53 and Rb networking in controlling cell proliferation, cell death, and cell differentiation. (19)
Jim Xiao
5:05 - 5:25 PM HdmX transcripts are reduced following genotoxic stress. (20)
Steven Berberich
5:25 - 5:45 PM HEY1-mediated repression of MDMX links NOTCH to p53 in tumor suppression. (21)
Heinrich Kovar
5:45 - 6:05 PM Regulation of p53 by c-Abl through phosphorylation of Hdmx. (22)
Ygal Haupt
6:05 - 6:25 PM New insights into the physiological function of the constitutive photomorphogenic protein 1, COP1. (23)
Jean Christophe Marine- EMBO Young Investigator Lecture
6:30 – 8:00 PM Dinner / Swope Dining Hall
8:00 - 10:00 PM POSTER SESSION I (Swope Center /refreshments)
Tuesday, October 2nd
7:30 - 8:30 AM Breakfast / Swope Dining Hall
SESSION 4: Physiological Functions of MDM Proteins (chair J. Xiao)
Lillie Auditorium
8:30 - 9:00 AM The Mdm2/Mdm4 complex: a rheostat for p53 activity. (24)
Guillermina Lozano
9:00 - 9:30 AM The impact of Mdm2 and Mdmx subcellular distribution and abundance on p53 pathway responses. (25)
Geoffrey Wahl
9:30 - 9:50 AM Targeted inactivation of Mdm2 RING E3 ligase in the mouse reveals new insights into p53 regulation. (26)
Yanping Zhang
9:50 - 10:10 AM p53-dependent and p53-independent functions of Mdm2 contribute to tumor development. (27)
Christine Eischen
10:10 - 10:30 AM MdmX promotes bipolar mitosis to suppress transformation and tumorigenesis in p53-deficient cells and mice. (28)
Stephen Jones
10:30 - 10:50 AM ------Coffee Break-------
10:50 - 11:10 AM Human oncoprotein MDM2 enhances Akt phosphorylation reducing the sensitivity of cancer cells to chemotherapeutic drugs. (29)
Swati Deb
11:10 - 11:30 AM Coordinately spliced MDM2 and MDM4 implicate a cancer spliceome in pediatric rhabdomyosarcomas. (30)
Dawn Chandler
11:30 - 11:45 AM Association of HDM2-transcript variant expression and SNP309 with age of onset and prognosis in human tumors. (31)
Frank Bartel - AACR Young Investigator Award
11:45 - 12:00 PM Dissecting Mdm2 and Mdmx oncogenic properties in vivo using conditional transgenic mice. (32)
Agnieszka Gembarska - AACR Young Investigator Award
12:00 -12:15 PM Identifying novel and conserved genes in the p53 regulatory loop in zebrafish. (33)
John Parant - AACR Young Investigator Award
12:30 - 1:30 PM Lunch / Swope Dining Hall
1:30 - 3:15 PM POSTER SESSION II (Swope Center /refreshments)
Social Event / Workshop Banquet
3:15 - 3:30 PM Meet at Woods Hole Ferry Dock to board the Ferry
3:45 - 4:30 PM Ferry Trip to Martha's Vineyard (Vineyard Haven)
4:30 - 5:00 PM Meet Buses - tour "down island"
5:15 - 6:15 PM Visit Edgartown
6:15 - 6:45 PM Reload buses / trip to Sailing Camp
6:45 - 9:00 PM New England–style clambake
9:00 - 9:30 PM Bus trip back to Vineyard Haven Ferry
9:30 - 10:15 PM Ferry back to Woods Hole
Wednesday, October 3rd
7:30 - 8:30 AM Breakfast / Swope Dining Hall / Dorm check-out
SESSION 5: p53 Regulators as Therapeutic Targets in Cancer (chair X. Lu)
Sponsored by Hoffmann-La Roche Inc.
Lillie Auditorium
8:30 - 9:00 AM Regulation of p53 stability and activity by ubiquitination. (34)
Karen Vousden
9:00 - 9:30 AM Intervention in p53 regulation by inhibitors of the p53-MDM2 interaction. (35)
Lyubomir Vassilev
9:30 - 10:00 AM p53 regulators as therapeutic targets in cancer. (36)
Xin Lu
10:00 - 10:15 AM Targeting the human double minute (HDM)-2 p53 ubiquitin ligase as a strategy against non-Hodgkin lymphoma. (37)
Richard Jones - AACR Young Investigator Award
10:15- 10:30 AM Modulation of p53-dependent apoptosis by Hdmx. (38)
Mark Wade - AACR Young Investigator Award
10:30- 10:50 AM --Coffee Break / Pre-ordered Box Lunches available at Swope--
10:50 - 11:10 AM Nutlin-3, but not DNA damage, disrupts a p53-Mdm2 complex to allow for transcriptional activation and G1 arrest in SNP309 cancer cells. (39)
Jill Bargonetti
11:10 - 11:30 AM Nutlin3 blocks VEGF induction by preventing the interaction between HIF1α and Hdm2. (40)
Lindsey Mayo
11:30 - 11:45 AM HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 Function. (41)
Loretta Lau - AACR Young Investigator Award
11:45 - 12:00 PM Workshop Summary
Carol Prives
12:00 - 1:00 PM Lunch / Swope Dining Hall / Depart