Representative publications (updated November 2012)

For updated publications, please see our Profiles page.

Mishra, B.B., Rathinam, V. A. K., Martens, G. W., Martinot, A. J., Kornfeld, H., Fitzgerald, K. A., Sassetti, C. M. Nitric oxide controls tuberculosis immunopathology by inhibiting NLRP3 inflammasome-dependent IL-1b processing. Nat. Immunol. In Press. (2012).

Cyclic-AMP regulation of protein lysine acetylation in Mycobacterium tuberculosis. Li, H.J., Fortune, S.F., Sassetti, C.M. Alber, T. Nat. Struc. Mol. Biol. 19: 811–818 (2012).

Zhang, Y.J., Ioerger, T.R., Huttenhower, C., Long, J.E., Sassetti, C.M., Sacchettini, J.C. and Rubin, E.J. Global Assessment of Genomic Regions Required for Growth in Mycobacterium tuberculosis. Plos Pathog. PLoS Pathog 8(9): e1002946. doi:10.1371/journal.ppat.1002946.

Role in metal homeostasis of CtpD, a Co(2+) transporting P(1B4) -ATPase of Mycobacterium smegmatis. Raimunda D, Long JE, Sassetti CM, Argüello JM. Mol Microbiol. 84(6):1139-49 (2012)

Griffin, J.E.,, Pandey, A.K., Gilmore, S.A., Mizrahi, V., Mckinney, J.D., Bertozzi, C.B., and Sassetti, C.M. Cholesterol catabolism by Mycobacterium tuberculosis requires transcriptional and metabolic adaptations. In Press. Chemistry and Biology (2012).

Gee, C.L., Papavinasasundaram, K.G., Blair, S..R., Baer, C., Falick, A.M., King, D.S., Griffin. J., Venghatakrishnan, H., Christopher M. Sassetti* and Tom Alber*. A pseudokinase complex controls cell wall synthesis in mycobacteria. *Corresponding authors. In Press. Science Signalling. (2012).

Griffin, J.E., Gawronski, J.D., DeJesus, M.A., Ioerger, T. R., Akerley, B. A., Sassetti, C.M. High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. PLoS Pathogens. 7(9): e1002251 (2011)

Baek, S., Li, A.H., Sassetti, C.M. Metabolic regulation mycobacterial growth and antibiotic sensitivity. PLoS Biol 9(5): e1001065. doi:10.1371/journal.pbio.1001065 (2011).

Lee J, Repasy T, Papavinasasundaram K, Sassetti C, Kornfeld H. Mycobacterium tuberculosis induces an atypical cell death mode to escape from infected macrophages. PLoS One. Mar 31;6(3):e18367. (2011)

Wei, J.R., Krishnamoorthy, V., Murphy, K.C., Kim, J., Schnappinger, D., Alber, D.A., Sassetti, C.M., Rhee, K.Y. and Rubin, E.J. Antibiotic targets vary in their sensitivity to inhibition by depletion. PNAS 108 (10) 4176-4181. (2011)

Fong SS, Rearden P, Kanchagar C, Sassetti C, Trevejo J, Brereton RG. Automated Peak Detection and Matching Algorithm for Gas Chromatography-Differential Mobility Spectrometry. Anal Chem. (2011)

Ioerger, T. R., Feng, Y., Ganesula, K., Chen, X., Dobos, K. M., Fortune, S., Jacobs, W. R., Jr., Mizrahi, V., Parish, T., Rubin, E., Sassetti, C.M., Sacchettini, J. C. Variation Among Genome Sequences of H37Rv Strains of M. tuberculosis from Multiple Laboratories. J. Bacteriology. (2010)

Chang, J.C., Miner, M.D., Pandey, A.K., Gill, W.P., Harik, N.S., Sassetti, C.M., and Sherman, D.R. igr Genes and M. tuberculosis Cholesterol Metabolism. J. Bacteriology. 191:5232-5239. (2009)

Coulombe, F., Divangahi, M., Veyrier, F., de Léséleuc, L., Gleason, J.L., Yang, Y., Kelliher, M.A., Pandey, A.K., Sassetti, C.M., Reed, M., Behr, M.A.. Increased NOD2-Mediated Recognition of N-Glycolyl Muramyl Dipeptide. J. Exp. Med. 206:1709-1716. (2009)

Murry, J. M., Pandey, A.K., Sassetti, C.M., Rubin, E. J. Phthiocerol dimycocerosate transport is required for resisting IFN gamma-independent immunity. Journal of Infectious Diseases. 200:774-782 (2009)

Pandey, A., Yang, Y., Jiang, Z., Fortune, S., Coulombe, F., Behr, M.A., Fitzgerald, K.A., Sassetti, C.M.*, Kelliher, M.A*. NOD2, RIP2 and IRF5 Play a Critical Role in the Type I Interferon Response to Mycobacterium tuberculosis. PLoS Pathogens. 5(7): e1000500. doi:10.1371/journal.ppat.1000500 (2009). *corresponding authors.

Pandey, A. K, Raman, S, Proff, R, Joshi, S, Kang, C., Rubin, E., Husson, R., and Sassetti, C.M. Nitrile-inducible gene expression in mycobacteria. Tuberculosis 89:12-16 (2009).

Pandey, A.K. and Sassetti, C.M. Mycobacterial persistence requires the utilization of host cholesterol. Proc. Nat. Acad. Sci. 105 (11):4376-4380. (2008)

Yang, Y., Yin, C., Pandey, A.K., Abbott,D., Sassetti, C.M., Kelliher, M.A. NOD2 pathway activation by MDP or Mycobacterium tuberculosis infection involves the stable polyubiquitination of Rip2. J. Biol. Chem. 282:36223-9. (2007)

Joshi, S. M., Pandey, A.K., Capite, N., Fortune, S.M., Rubin, E.J., and Sassetti, C.M. Characterization of mycobacterial virulence genes through genetic interaction mapping. Proc. Nat. Acad. Sci. 103:11760-11765. (2006)

Murry, J., Sassetti, C.M., Moreira, J., Lane, J., and Rubin, E.J.. A new site-specific integration system for mycobacteria. Tuberculosis. 85(5-6):317-23, (2005).

Fortune S.M, Jaeger A., Chase M.R, Sarracino, D.A, Sassetti C.M, Sherman D.R., Bloom B.R. and Rubin E.J. Mutually-dependent secretion of proteins required for mycobacterial virulence. Proc. Nat. Acad. Sci. 102:10676-81. (2005).

Rengarajan,J., Sassetti, C. M., Naroditskaya, V., Sloutsky, A., Bloom, B.R. and Rubin, E. J.. The folate pathway is a target for resistance to the drug para-aminosalicylic acid (PAS) in mycobacteria. Molecular Microbiology 53:275-282 (2004)

Sassetti, C. M. and Rubin, E. J. Genetic requirements for mycobacterial survival during infection. Proc. Nat. Acad. Sci. 100:12989-12994 (2003)

Sassetti, C. M., Boyd, D. H. and Rubin, E. J. Genes required for mycobacterial growth defined by high density mutagenesis. Molecular Microbiology. 48: 77-84. (2003)

Sassetti, C. M., Boyd, D. H. and Rubin, E. J. Comprehensive identification of conditionally essential genes in mycobacteria. Proc. Nat. Acad. Sci. 98: 12712-12717. (2001)