Dormancy and Antibiotic Action

M. tuberculosis responds to the stress of host immunity by slowing its growth and metabolic rate. This response renders the bacterium tolerant to both immune effectors and antibiotic treatment. Using a combination of genetic and metabolomic approaches, we seek to understand the physiological state of these quiescent cells and design new strategies to improve antibiotic efficacy.
(For more information see this commentary on our work.)

 

Dormancy_Picture2

Alterations in metabolite pools
upon exposure to growth-limiting stress