Research in the Gottlinger laboratory focuses on interactions between HIV-1, the virus that causes AIDS, and the host cell in which it propagates. One major goal is to understand the role of a cellular membrane fission machinery in the assembly and release of infectious HIV-1 particles from the cell surface. Another area of interest are cellular factors that are potentially involved in the organization of the viral RNA genome and its uptake into HIV-1 particles. Furthermore, the Gottlinger laboratory investigates the function of an accessory HIV-1 protein called Nef, which is not essential for the virus to multiply, but for unknown reasons is crucial for its ability to cause disease.
For more information, please visit Dr. Heinrich Gottlinger Faculty Profile.