Page Menu

Publications of Interest

Demo G, Svidritskiy E, Madireddy R, Diaz-Avalos R, Grant T, Grigorieff N, Sousa D, Korostelev AA. Mechanism of ribosome rescue by ArfA and RF2. Elife. 2017 Mar 16;6. pii: e23687. doi: 10.7554/eLife.23687. PMID: 28300532.

Gammon DB, Ishidate T, Li L, Gu W, Silverman N, Mello CC. Curr Biol. 2017 Mar 20;27(6):795-806. doi: 10.1016/j.cub.2017.02.004. Epub 2017 Mar 2. PMID: 28262484 The Antiviral RNA Interference Response Provides Resistance to Lethal Arbovirus Infection and Vertical Transmission in Caenorhabditis elegans.

Song C-Q, Li Y, Mou H, Moore J, Park A, Pomyen Y, Hough S, Kennedy Z, Fischer A, Yin H, Anderson DG, Conte Jr D, Zender L, Wang XW, Thorgeirsson S, Weng Z, Xue W Genome-wide CRISPR Screen Identifies Regulators of MAPK as Suppressors of Liver Tumors in Mice. Gastroenterology(2017), doi: 10.1053/j.gastro.2016.12.002

Ly S, Navaroli DM, Didiot MC, Cardia J, Pandarinathan L, Alterman JF, Fogarty K, Standley C, Lifshitz LM, Bellve KD, Prot M, Echeverria D, Corvera S, Khvorova A. Visualization of self-delivering hydrophobically modified siRNA cellular internalization. Nucleic Acids Res. 2016 Nov 28. pii: gkw1005. [Epub ahead of print] PMID: 27899655

Haraszti RA, Didiot MC, Sapp E, Leszyk J, Shaffer SA, Rockwell HE, Gao F, Narain NR, DiFiglia M, Kiebish MA, Aronin N, Khvorova A. High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources. J Extracell Vesicles. 2016 Nov 17;5:32570. doi: 10.3402/jev.v5.32570. eCollection 2016. PMID:27863537

Keeler AM, Sapp E, Chase K, Sottosanti E, Danielson E, Pfister E, Stoica L, DiFiglia M, Aronin N, Sena-Esteves M. Cellular Analysis of Silencing the Huntington's Disease Gene Using AAV9 Mediated Delivery of Artificial Micro RNA into the Striatum of Q140/Q140 Mice. J Huntingtons Dis. 2016 Oct 1;5(3):239-248. PMID: 27689620

Ma H, Tu LC, Naseri A, Huisman M, Zhang S, Grunwald D, Pederson T. CRISPR-Cas9 nuclear dynamics and target recognition in living cells. J Cell Biol. 2016 Aug 29;214(5):529-37. doi: 10.1083/jcb.201604115. PMID: 27551060

Didiot MC, Hall LM, Coles AH, Haraszti RA, Godinho BM, Chase K, Sapp E, Ly S, Alterman JF, Hassler MR, Echeverria D, Raj L, Morrissey DV, DiFiglia M, Aronin N, Khvorova A. Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing. Mol Ther. 2016 Oct;24(10):1836-1847. doi: 10.1038/mt.2016.126. PMID: 27506293

Ge DT, Tipping C, Brodsky MH, Zamore PD. Rapid Screening for CRISPR-Directed Editing of the Drosophila Genome Using white Coconversion. G3 (Bethesda). 2016 Oct 13;6(10):3197-3206. doi: 10.1534/g3.116.032557. PMID: 27543296

Pendergraff HM, Debacker AJ, Watts JK. Single-Stranded Silencing RNAs: Hit Rate and Chemical Modification. Nucleic Acid Ther. 2016 Aug;26(4):216-22. doi: 10.1089/nat.2015.0557. PMID: 27123752

Nikan M, Osborn MF, Coles AH, Godinho BM, Hall LM, Haraszti RA, Hassler MR, Echeverria D, Aronin N, Khvorova A. Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain. Mol Ther Nucleic Acids. 2016 Aug 9;5(8):e344. doi: 10.1038/mtna. 2016.50. PMID:27504598

Loveland AB, Bah E, Madireddy R, Zhang Y, Brilot AF, Grigorieff N, Korostelev AA. Ribosome•RelA structures reveal the mechanism of stringent response activation. Elife. 2016 Jul 19;5. pii: e17029. doi: 10.7554/eLife.17029. PMID: 27434674

Vodicka P, Chase K, Iuliano M, Valentine DT, Sapp E, Lu B, Kegel-Gleason KB, Sena-Esteves M, Aronin N, DiFiglia M. Effects of Exogenous NUB1 Expression in the Striatum of HDQ175/Q7 Mice. J Huntingtons Dis. 2016 Jun 13;5(2):163-74. doi: 10.3233/JHD-160195. PMID: 27314618

Hoskins AA, Rodgers ML, Friedman LJ, Gelles J, Moore MJ. Single molecule analysis reveals reversible and irreversible steps during spliceosome activation. Elife. 2016 May 31;5. pii: e14166. doi: 10.7554/eLife.14166. PMID: 27244240

Svidritskiy E, Madireddy R, Korostelev AA. Structural Basis for Translation Termination on a Pseudouridylated Stop Codon. J Mol Biol. 2016 May 22;428(10 Pt B):2228-36. doi: 10.1016/j.jmb.2016.04.018. PMID: 27107638

Abeyrathne PD, Koh CS, Grant T, Grigorieff N, Korostelev AA. Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome. Elife. 2016 May 9;5. pii: e14874. doi: 10.7554/eLife.14874. PMID: 27159452

Ma H, Tu LC, Naseri A, Huisman M, Zhang S, Grunwald D, Pederson T. Multiplexed labeling of genomic loci with dCas9 and engineered sgRNAs using CRISPRainbow. Nat Biotechnol. 2016 May;34(5):528-30. doi: 10.1038/nbt.3526. Epub 2016 Apr 18. PMID: 27088723

Coles AH, Osborn MF, Alterman JF, Turanov AA, Godinho BM, Kennington L, Chase K, Aronin N, Khvorova A. A High-Throughput Method for Direct Detection of Therapeutic Oligonucleotide-Induced Gene Silencing In Vivo. Nucleic Acid Ther. 2016 Apr;26(2):86-92. doi: 10.1089/nat.2015.0578. Epub 2015 Nov 23. PMID: 26595721

Liu W, Pfister EL, Kennington LA, Chase KO, Mueller C, DiFiglia M, Aronin N. Does the Mutant CAG Expansion in Huntingtin mRNA Interfere with Exonucleolytic Cleavage of its First Exon? J Huntingtons Dis. 2016 Mar 19;5(1):33-8. doi: 10.3233/JHD-150183. PMID: 27003665

Tang W, Tu S, Lee HC, Weng Z, Mello CC. The RNase PARN-1 Trims piRNA 3' Ends to Promote Transcriptome Surveillance in C. elegans. Cell. 2016 Feb 25;164(5):974-84. doi: 10.1016/j.cell.2016.02.008. PMID: 26919432

Akama-Garren EH, Joshi NS, Tammela T, Chang GP, Wagner BL, Lee DY, Rideout Iii WM, Papagiannakopoulos T, Xue W, Jacks T. A Modular Assembly Platform for Rapid Generation of DNA Constructs. Sci Rep. 2016 Feb 18;6:16836. doi: 10.1038/srep16836. PMID: 26887506

Heyer EE, Moore MJ. Redefining the Translational Status of 80S Monosomes. Cell. 2016 Feb 11;164(4):757-69. doi: 10.1016/j.cell.2016.01.003. PMID: 26871635

Yin, H, Song, C-Q, Dorkin, JR, Zhu, LJ, Li, Y, Wu, Q, Park, A, Yang, J, Suresh, S, Bizhanova, A, Gupta, A, Bolukbasi, MF, Walsh, S, Bogorad, RL, Gao, G, Weng, Z, Dong, Y, Koteliansky, V, Wolfe, SA, Langer, R, Xue, W, Anderson, DG. Therapeutic Genome Editing By Combined Viral and Non-viral Delivery of Crispr System Components in Vivo. Nat Biotechnol. 2016 Mar;34(3):328-33. doi: 10.1038/nbt.3471. Epub 2016 Feb 1. PMID: 26829318

Sharma U, Conine CC, Shea JM, Boskovic A, Derr AG, Bing XY, Belleannee C, Kucukural A, Serra RW, Sun F, Song L, Carone BR, Ricci EP, Li XZ, Fauquier L, Moore MJ, Sullivan R, Mello CC, Garber M, Rando OJ. Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals. Science. 2016 Jan 22;351(6271):391-6. doi: 10.1126/science.aad6780. Epub 2015 Dec 31.PMID: 26721685

Smith C, Lari A, Derrer CP, Ouwehand A, Rossouw A, Huisman M, Dange T, Hopman M, Joseph A, Zenklusen D, Weis K, Grunwald D, Montpetit B. In vivo single-particle imaging of nuclear mRNA export in budding yeast demonstrates an essential role for Mex67p. J Cell Biol. 2015 Dec 21;211(6):1121-30. doi: 10.1083/jcb.201503135. PMID: 26694837

Alterman JF, Hall LM, Coles AH, Hassler MR, Didiot MC, Chase K, Abraham J, Sottosanti E, Johnson E, Sapp E, Osborn MF, Difiglia M, Aronin N, Khvorova A. Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain. Mol Ther Nucleic Acids. 2015 Dec 1;4:e266. doi: 10.1038/mtna.2015.38.PMID: 26623938

Smith CS, Stallinga S, Lidke KA, Rieger B, Grunwald Probability-based particle detection that enables threshold-free and robust in vivo single-molecule tracking. D. Mol Biol Cell. 2015 Nov 5;26(22):4057-62. doi: 10.1091/mbc.E15-06-0448. Epub 2015 Sep 30. PMID: 26424801

Svidritskiy E, Korostelev AA. Ribosome Structure Reveals Preservation of Active Sites in the Presence of a P-Site Wobble Mismatch. Structure. 2015 Nov 3;23(11):2155-61. doi: 10.1016/j.str.2015.08.011. Epub 2015 Sep 24.PMID: 26412335

Johnson E, Chase K, McGowan S, Mondo E, Pfister E, Mick E, Friedline RH, Kim JK, Sapp E, DiFiglia M, Aronin N Safety of Striatal Infusion of siRNA in a Transgenic Huntington's Disease Mouse Model. . J Huntingtons Dis. 2015;4(3):219-29. doi: 10.3233/JHD-150163.PMID: 26444021

Zhang Y, Rajan R, Seifert HS, Mondragón A, Sontheimer EJ. DNase H Activity of Neisseria meningitidis Cas9. Mol Cell. 2015 Oct 15;60(2):242-55. doi:10.1016/j.molcel.2015.09.020. PMID: 26474066

Osborn MF, Alterman JF, Nikan M, Cao H, Didiot MC, Hassler MR, Coles AH, Khvorova A. Guanabenz (Wytensin™) selectively enhances uptake and efficacy of hydrophobically modified siRNAs. Nucleic Acids Res. 2015 Oct 15;43(18):8664-72. doi: 10.1093/nar/gkv942. Epub 2015 Sep 22. PMID: 26400165

Gu W, Gallagher GR, Dai W, Liu P, Li R, Trombly MI, Gammon DB, Mello CC, Wang JP, Finberg RW. Influenza A virus preferentially snatches noncoding RNA caps. RNA. 2015 Oct 1. [Epub ahead of print] PMID: 26428694

Chou MT, Han BW, Hsiao CP, Zamore PD, Weng Z, Hung JH. Tailor: a computational framework for detecting non-templated tailing of small silencing RNAs. Nucleic Acids Res. 2015 Sep 30;43(17):e109. doi: 10.1093/nar/gkv537. Epub 2015 May 24. PMID: 26007652

Wakefield N, Rajan R, Sontheimer EJ. Primary processing of CRISPR RNA by the endonuclease Cas6 in Staphylococcus epidermidis. FEBS Lett. 2015 Sep 10. pii: S0014-5793(15)00822-4. doi: 10.1016/j.febslet.2015.09.005. [Epub ahead of print] PMID: 26364721

Vashisht AA, Wohlschlegel JA, Ambros VR. Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal. Zinovyeva AY, Veksler-Lublinsky I, Proc Natl Acad Sci U S A. 2015 Sep 8. pii: 201506576. [Epub ahead of print] PMID: 26351692

Wang W, Han BW, Tipping C, Ge DT, Zhang Z, Weng Z, Zamore PD. Slicing and Binding by Ago3 or Aub Trigger Piwi-Bound piRNA Production by Distinct Mechanism Mol Cell. 2015 Sep 3;59(5):819-30. doi: 10.1016/j.molcel.2015.08.007. PMID: 26340424

Wang D, Mou H, Li S, Li Y, Hough S, Tran K, Li J, Yin H, Anderson DG, Sontheimer EJ, Weng Z, Gao G, Xue W. Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses. Hum Gene Ther. 2015 Jul;26(7):432-42. doi: 10.1089/hum.2015.087. PMID: 26086867

Elewa A, Shirayama M, Kaymak E, Harrison PF, Powell DR, Du Z, Chute CD, Woolf H, Yi D, Ishidate T, Srinivasan J, Bao Z, Beilharz TH, Ryder SP, Mello CC. POS-1 Promotes Endo-mesoderm Development by Inhibiting the Cytoplasmic Polyadenylation of neg-1 mRNA. Dev Cell. 2015 Jul 6;34(1):108-18. doi: 10.1016/j.devcel.2015.05.024. Epub 2015 Jun 18. PMID: 26096734

Salomon WE, Jolly SM, Moore MJ, Zamore PD, Serebrov V. Single-Molecule Imaging Reveals that Argonaute Reshapes the Binding Properties of Its Nucleic Acid Guides. Cell. 2015 Jul 2;162(1):84-95. doi: 10.1016/j.cell.2015.06.029. PMID: 26140592

Li Y, Park A, Mou H, Colpan C, Bizhanova A, Akama-Garren E, Joshi N, Hendrickson EA, Feldser D, Yin H, Anderson DG, Jacks T, Weng Z, Xue W. A versatile reporter system for CRISPR-mediated chromosomal rearrangements. Genome Biol. 2015 May 28;16(1):111. [Epub ahead of print] PMID: 26018130

Smith CS, Preibisch S, Joseph A, Abrahamsson S, Rieger B, Myers E, Singer RH, Grunwald D. Nuclear accessibility of β-actin mRNA is measured by 3D single-molecule real-time tracking. J Cell Biol. 2015 May 25;209(4):609-19. doi: 10.1083/jcb.201411032. PMID: 26008747

Han BW, Wang W, Li C, Weng Z, Zamore PD. Noncoding RNA. piRNA-guided transposon cleavage initiates Zucchini-dependent, phased piRNA production. Science. 2015 May 15;348(6236):817-21. doi: 10.1126/science.aaa1264. PMID: 25977554

Ren Z, Ambros VR. Caenorhabditis elegans microRNAs of the let-7 family act in innate immune response circuits and confer robust developmental timing against pathogen stress. Proc Natl Acad Sci U S A. 2015 May 5;112(18):E2366-75. doi:10.1073/pnas.1422858112. Epub 2015 Apr 20. PMID: 25897023

Roy CK, Olson S, Graveley BR, Zamore PD, Moore MJ. Assessing long-distance RNA sequence connectivity via RNA-templated DNA-DNA ligation. Elife. 2015 Apr 13;4. doi: 10.7554/eLife.03700. [Epub ahead of print] PMID: 25866926

Tsai HY, Chen CC, Conte D Jr, Moresco JJ, Chaves DA, Mitani S, Yates JR 3rd, Tsai MD, Mello CC. A ribonuclease coordinates siRNA amplification and mRNA cleavage during RNAi. Cell. 2015 Jan 29;160(3):407-19. doi: 10.1016/j.cell.2015.01.010. PMID: 25635455

Harandi OF, Ambros VR. Control of stem cell self-renewal and differentiation by the heterochronic genes and the cellular asymmetry machinery in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):E287-96. doi: 10.1073/pnas.1422852112. PMID: 25561544

Wang W, Yoshikawa M, Han BW, Izumi N, Tomari Y, Weng Z, Zamore PD. The Initial Uridine of Primary piRNAs Does Not Create the Tenth Adenine that Is the Hallmark of Secondary piRNAs. Mol Cell. 2014 Dec 4;56(5):708-16. doi: 10.1016/j.molcel.2014.10.016. Epub 2014 Nov 20. PMID: 25453759 [PubMed - in process]

Sánchez-Rivera FJ, Papagiannakopoulos T, Romero R, Tammela T, Bauer MR, Bhutkar A, Joshi NS, Subbaraj L, Bronson RT, Xue W, Jacks T. Rapid modelling of cooperating genetic events in cancer through somatic genome editing. Nature. 2014 Dec 18;516(7531):428-31. doi: 10.1038/nature13906. Epub 2014 Oct 22. PMID: 25337879

Heyer EE, Ozadam H, Ricci EP, Cenik C, and Moore MJ. An Optimized Kit-free Method for Making Strand-specific Deep Sequencing Libraries From RNA Fragments. Nucleic Acids Res. published 12 December 2014, 10.1093/nar/gku1235

Han, BW, Wang, W, Zamore, PD, and Weng, Z. piPipes: a set of pipelines for piRNA and transposon analysis via small RNA-seq, RNA-seq, degradome- and CAGE-seq, ChIP-seq and genomic DNA sequencing. Bioinformatics. published 17 October 2014, 10.1093/bioinformatics/btu647

Xue W, Chen S, Yin H, Tammela T, Papagiannakopoulos T, Joshi NS, Cai W, Yang G, Bronson R, Crowley DG, Zhang F, Anderson DG, Sharp PA, Jacks T. CRISPR-mediated direct mutation of cancer genes in the mouse liver. Nature. 2014 Oct 16;514(7522):380-4. doi: 10.1038/nature13589. Epub 2014 Aug 6. PMID:25119044

Xue W, Dahlman JE, Tammela T, Khan OF, Sood S, Dave A, Cai W, Chirino LM, Yang GR, Bronson R, Crowley DG, Sahay G, Schroeder A, Langer R, Anderson DG, Jacks T. Small RNA Combination Therapy for Lung Cancer. Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):E3553-61. doi: 10.1073/pnas.1412686111. Epub 2014 Aug 11

Ward J, Kanchagar C, Veksler-Lublinsky I, Lee RC, McGill MR, Jaeschke H, Curry SC, Ambros VR. Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis. Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12169-74. doi: 10.1073/pnas.1412608111. Epub 2014 Aug 4.

Hurtado S, Kim Guisbert KS, Sontheimer EJ. SPO24 is a transcriptionally dynamic, small ORF-encoding locus required for efficient sporulation in Saccharomyces cerevisiae. PLoS One. 2014 Aug 15;9(8):e105058. doi: 10.1371/journal.pone.0105058. eCollection 2014. PMID: 25127041

Svidritskiy E, Brilot AF, Koh CS, Grigorieff N, Korostelev AA. Structures of yeast 80S ribosome-tRNA complexes in the rotated and nonrotated conformations. Structure. 2014 Aug 5;22(8):1210-8. doi: 10.1016/j.str.2014.06.003. Epub 2014 Jul 17. PMID: 25043550 [PubMed - in process]

Sterling, C. H., Veksler-Lublinksy, I., & Ambros, V. (2014). An efficient and sensitive method for preparing cDNA libraries from scarce biological samples. Nucleic Acids Research. doi:10.1093/nar/gku637

Gammon DB, Duraffour S, Rozelle DK, Hehnly H, Sharma R, Sparks ME, West CC, Chen Y, Moresco JJ, Andrei G, Connor JC, Conte D, Gundersen-Rindal DE, Marshall WL, Yates J, Silverman N, Mello CC. A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection. Elife. 2014 Jun 25:e02910. doi: 10.7554/eLife.02910. [Epub ahead of print]

Carpenter S, Ricci EP, Mercier BC, Moore MJ, Fitzgerald KA. Post-transcriptional regulation of gene expression in innate immunity. Nat Rev Immunol. 2014 Jun;14(6):361-76. doi: 10.1038/nri3682. Review. PMID:24854588 [PubMed - indexed for MEDLINE]

Koh CS, Brilot AF, Grigorieff N, Korostelev AA. Taura syndrome virus IRES initiates translation by binding its tRNA-mRNA-like structural element in the ribosomal decoding center. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9139-44. doi: 10.1073/pnas.1406335111. Epub 2014 Jun 9. PMID: 24927574 [PubMed - indexed for MEDLINE]

Broderick JA, Zamore PD. Competitive endogenous RNAs cannot alter microRNA function in vivo. Mol Cell. 2014 Jun 5;54(5):711-3. doi: 10.1016/j.molcel.2014.05.023. PMID: 24905003

Zhang Z, Wang J, Schultz N, Zhang F, Parhad SS, Tu S, Vreven T, Zamore PD, Weng Z, Theurkauf WE. The HP1 homolog rhino anchors a nuclear complex that suppresses piRNA precursor splicing. Cell. 2014 Jun 5;157(6):1353-63. doi: 10.1016/j.cell.2014.04.030. PMID:24906152

Kim H, Ishidate T, Ghanta KS, Seth M, Conte D Jr, Shirayama M, Mello CC. A Co-CRISPR Strategy for Efficient Genome Editing in Caenorhabditis elegans. Genetics. 2014 May 30. pii: genetics.114.166389. [Epub ahead of print]

Ishidate T, Elewa A, Kim S, Mello CC, Shirayama M. Divide and differentiate: CDK/Cyclins and the art of development. Cell Cycle. 2014 May 1;13(9):1384-91. doi: 10.4161/cc.28656. Epub 2014 Mar 26. Review. PMID: 24675894 [PubMed - in process]

Fukunaga R, Zamore PD. A universal small molecule, inorganic phosphate, restricts the substrate specificity of Dicer-2 in small RNA biogenesis. Cell Cycle. 2014 Jun 1;13(11):1671-6. doi: 10.4161/cc.29066. Epub 2014 Apr 30. PMID:24787225

Zinovyeva AY, Bouasker S, Simard MJ, Hammell CM, Ambros V. Mutations in conserved residues of the C. elegans microRNA Argonaute ALG-1 identify separable functions in ALG-1 miRISC loading and target repression. PLoS Genet. 2014 Apr 24;10(4):e1004286. doi: 10.1371/journal.pgen.1004286. eCollection 2014 Apr. PMID: 24763381 [PubMed - indexed for MEDLINE]

Moran Y, Fredman D, Praher D, Li XZ, Wee LM, Rentzsch F, Zamore PD, Technau U, Seitz H. Cnidarian microRNAs frequently regulate targets by cleavage. Genome Res. 2014 Apr;24(4):651-63. doi: 10.1101/gr.162503.113. Epub 2014 Mar 18. PMID:24642861

Shirayama M, Stanney W 3rd, Gu W, Seth M, Mello CC. The Vasa Homolog RDE-12 Engages Target mRNA and Multiple Argonaute Proteins to Promote RNAi in C. elegans. Curr Biol. 2014 Mar 26. pii: S0960-9822(14)00267-X. doi: 10.1016/j.cub.2014.03.008. [Epub ahead of print]

Zhang Z, Koppetsch BS, Wang J, Tipping C, Weng Z, Theurkauf WE, Zamore PD. Antisense piRNA amplification, but not piRNA production or nuage assembly, requires the Tudor-domain protein Qin. EMBO J. 2014 Mar 18;33(6):536-9. doi: 10.1002/embj.201384895. No abstract available. PMID:24652836

Yang C, Wang H, Qiao T, Yang B, Aliaga L, Qiu L, Tan W, Salameh J, McKenna-Yasek DM, Smith T, Peng L, Moore MJ, Brown RH Jr, Cai H, Xu Z. Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2014 Mar 10. [Epub ahead of print]

Chen W, Moore MJ. The spliceosome: disorder and dynamics defined. Curr Opin Struct Biol. 2014 Feb 11;24C:141-149. doi: 10.1016/j.sbi.2014.01.009.

Träger U, Andre R, Lahiri N, Magnusson-Lind A, Weiss A, Grueninger S, McKinnon C, Sirinathsinghji E, Kahlon S, Pfister EL, Moser R, Hummerich H, Antoniou M, Bates GP, Luthi-Carter R, Lowdell MW, Björkqvist M, Ostroff GR, Aronin N, Tabrizi SJ. HTT-lowering reverses Huntington's disease immune dysfunction caused by NFκB pathway dysregulation. Brain. 2014 Mar;137(Pt 3):819-33. doi: 10.1093/brain/awt355. Epub 2014 Jan 22.

Evans MS, Chaurette JP, Adams ST Jr, Reddy GR, Paley MA, Aronin N, Prescher JA, Miller SC. A synthetic luciferin improves bioluminescence imaging in live mice. Nat Methods. 2014 Apr;11(4):393-5. doi: 10.1038/nmeth.2839. Epub 2014 Feb 9. Erratum in: Nat Methods. 2014 Apr;11(4):395. PMID:24509630 [PubMed - indexed for MEDLINE]

Fukunaga R, Colpan C, Han BW, Zamore PD. Inorganic phosphate blocks binding of pre-miRNA to Dicer-2 via its PAZ domain.  EMBO J. Published 31 January 2014, 10.1002/embj.201387176

Chen W, Shulha HP, Ashar-Patel A, Yan J, Green KM, Query CC, Rhind N, Weng Z, Moore MJ. Endogenous U2·U5·U6 snRNA complexes in S. pombe are intron lariat spliceosomes. RNA. 2014; Published in Advance January 17, 2014, doi:10.1261/rna.040980.113

Kearns NA, Genga RM, Enuameh MS, Garber M, Wolfe SA, Maehr R.Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells. Development. 2014 Jan;141(1):219-223.

Seth M, Shirayama M, Gu W, Ishidate T, Conte D Jr, Mello CC. The C. elegans CSR-1 argonaute pathway counteracts epigenetic silencing to promote germline gene expression. Dev Cell. 2013 Dec 23;27(6):656-63.

Conine CC, Moresco JJ, Gu W, Shirayama M, Conte D Jr, Yates JR 3rd, Mello CC. Argonautes promote male fertility and provide a paternal memory of germline gene expression in C. elegans. Cell. 2013 Dec 19;155(7):1532-44. doi: 10.1016/j.cell.2013.11.032.

Ricci EP, Kucukural A, Cenik C, Mercier BC, Singh G, Heyer EE, Ashar-Patel A, Peng L, Moore MJ. Staufen1 senses overall transcript secondary structure to regulate translation. Nat Struct Mol Biol. 2014 Jan;21(1):26-35. doi: 10.1038/nsmb.2739. Epub 2013 Dec 15. PMID: 24336223 [PubMed - indexed for MEDLINE]

Brilot AF, Korostelev AA, Ermolenko DN, Grigorieff N. Structure of the ribosome with elongation factor G trapped in the pretranslocation state. PNAS 2013 ; published ahead of print December 9, 2013, doi:10.1073/pnas.1311423110

Byrne M, Tzekov R, Wang Y, Rodgers A, Cardia J, Ford G, Holton K, Pandarinathan L, Lapierre J, Stanney W, Bulock K, Shaw S, Libertine L, Fettes K, Khvorova A, Kaushal S, Pavco P. Novel hydrophobically modified asymmetric RNAi compounds (sd-rxRNA) demonstrate robust efficacy in the eye. J Ocul Pharmacol Ther. 2013 Dec;29(10):855-64. doi: 10.1089/jop.2013.0148. Epub 2013 Nov 1. PMID: 24180627 [PubMed - indexed for MEDLINE]

Zhang Z, Almeida S, Lu Y, Nishimura AL, Peng L, Sun D, Wu B, Karydas AM, Tartaglia MC, Fong JC, Miller BL, Farese RV Jr, Moore MJ, Shaw CE, Gao FB. Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations. PLoS One. 2013 Oct 15;8(10):e76055. doi: 10.1371/journal.pone.0076055. eCollection 2013. PMID:24143176 [PubMed - indexed for MEDLINE]

Singh G, Ricci EP, Moore MJ. RIPiT-Seq: a high-throughput approach for footprinting RNA:protein complexes. Methods. 2014 Feb;65(3):320-32. doi: 10.1016/j.ymeth.2013.09.013. Epub 2013 Oct 2. PMID:24096052 [PubMed - indexed for MEDLINE]

Shcherbakova I, Hoskins AA, Friedman LJ, Serebrov V, Corrêa IR Jr, Xu MQ, Gelles J, Moore MJ. Alternative spliceosome assembly pathways revealed by single-molecule fluorescence microscopy. Cell Rep. 2013 Oct 17;5(1):151-65. doi: 10.1016/j.celrep.2013.08.026. Epub 2013 Sep 26.

Kucukural A, Ozadam H, Singh G, Moore MJ, Cenik C. ASPeak: an abundance sensitive peak detection algorithm for RIP-Seq. Bioinformatics. 2013 Aug 12. [Epub ahead of print] PubMed PMID: 23929032.

Han BW, Zamore PD. piRNAs. Curr Biol. 2014 Aug 18;24(16):R730-3. doi: 10.1016/j.cub.2014.07.037. PMID: 25137579

Carpenter S, Aiello D, Atianand MK, Ricci EP, Gandhi P, Hall LL, Byron M, Monks B, Henry-Bezy M, Lawrence JB, O'Neill LA, Moore MJ, Caffrey DR, Fitzgerald KA. A long noncoding RNA mediates both activation and repression of immune response genes. Science. 2013 Aug 16;341(6147):789-92. doi: 10.1126/science.1240925. Epub 2013 Aug 1. PubMed PMID: 23907535.

Ameres SL, Zamore PD. Diversifying microRNA sequence and function. Nat Rev Mol Cell Biol. 2013 Aug;14(8):475-88. doi: 10.1038/nrm3611. Epub 2013 Jun 26. Review. PMID:23800994

Svidritskiy E, Ling C, Ermolenko DN, Korostelev AA. Blasticidin S inhibits translation by trapping deformed tRNA on the ribosome. Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12283-8. doi: 10.1073/pnas.1304922110. Epub 2013 Jul 3. PubMed PMID: 23824292; PubMed Central PMCID: PMC3725078.

Santos N, Zhu J, Donohue JP, Korostelev AA, Noller HF. Crystal structure of the 70S ribosome bound with the Q253P mutant form of release factor RF2. Structure. 2013 Jul 2;21(7):1258-63. doi: 10.1016/j.str.2013.04.028. Epub 2013 Jun 13. PubMed PMID: 23769667.

Babcock GJ, Iyer S, Smith HL, Wang Y, Rowley K, Ambrosino DM, Zamore PD, Pierce BG, Molrine DC, Weng Z. High-throughput sequencing analysis of post-liver transplantation HCV E2 glycoprotein evolution in the presence and absence of neutralizing monoclonal antibody. PLoS One. 2014 Jun 23;9(6):e100325. doi: 10.1371/journal.pone.0100325. eCollection 2014. PMID: 24956119

Li XZ, Roy CK, Moore MJ, Zamore PD. Defining piRNA primary transcripts. Cell Cycle. 2013 Jun 1;12(11):1657-8. doi: 10.4161/cc.24989. Epub 2013 May 10. PubMed PMID: 23673320.

Nieuwenhuizen RP, Lidke KA, Bates M, Puig DL, Grünwald D, Stallinga S, Rieger B. Measuring image resolution in optical nanoscopy. Nat Methods. 2013 Jun;10(6):557-62. doi: 10.1038/nmeth.2448. Epub 2013 Apr 28. PubMed PMID: 23624665.

Jokhi V, Ashley J, Nunnari J, Noma A, Ito N, Wakabayashi-Ito N, Moore MJ, Budnik V. Torsin mediates primary envelopment of large ribonucleoprotein granules at the nuclear envelope. Cell Rep. 2013 Apr 25;3(4):988-95. doi: 10.1016/j.celrep.2013.03.015. Epub 2013 Apr 11. PubMed PMID: 23583177; PubMed Central PMCID: PMC3683601.

Bossé GD, Rüegger S, Ow MC, Vasquez-Rifo A, Rondeau EL, Ambros VR, Grosshans H, Simard MJ. The decapping scavenger enzyme DCS-1 controls microRNA levels in Caenorhabditis elegans. Mol Cell. 2013 Apr 25;50(2):281-7. doi: 10.1016/j.molcel.2013.02.023. Epub 2013 Mar 28. PubMed PMID: 23541767.

Crawford DJ, Hoskins AA, Friedman LJ, Gelles J, Moore MJ. Single-molecule colocalization FRET evidence that spliceosome activation precedes stable approach of 5' splice site and branch site. Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6783-8. doi: 10.1073/pnas.1219305110. Epub 2013 Apr 8. PubMed PMID: 23569281; PubMed Central PMCID: PMC3637735.

Ge DT, Zamore PD. Small RNA-directed silencing: the fly finds its inner fission yeast? Curr Biol. 2013 Apr 22;23(8):R318-20. doi: 10.1016/j.cub.2013.03.033. PubMed PMID: 23618667.

Li XZ, Roy CK, Dong X, Bolcun-Filas E, Wang J, Han BW, Xu J, Moore MJ, Schimenti JC, Weng Z, Zamore PD. An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes. Mol Cell. 2013 Apr 11;50(1):67-81. doi: 10.1016/j.molcel.2013.02.016. Epub 2013 Mar 21. PubMed PMID: 23523368; PubMed Central PMCID: PMC3671569.

Kim S, Ishidate T, Sharma R, Soto MC, Conte D Jr, Mello CC, Shirayama M. Wnt and CDK-1 regulate cortical release of WRM-1/β-catenin to control cell division orientation in early Caenorhabditis elegans embryos. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):E918-27. doi: 10.1073/pnas.1300769110. Epub 2013 Feb 19. PubMed PMID: 23431196; PubMed Central PMCID: PMC3593879.

Liu W, Chaurette J, Pfister EL, Kennington LA, Chase KO, Bullock J, Vonsattel JP, Faull RL, Macdonald D, DiFiglia M, Zamore PD, Aronin N. Increased Steady-State Mutant Huntingtin mRNA in Huntington's Disease Brain. J Huntingtons Dis. 2013;2(4):491-500. doi: 10.3233/JHD-130079. PMID:25062733

Flores-Jasso CF, Salomon WE, Zamore PD. Rapid and specific purification of Argonaute-small RNA complexes from crude cell lysates. RNA. 2013 Feb;19(2):271-9. doi: 10.1261/rna.036921.112. Epub 2012 Dec 18. PubMed PMID: 23249751; PubMed Central PMCID: PMC3543083.

van der Bom IM, Moser RP, Gao G, Sena-Esteves M, Aronin N, Gounis MJ. Frameless multimodal image guidance of localized convection-enhanced delivery of therapeutics in the brain. J Neurointerv Surg. 2013 Jan 1;5(1):69-72. doi: 10.1136/neurintsurg-2011-010170. Epub 2011 Dec 22. PubMed PMID: 22193239; PubMed Central PMCID: PMC3533401.

Zhang Z, Theurkauf WE, Weng Z, Zamore PD. Strand-specific libraries for high throughput RNA sequencing (RNA-Seq) prepared without poly(A) selection. Silence. 2012 Dec 28;3(1):9. doi: 10.1186/1758-907X-3-9. PubMed PMID: 23273270; PubMed Central PMCID: PMC3552703.

D'Ambrogio A, Gu W, Udagawa T, Mello CC, Richter JD. Specific miRNA stabilization by Gld2-catalyzed monoadenylation. Cell Rep. 2012 Dec 27;2(6):1537-45. doi: 10.1016/j.celrep.2012.10.023. Epub 2012 Nov 29. PubMed PMID: 23200856; PubMed Central PMCID: PMC3534910.

Gu W, Lee HC, Chaves D, Youngman EM, Pazour GJ, Conte D Jr, Mello CC. CapSeq and CIP-TAP identify Pol II start sites and reveal capped small RNAs as C. elegans piRNA precursors. Cell. 2012 Dec 21;151(7):1488-500. doi: 10.1016/j.cell.2012.11.023. PubMed PMID: 23260138; PubMed Central PMCID: PMC3581324.

Singer S, Zhao R, Barsotti AM, Ouwehand A, Fazollahi M, Coutavas E, Breuhahn K, Neumann O, Longerich T, Pusterla T, Powers MA, Giles KM, Leedman PJ, Hess J, Grunwald D, Bussemaker HJ, Singer RH, Schirmacher P, Prives C. Nuclear pore component Nup98 is a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes. Mol Cell. 2012 Dec 14;48(5):799-810. doi: 10.1016/j.molcel.2012.09.020. Epub 2012 Oct 24. PubMed PMID: 23102701; PubMed Central PMCID: PMC3525737.

Bicknell AA, Cenik C, Chua HN, Roth FP, Moore MJ. Introns in UTRs: why we should stop ignoring them.Bioessays. 2012 Dec;34(12):1025-34. doi: 10.1002/bies.201200073. Epub 2012 Oct 26. PubMed PMID: 23108796.

Wee LM, Flores-Jasso CF, Salomon WE, Zamore PD. Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties. Cell. 2012 Nov 21;151(5):1055-67. doi: 10.1016/j.cell.2012.10.036. Erratum in: Cell. 2013 Jan 17;152(1-2):366. PubMed PMID: 23178124; PubMed Central PMCID: PMC3595543.

Singh G, Kucukural A, Cenik C, Leszyk JD, Shaffer SA, Weng Z, Moore MJ. The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus. Cell. 2012 Nov 9;151(4):750-64. doi: 10.1016/j.cell.2012.10.007. Epub 2012 Oct 18. Erratum in: Cell. 2012 Nov 9;151(4):915-6. PubMed PMID: 23084401; PubMed Central PMCID: PMC3522173.

Aronin N, Moore M. Hunting down huntingtin. N Engl J Med. 2012 Nov;367(18):1753-4. doi: 10.1056/NEJMcibr1209595. PubMed PMID: 23113488.

Fukunaga R, Han BW, Hung JH, Xu J, Weng Z, Zamore PD. Dicer partner proteins tune the length of mature miRNAs in flies and mammals. Cell. 2012 Oct 26;151(3):533-46. doi: 10.1016/j.cell.2012.09.027. Epub 2012 Oct 11. Erratum in: Cell. 2012 Nov 9;151(4):912. PubMed PMID: 23063653; PubMed Central PMCID: PMC3609031.

Wu CH, Fallini C, Ticozzi N, Keagle PJ, Sapp PC, Piotrowska K, Lowe P, Koppers M, McKenna-Yasek D, Baron DM, Kost JE, Gonzalez-Perez P, Fox AD, Adams J, Taroni F, Tiloca C, Leclerc AL, Chafe SC, Mangroo D, Moore MJ, Zitzewitz JA, Xu ZS, van den Berg LH, Glass JD, Siciliano G, Cirulli ET, Goldstein DB, Salachas F, Meininger V, Rossoll W, Ratti A, Gellera C, Bosco DA, Bassell GJ, Silani V, Drory VE, Brown RH Jr, Landers JE. Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis. Nature. 2012 Aug 23;488(7412):499-503. doi: 10.1038/nature11280. PubMed PMID: 22801503; PubMed Central PMCID: PMC3575525.

Li L, Gu W, Liang C, Liu Q, Mello CC, Liu Y. The translin-TRAX complex (C3PO) is a ribonuclease in tRNA processing. Nat Struct Mol Biol. 2012 Aug;19(8):824-30. doi: 10.1038/nsmb.2337. Epub 2012 Jul 8. PubMed PMID: 22773104; PubMed Central PMCID: PMC3414638.

Shirayama M, Seth M, Lee HC, Gu W, Ishidate T, Conte D Jr, Mello CC. piRNAs initiate an epigenetic memory of nonself RNA in the C. elegans germline. Cell. 2012 Jul 6;150(1):65-77. doi: 10.1016/j.cell.2012.06.015. Epub 2012 Jun 25. PubMed PMID: 22738726; PubMed Central PMCID: PMC3597741.  

Lee HC, Gu W, Shirayama M, Youngman E, Conte D Jr, Mello CC. C. elegans piRNAs mediate the genome-wide surveillance of germline transcripts. Cell. 2012 Jul 6;150(1):78-87. doi: 10.1016/j.cell.2012.06.016. Epub 2012 Jun 25. PubMed PMID: 22738724; PubMed Central PMCID: PMC3410639.  

Zamore PD. RNA: methods and protocols - a new series. Silence. 2012 Jun 7;3(1):7. doi: 10.1186/1758-907X-3-7. PubMed PMID: 22676652; PubMed Central PMCID: PMC3420260.  

Speese SD, Ashley J, Jokhi V, Nunnari J, Barria R, Li Y, Ataman B, Koon A, Chang YT, Li Q, Moore MJ, Budnik V.Nuclear envelope budding enables large ribonucleoprotein particle export during synaptic Wnt signaling. Cell. 2012 May 11;149(4):832-46. doi: 10.1016/j.cell.2012.03.032. Erratum in: Cell. 2012 Oct 26;151(3):687-9. PubMed PMID: 22579286; PubMed Central PMCID: PMC3371233.

Hoskins AA, Moore MJ. The spliceosome: a flexible, reversible macromolecular machine. Trends Biochem Sci. 2012 May;37(5):179-88. doi: 10.1016/j.tibs.2012.02.009. Epub 2012 Apr 3. Review. PubMed PMID: 22480731; PubMed Central PMCID: PMC3508674.

Sapp E, Valencia A, Li X, Aronin N, Kegel KB, Vonsattel JP, Young AB, Wexler N, DiFiglia M. Native mutant huntingtin in human brain: evidence for prevalence of full-length monomer. J Biol Chem. 2012 Apr 13;287(16):13487-99. doi: 10.1074/jbc.M111.286609. Epub 2012 Feb 27. PubMed PMID: 22375012; PubMed Central PMCID: PMC3339996.

Xie J, Ameres SL, Friedline R, Hung JH, Zhang Y, Xie Q, Zhong L, Su Q, He R, Li M, Li H, Mu X, Zhang H, Broderick JA, Kim JK, Weng Z, Flotte TR, Zamore PD, Gao G. Long-term, efficient inhibition of microRNA function in mice using rAAV vectors. Nat Methods. 2012 Mar 4;9(4):403-9. doi: 10.1038/nmeth.1903. PubMed PMID: 22388288; PubMed Central PMCID: PMC3420816.

Grünwald D, Singer RH. Multiscale dynamics in nucleocytoplasmic transport. Curr Opin Cell Biol. 2012 Feb;24(1):100-6. doi: 10.1016/j.ceb.2011.11.011. Epub 2011 Dec 22. Review. PubMed PMID: 22196930; PubMed Central PMCID: PMC3294057.

Khvorova A, Wolfson A. New competition in RNA regulation. Nat Biotechnol. 2012 Jan 9;30(1):58-9. doi: 10.1038/nbt.2092. PubMed PMID: 22231098.