RNA Therapeutics Institute Faculty

RTI Bullet Neil Aronin, M.D.


Professor, Department of Medicine


Focus:
Pathogenesis of neurodegenerative diseases, especially Parkinson's disease and Huntington's disease.

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David Grunwald

RTI Bullet David Grunwald, Ph.D.


Assistant Professor


Focus:
The interface between microscopy development and (nuclear) cell biology, with a strong focus on the travels of mRNA and nucleocytoplasmic transport.

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RTI Bullet Anastasia Khvorova, Ph.D.


Professor


Focus:
Development of novel oligonucleotide-based therapeutics, drug development. Mechanism of small RNA trafficing, RNA medicinal chemistry and delivery.

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RTI Bullet Andrei Korostelev, Ph.D.


Associate Professor


Focus:
Structure and function of ribosome.

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RTI BulletCraig Mello, Ph.D.


Investigator Howard Hughes Medical Institute, Blais Chair of Molecular Medicine, Professor


Focus:
Investigation of the mechanism of RNA interference; investigation of how embryonic cells differentiate and communicate during development.

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RTI BulletMelissa J. Moore, Ph.D.


Investigator Howard Hughes Medical Institute, Eleanor Eustis Farrington Chair in Cancer Research, Professor


Focus:
Post-transcriptional gene regulation in eukaryotes via mechanisms involving RNA.

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RTI BulletErik Sontheimer, Ph.D.


Professor


Focus:
Biology and mechanism of RNA-based gene regulation; CRISPR interference; RNA-directed genome editing and gene control.

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Jon Watts

RTI BulletJonathan K. Watts, Ph.D.


Associate Professor

Focus:
Chemistry and chemical biology of oligonucleotides; Nucleic acid drug development.

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Wen Xue

RTI BulletWen Xue, Ph.D.


Assistant Professor


Focus:
Mouse models of cancer. Use CRISPR genome editing to functionally dissect cancer mutations in liver and lung cancer.

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RTI BulletPhillip Zamore, Ph.D.


Investigator Howard Hughes Medical Institute, Gretchen Stone Cook Professor of Biomedical Sciences, Chair and Professor


Focus:
Dissecting the RNAi and miRNA pathways

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RTI Research Faculty


 Darryl Conte, PH.D.

RTI BulletDarryl Conte, Ph.D.


Research Assistant Professor


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RTI Affiliated Faculty


Raffi Aroian

RTI BulletRaffi V. Aroian, Ph.D.


Professor, Program in Molecular Medicine


Focus:
Intestinal parasitic nematodes, drug discovery, autoimmune diseases, host-pathogen interactions. Bacillus thuringiensis. Cellular responses to pore-forming toxins.

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RTI BulletRobert Brown, M.D.


Professor and Chair, Department of Neurology


Focus:
Neuromuscular diseases including amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease), muscular dystrophy, adrenoleukodystrophy, hereditary neuropathy and hyperkalemic periodic paralysis.

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Vivian Budnik

RTI BulletVivian Budnik, Ph.D.


Professor, Neurobiology


Focus:
Molecular Mechanisms of Synapse Assembly and Plasticity

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RTI BulletMichael P. Czech, Ph.D.


Professor and Chair, Program in Molecular Medicine


Focus:
RNAi-based therapeutic strategies for inflammatory and metabolic diseases.

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RTI BulletTerence Flotte, M.D.


Dean School of Medicine, Provost and Executive Deputy Chancellor, Professor, Pediatrics


Focus:
Recombinant adeno-associated virus (AAV) gene therapy vectors for, cystic fibrosis (CF), alpha-1-antitrypsin deficiency (AAT) and fatty oxidation disorders (FAO)

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RTI BulletJane E. Freedman, M.D.


Director, Translational Research, UMass Memorial Heart & Vascular Center, Professor, Department of Medicine


Focus:
Immunity, inflamation and circulation transcripts in atherothrombotic disease in a basic and high-throughput laboratory.

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RTI BulletFen-Biao Gao, Ph.D.


Professor, Neurology


Focus:
Understanding frontotemporal dementia and neuronal microRNAs.

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RTI BulletGuangping Gao, Ph.D.


Professor Department of Microbiology and Physiological Systems, Director Gene Therapy Center & Vector Core, Scientific Director UMMS-China Translational Research Initiatives


Focus:
Adeno-associated virus (AAV) vector mediated gene transfer for gene therapy & gene therapy of inherited neurodegenerative Canavan Disease.

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Manuel Garber

RTI BulletManuel Garber, Ph.D.


Associate Professor Program in Molecular Medicine, Director of the UMMS Bioinformatics core


Focus:
Molecular evolution, mechanisms of transcriptional regulation of innate immune responses, functional characterization of the non-coding genome

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RTI BulletMichael Green, Ph.D., M.D.


Professor and Director, Program in Gene Function and Expression, Professor Program in Molecular Medicine


Focus:
Eukaryotic gene regulation and cancer molecular biology.

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RTI BulletDale L. Greiner Ph.D.


Professor Program in Molecular Medicine


Focus:
To understand the etiology and pathogenesis of autoimmune type 1 diabetes mellitus (T1D).

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RTI BulletGang Han, Ph.D.


Assistant Professor, Biochemistry and Molecular Pharmacology


Focus:
Synthetic nanomaterials for siRNA delivery and biomolecule imaging.

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 David Harlan

RTI BulletDavid M. Harlan M.D.


Professor,  Department of Medicine; Chief, Diabetes; Co-Director, Diabetes Center of Excellence


Focus:
Focus:  Tolerance mechanisms and organ/tissue transplantation.  Autoimmune illnesses, especially insulin dependent diabetes mellitus. Human beta cell biology. Improving diabetes care delivery systems.

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RTI BulletAllan Jacobson, Ph.D.


Professor and Chair, Department of Microbiology and Physiological Systems


Focus:
Cytoplasmic Aspects of the Post-transcriptional Regulation of Gene Expression.

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RTI BulletNathan Lawson, Ph.D.


Associate Professor, Program in Molecular Medicine


Focus:
Role of non-coding RNA's in vascular development and disease.

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RTI BulletJeremy Luban, M.D.


David L. Freelander Memorial Professor in HIV/AIDS Research, Professor in Molecular Medicine


Focus:
HIV-1 replication, pathogenesis, and immunity.

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Rene Maehr

RTI BulletRene Maehr, Ph.D.


Assistant Professor, Program in Molecular Medicine


Focus:
Pluripotent stem cell-based models of immune deficiencies and autoimmunity.

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RTI BulletGary Ostroff, Ph.D.


Research Professor, Program in Molecular Medicine


Focus:
Nanomaterial science to develop delivery technology targeting chronic diseases.

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RTI BulletJoel Richter, Ph.D.


Professor, Program in Molecular Medicine


Focus:
Translational Control of Meiosos, Mitosos, and Neuronal Synaptic Platicity.

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RTI BulletSean Ryder, Ph.D.


Associate Professor, Biochemistry and Molecular Pharmacology


Focus:
RNA-binding proteins in development and disease.

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RTI BulletWilliam Theurkauf, Ph.D.


Professor, Program in Molecular Medicine


Focus:
Eukaryotic gene regulation and cancer molecular biology.

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RTI BulletZuoshang Xu, M.D., Ph.D.


Professor, Biochemistry and Molecular Pharmacology


Focus:
Mechanism and Therapy of Neurodegenerative Diseases.

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