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Current Stem Cell News

Coronary arteries hold heart-regenerating cells
Endothelial cells residing in the coronary arteries can function as cardiac stem cells to produce new heart muscle tissue, investigators have discovered. The heart has long been considered to be an organ without regenerative potential, said one expert. Recent findings, however, have demonstrated that new heart muscle cells are generated at a low rate, suggesting the presence of cardiac stem cells. The source of these cells was unknown.
Zebrafish help unravel Alzheimer's disease
New fundamental knowledge about the regulation of stem cells in the nerve tissue of zebrafish embryos results in surprising insights into neurodegenerative disease processes in the human brain. A new study identifies the molecules responsible for this process.
Tissue development 'roadmap' created to guide stem cell medicine
In a boon to stem cell research and regenerative medicine, scientists have created a computer algorithm called CellNet as a 'roadmap' for cell and tissue engineering, to ensure that cells engineered in the lab have the same favorable properties as cells in our own bodies.
New blood: Tracing the beginnings of hematopoietic stem cells
Researchers elaborate upon a crucial signaling pathway and the role of key proteins, which may help clear the way to generate HSCs from human pluripotent precursors, similar to advances with other kinds of tissue stem cells.
Cell discovery brings blood disorder cure closer
A cure for a range of blood disorders and immune diseases is in sight, according to scientists who have unraveled the mystery of stem cell generation. Found in the bone marrow and in umbilical cord blood, HSCs are critically important because they can replenish the body's supply of blood cells. Leukemia patients have been successfully treated using HSC transplants, but medical experts believe blood stem cells have the potential to be used more widely.
Clinical trial evaluates safety of stem cell transplantation in spine
A clinical trial to investigate the safety of neural stem cell transplantation in patients with chronic spinal cord injuries has been launched in the United States. Related goals of the clinical trial include evaluating the stem cell graft's survival and the effectiveness of immunosuppression drugs to prevent rejection. The researchers will also look for possible therapeutic benefits such as changes in motor and sensory function, bowel and bladder function, and pain levels.
Not only in DNA's hands: Epigenetics has large say in blood formation
Every day trillions of blood cells are being formed in our body: from the oxygen-carrying red blood cells to the many types of white blood cells that fight pathogens and infection. All of these highly specialized cells originate from blood stem cells -- unique cells that have the potential to mature into all blood types. How exactly is the fate of these stem cells regulated? Preliminary findings are starting to reshape the conventional understanding of the way stem cell fate decisions are controlled, thanks to a new technique for epigenetic analysis they have developed.
How breast cancer usurps powers of mammary stem cells
During pregnancy, certain hormones trigger specialized mammary stem cells to create milk-producing cells essential to lactation. Scientists have found that mammary stem cells associated with the pregnant mammary gland are related to stem cells found in breast cancer. "By understanding a fundamental mechanism of mammary gland development during pregnancy, we have gained a rare insight into how aggressive breast cancer might be treated," said the lead author.
Breakthroughs made in ovarian cancer research
New clues to early detection and personalized treatment of ovarian cancer have been made by researchers. Ovarian cancer is currently one of the most difficult cancers to diagnose early due to the lack of symptoms that are unique to the illness. Successful treatment is difficult at this late stage, resulting in high mortality rates.
Stem cells show promise for stroke in pilot study
A stroke therapy using stem cells extracted from patients’ bone marrow has shown promising results in the first trial of its kind in humans. The therapy uses a type of cell called CD34+ cells, a set of stem cells in the bone marrow that give rise to blood cells and blood vessel lining cells. Rather than developing into brain cells themselves, the cells are thought to release chemicals that trigger the growth of new brain tissue and new blood vessels in the area damaged by stroke.

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