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The X-ray Crystallography Core provides instrumentation for the determination of crystal structures using X-ray diffraction techniques. Central to this technique is the ability to rapidly collect X-ray diffraction data from macromolecular crystals in order to elucidate their molecular three-dimensional structure. This approach is being used by several UMMS laboratories to illuminate the atomic-level functioning of macromolecular in cells including uncovering contributions of protein molecules to disease processes and the analysis of important drug targets.
Facilities are housed on the 9th floor of the Lazare Research Building (LRB) and on the 1st floor of Biotech II. The system in Biotech II is comprised of an RU300HR X-ray generator, Osmic optics, a MAR Image Plate System and an Oxford liquid nitrogen cryogenic crystal cooler. The LRB facility includes the newest instrument (pictured below) which was purchased in 2012 from Rigaku using an NIH Shared Instrumentation Grant supplemented by UMMS funds. This is a state-of-the-art X-ray crystallographic system including a MicroMax-007 HF Microfocus rotating anode X-ray generator, Osmic optics and a Saturn HG CCD detector mounted on an AFC11 4-axis goniometer. Sample crystals can be cooled to -180˚C with a CSCOBRA Cryogenic system. This system permits very rapid and accurate diffraction data collection.
UMMS scientists interested in the X-ray Crystallography Core Facilities may contact the Core director, Dr. William Royer (William.Royer@umassmed.edu) for more information.