Radiological Physics - Select Publications

Gounis MJ, Vedantham S, Weaver JP, Puri AS, Brooks CS, Wakhloo AK, Bogdanov AA. Myeloperoxidase in human intracranial aneurysms: preliminary evidence. Stroke. 2014 May;45(5):1474-7. doi: 10.1161/STROKEAHA.114.004956. Epub 2014 Apr 8.

Jon AF, Cheema AR, Khan AN, Raptopoulos V, Hauser T, Nasser I, Welty FK, Karellas A, Clouse ME. Assessment of liver fat in an obese patient population using noncontrast CT fat percent index. Clin Imaging. 2014 May-Jun;38(3):259-64. doi: 10.1016/j.clinimag.2014.01.005. Epub 2014 Jan 17.

Marya N, Karellas A, Foley A, Roychowdhury A, Cave D. Computerized 3-dimensional localization of a video capsule in the abdominal cavity: validation by digital radiography. Gastrointest Endosc. 2014 Apr;79(4):669-74. doi: 10.1016/j.gie.2013.11.022. Epub 2014 Jan 11.

Vedantham S, Shi L, Karellas A, O'Connell AM, Conover DL. Personalized estimates of radiation dose from dedicated breast CT in a diagnostic population and comparison with diagnostic mammography. Phys Med Biol. 2013 Nov 21;58(22):7921-36. doi: 10.1088/0031-9155/58/22/7921. Epub 2013 Oct 29.

van der Bom IM, Hou SY, Puri AS, Spilberg G, Ruijters D, van de Haar P, Carelsen B, Vedantham S, Gounis MJ, Wakhloo AK. Reduction of coil mass artifacts in high-resolution flat detector conebeam CT of cerebral stent-assisted coiling. AJNR Am J Neuroradiol. 2013 Nov-Dec;34(11):2163-70. doi: 10.3174/ajnr.A3561. Epub 2013 May 30.

Aberle DR, DeMello S, Berg CD, Black WC, Brewer B, Church TR, Clingan KL, Duan F, Fagerstrom RM, Gareen IF, Gatsonis CA, Gierada DS, Jain A, Jones GC, Mahon I, Marcus PM, Rathmell JM, Sicks J; National Lung Screening Trial Research Team (including Karellas A). Results of the two incidence screenings in the National Lung Screening Trial. N Engl J Med. 2013 Sep 5;369(10):920-31. doi: 10.1056/NEJMoa1208962.

Vedantham S, Karellas A, Emmons MM, Moss LJ, Hussain S, Baker SP. Dedicated breast CT: geometric design considerations to maximize posterior breast coverage. Phys Med Biol. 2013 Jun 21;58(12):4099-118. doi: 10.1088/0031-9155/58/12/4099. Epub 2013 May 17.

Vedantham S, Karellas A. X-ray phase contrast imaging of the breast: analysis of tissue simulating materials. Med Phys. 2013 Apr;40(4):041906. doi: 10.1118/1.4794503.

Shi L, Vedantham S, Karellas A, O'Connell AM. Technical note: Skin thickness measurements using high-resolution flat-panel cone-beam dedicated breast CT. Med Phys. 2013 Mar;40(3):031913. doi: 10.1118/1.4793257.

Noo F, Karellas AFocus series introduction. X-ray computed tomography: 2012 advances in image formation. Med Phys. 2013 Mar;40(3):031001. doi: 10.1118/1.4794317

Lange J, Karellas A, Street J, Eck JC, Lapinsky A, Connolly PJ, Dipaola CP. Estimating the effective radiation dose imparted to patients by intraoperative cone-beam computed tomography in thoracolumbar spinal surgery. Spine (Phila Pa 1976). 2013 Mar 1;38(5):E306-12. doi: 10.1097/BRS.0b013e318281d70b.

Kanal KM, Krupinski E, Berns EA, Geiser WR, Karellas A, Mainiero MB, Martin MC, Patel SB, Rubin DL, Shepard JD, Siegel EL, Wolfman JA, Mian TA, Mahoney MC. ACR-AAPM-SIIM practice guideline for determinants of image quality in digital mammography. J Digit Imaging. 2013 Feb;26(1):10-25. doi: 10.1007/s10278-012-9521-3.

Vedantham S, Shi L, Glick SJ, Karellas A. Scaling-law for the energy dependence of anatomic power spectrum in dedicated breast CT. Med Phys. 2013 Jan;40(1):011901. doi: 10.1118/1.4769408.

Vedantham S, Shi L, Karellas A, O'Connell AM. Dedicated breast CT: fibroglandular volume measurements in a diagnostic population. Med Phys. 2012 Dec;39(12):7317-28. doi: 10.1118/1.4765050.

D'Orsi CJ, Getty DJ, Pickett RM, Sechopoulos I, Newell MS, Gundry KR, Bates SR, Nishikawa RM, Sickles EA, Karellas A, D'Orsi EM. Stereoscopic digital mammography: improved specificity and reduced rate of recall in a prospective clinical trial. Radiology. 2013 Jan;266(1):81-8. doi: 10.1148/radiol.12120382.

Jones BL, Manohar N, Reynoso F, Karellas A, Cho SH. Experimental demonstration of benchtop x-ray fluorescence computed tomography (XFCT) of gold nanoparticle-loaded objects using lead- and tin-filtered polychromatic cone-beams. Phys Med Biol. 2012 Dec 7;57(23):N457-67. doi: 10.1088/0031-9155/57/23/N457. Epub 2012 Nov 8.

Karellas A. Photon-counting digital mammography: evaluation of performance under clinically relevant conditions. Acad Radiol. 2012 Aug;19(8):913-5. doi: 10.1016/j.acra.2012.05.007.

Vedantham S, Shi L, Karellas A, Noo F. Dedicated breast CT: radiation dose for circle-plus-line trajectory. Med Phys. 2012 Mar;39(3):1530-41. doi: 10.1118/1.3688197.

Yngvesson SK, St Peter B, Siqueira P, Kelly P, Glick S, Karellas A, Khan A. Feasibility demonstration of frequency domain terahertz imaging in breast cancer margin determination. Proc Soc Photo Opt Instrum Eng. 2012 Feb 9;8221. doi: 10.1117/12.907075.

Vedantham S, Shi L, Karellas A, Michaelsen KE, Krishnaswamy V, Pogue BW, Paulsen KD. Semi-automated segmentation and classification of digital breast tomosynthesis reconstructed images. Conf Proc IEEE Eng Med Biol Soc. 2011;2011:6188-91. doi: 10.1109/IEMBS.2011.6091528.

National Lung Screening Trial Research Team (including Karellas A), Aberle DR, Adams AM, Berg CD, Black WC, Clapp JD, Fagerstrom RM, Gareen IF, Gatsonis C, Marcus PM, Sicks JD. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med. 2011 Aug 4;365(5):395-409. doi: 10.1056/NEJMoa1102873. Epub 2011 Jun 29.

Noo F, Karellas A. X-ray computed tomography: advances in image formation. Med Phys. 2011 Jul;38 Suppl 1:S1.

Bliznakova K, Suryanarayanan S, Karellas A, Pallikarakis N. Evaluation of an improved algorithm for producing realistic 3D breast software phantoms: application for mammography. Med Phys. 2010 Nov;37(11):5604-17.

National Lung Screening Trial Research Team (including Karellas A), Aberle DR, Berg CD, Black WC, Church TR, Fagerstrom RM, Galen B, Gareen IF, Gatsonis C, Goldin J, Gohagan JK, Hillman B, Jaffe C, Kramer BS, Lynch D, Marcus PM, Schnall M, Sullivan DC, Sullivan D, Zylak CJ. The National Lung Screening Trial: overview and study design. Radiology. 2011 Jan;258(1):243-53. doi: 10.1148/radiol.10091808. Epub 2010 Nov 2.

Vedantham S, Karellas A. Modeling the performance characteristics of computed radiography (CR) systems. IEEE Trans Med Imaging. 2010 Mar;29(3):790-806. doi: 10.1109/TMI.2009.2036995.

Karathanasis E, Suryanarayanan S, Balusu SR, McNeeley K, Sechopoulos I, Karellas A, Annapragada AV, Bellamkonda RV. Imaging nanoprobe for prediction of outcome of nanoparticle chemotherapy by using mammography. Radiology. 2009 Feb;250(2):398-406. doi: 10.1148/radiol.2502080801.

Karellas A, Vedantham S. Breast cancer imaging: a perspective for the next decade. Med Phys. 2008 Nov;35(11):4878-97.

Karellas A, Lo JY, Orton CG. Point/Counterpoint. Cone beam x-ray CT will be superior to digital x-ray tomosynthesis in imaging the breast and delineating cancer. Med Phys. 2008 Feb;35(2):409-11.

Sechopoulos I, Vedantham S, Suryanarayanan S, D'Orsi CJ, Karellas A. Monte Carlo and phantom study of the radiation dose to the body from dedicated CT of the breast. Radiology. 2008 Apr;247(1):98-105. doi: 10.1148/radiol.2471071080. Epub 2008 Feb 21.

Sechopoulos I, Suryanarayanan S, Vedantham S, D'Orsi CJ, Karellas A. Radiation dose to organs and tissues from mammography: Monte Carlo and phantom study. Radiology. 2008 Feb;246(2):434-43. Epub 2007 Dec 4.

Suryanarayanan S, Karellas A, Vedantham S, Sechopoulos I, D'Orsi CJ. Detection of simulated microcalcifications in a phantom with digital mammography: effect of pixel size. Radiology. 2007 Jul;244(1):130-7. Epub 2007 May 23.

Karellas A. Mammographic pattern analysis: an emerging risk assessment tool. Acad Radiol. 2007 May;14(5):511-2.

Sechopoulos I, Suryanarayanan S, Vedantham S, D'Orsi CJ, Karellas A. Scatter radiation in digital tomosynthesis of the breast. Med Phys. 2007 Feb;34(2):564-76.

Sechopoulos I, Suryanarayanan S, Vedantham S, D'Orsi C, Karellas A. Computation of the glandular radiation dose in digital tomosynthesis of the breast. Med Phys. 2007 Jan;34(1):221-32.

Suryanarayanan S, Karellas A, Vedantham S, Sechopoulos I. Theoretical analysis of high-resolution digital mammography. Phys Med Biol. 2006 Jun 21;51(12):3041-55. Epub 2006 May 31.

Suryanarayanan S, Karellas A, Vedantham S, Onishi SK. High-resolution imager for digital mammography: physical characterization of a prototype sensor. Phys Med Biol. 2005 Sep 7;50(17):3957-69. Epub 2005 Aug 11.

Suryanarayanan S, Karellas A, Vedantham S, Waldrop SM, D'Orsi CJ. Detection of simulated lesions on data-compressed digital mammograms. Radiology. 2005 Jul;236(1):31-6. Epub 2005 Jun 27.

Suryanarayanan S, Karellas A, and Vedantham S. Physical Characteristics of a Full-field Digital Mammography System. Nucl Instrum Methods Phys Res A. 2004 Nov 11;533(3):560-570.

Vedantham S, Karellas A, Suryanarayanan S, Onishi SK. Solid-state fluoroscopic imager for high-resolution angiography: physical characteristics of an 8 cm x 8 cm experimental prototype. Med Phys. 2004 Jun;31(6):1462-72.

Suryanarayanan S, Karellas A, Vedantham S, Waldrop SM, D'Orsi CJ. A perceptual evaluation of JPEG 2000 image compression for digital mammography: contrast-detail characteristics. J Digit Imaging. 2004 Mar;17(1):64-70.

Vedantham S, Karellas A, Suryanarayanan S. Solid-state fluoroscopic imager for high-resolution angiography: parallel-cascaded linear systems analysis. Med Phys. 2004 May;31(5):1258-68.

Vedantham S, Karellas A, Suryanarayanan S. Attenuation characteristics of fiberoptic plates for digital mammography and other X-ray imaging applications. J Xray Sci Technol. 2003 Jan 1;11(4):219-30.

Suryanarayanan S, Karellas A, Vedantham S, Ved H, Baker SP, D'Orsi CJ. Flat-panel digital mammography system: contrast-detail comparison between screen-film radiographs and hard-copy images. Radiology. 2002 Dec;225(3):801-7.

Kleinman PK, O'Connor B, Nimkin K, Rayder SM, Spevak MR, Belanger PL, Getty DJ, Karellas A. Detection of rib fractures in an abused infant using digital radiography: a laboratory study. Pediatr Radiol. 2002 Dec;32(12):896-901. Epub 2002 Aug 8.

Lewin JM, D'Orsi CJ, Hendrick RE, Moss LJ, Isaacs PK, Karellas A, Cutter GR. Clinical comparison of full-field digital mammography and screen-film mammography for detection of breast cancer. AJR Am J Roentgenol. 2002 Sep;179(3):671-7.

Suryanarayanan S, Karellas A, and Vedantham S. Theoretical Analysis of Hybrid Flat-panel Detector Arrays for Digital Fluoroscopy: General System Architecture, Signal, and Noise Processes. IEEE Sensors J. 2001 Aug;1(2):168-74.

Suryanarayanan S, Karellas A, Vedantham S, Baker SP, Glick SJ, D'Orsi CJ, Webber RL. Evaluation of linear and nonlinear tomosynthetic reconstruction methods in digital mammography. Acad Radiol. 2001 Mar;8(3):219-24.

Lewin JM, Hendrick RE, D'Orsi CJ, Isaacs PK, Moss LJ, Karellas A, Sisney GA, Kuni CC, Cutter GR. Comparison of full-field digital mammography with screen-film mammography for cancer detection: results of 4,945 paired examinations. Radiology. 2001 Mar;218(3):873-80.

Suryanarayanan S, Karellas A, Vedantham S, Glick SJ, D'Orsi CJ, Baker SP, Webber RL. Comparison of tomosynthesis methods used with digital mammography. Acad Radiol. 2000 Dec;7(12):1085-97.

Vedantham S, Karellas A, Suryanarayanan S, D'Orsi CJ, Hendrick RE. Breast imaging using an amorphous silicon-based full-field digital mammographic system: stability of a clinical prototype. J Digit Imaging. 2000 Nov;13(4):191-9.

Vedantham S, Karellas A, Suryanarayanan S, Levis I, Sayag M, Kleehammer R, Heidsieck R, D'Orsi CJ. Mammographic imaging with a small format CCD-based digital cassette: physical characteristics of a clinical system. Med Phys. 2000 Aug;27(8):1832-40.

Liu H, Jiang H, Fajardo LL, Karellas A, Chen WR. Lens distortion in optically coupled digital x-ray imaging. Med Phys. 2000 May;27(5):906-12.

Vedantham S, Karellas A, Suryanarayanan S, Albagli D, Han S, Tkaczyk EJ, Landberg CE, Opsahl-Ong B, Granfors PR, Levis I, D'Orsi CJ, Hendrick RE. Full breast digital mammography with an amorphous silicon-based flat panel detector: physical characteristics of a clinical prototype. Med Phys. 2000 Mar;27(3):558-67.

D'Orsi CJ, Karellas A. For mammography, it's digital vs. screen-film. Diagn Imaging (San Franc). 1999 Nov;Suppl Digital:D16-8.

Rothenberg LN, Nath R, Price RR, Hall TJ, Karellas A, Sobol WT, Yester MV, Zimmerman RE. The American Association of Physicists in medicine. A perspective on the new millennium. Radiology. 1998 Dec;209(3):600-3. No abstract available.

Raptopoulos V, Baum JK, Hochman M, Karellas A, Houlihan MJ, D'Orsi CJ. High resolution CT mammography of surgical biopsy specimens. J Comput Assist Tomogr. 1996 Mar-Apr;20(2):179-84.

Diamond DA, Kleinman PK, Spevak M, Nimkin K, Belanger P, Karellas A. The tailored low dose fluoroscopic voiding cystogram for familial reflux screening. J Urol. 1996 Feb;155(2):681-2.

D'Orsi CJ, Karellas A. On line for digital mammography. Lancet. 1995 Jul 29;346(8970):263-4.

Dwyer SJ 3rd, Boehme JM, Cox GG, Huynh PT, Karellas A, Stewart BK, Vannier MW, Williams MB. Computer applications and digital imaging. Radiology. 1995 Feb;194(2):616-8.

Liu H, Karellas A, Harris LJ, D'Orsi CJ. Methods to calculate the lens efficiency in optically coupled CCD x-ray imaging systems. Med Phys. 1994 Jul;21(7):1193-5.

Kleinman PK, Diamond DA, Karellas A, Spevak MR, Nimkin K, Belanger P. Tailored low-dose fluoroscopic voiding cystourethrography for the reevaluation of vesicoureteral reflux in girls. AJR Am J Roentgenol. 1994 May;162(5):1151-4; discussion 1155-6.

Davidoff A, Reuter K, Karellas A, Baker SP, Raptopoulos V. Maternal umbilicus: ultrasound window to the gravid uterus. J Clin Ultrasound. 1994 May;22(4):263-7.

Karellas A, Liu H, Harris LJ, D'Orsi CJ. Digital mammo delivers quick, reliable images. Diagn Imaging (San Franc). 1994 Feb;16(2):77-80.

Karellas A, Harris LJ, Liu H, Davis MA, D'Orsi CJ. Charge-coupled device detector: performance considerations and potential for small-field mammographic imaging applications. Med Phys. 1992 Jul-Aug;19(4):1015-23.

Raptopoulos V, Karellas A, Bernstein J, Reale FR, Constantinou C, Zawacki JK. Value of dual-energy CT in differentiating focal fatty infiltration of the liver from low-density masses. AJR Am J Roentgenol. 1991 Oct;157(4):721-5.

Costanza ME, D'Orsi CJ, Greene HL, Gaw VP, Karellas A, Zapka JG. Feasibility of universal screening mammography. Lessons from a community intervention. Arch Intern Med. 1991 Sep;151(9):1851-6.

Agren M, Karellas A, Leahey D, Marks S, Baran D. Ultrasound attenuation of the calcaneus: a sensitive and specific discriminator of osteopenia in postmenopausal women. Calcif Tissue Int. 1991 Apr;48(4):240-4.

Kleinman PK, Belanger PL, Karellas A, Spevak MR. Normal metaphyseal radiologic variants not to be confused with findings of infant abuse. AJR Am J Roentgenol. 1991 Apr;156(4):781-3.

Gaw VP, Bush SM, D'Orsi CJ, Costanza ME, Karellas A, Dowd M, Zapka JG. A program to improve mammography skills of practicing radiologic technologists. QRB Qual Rev Bull. 1991 Feb;17(2):48-53.

Baran D, Sorensen A, Grimes J, Lew R, Karellas A, Johnson B, Roche J. Dietary modification with dairy products for preventing vertebral bone loss in premenopausal women: a three-year prospective study. J Clin Endocrinol Metab. 1990 Jan;70(1):264-70.

Kleinman PK, Blackbourne BD, Marks SC, Karellas A, Belanger PL. Radiologic contributions to the investigation and prosecution of cases of fatal infant abuse. N Engl J Med. 1989 Feb 23;320(8):507-11.

D'Orsi CJ, Karellas A, Costanza ME, Gaw VP. Preliminary report of an intervention to improve mammography skills of radiologists. Prog Clin Biol Res. 1989;293:151-7.

Baran DT, Kelly AM, Karellas A, Gionet M, Price M, Leahey D, Steuterman S, McSherry B, Roche J. Ultrasound attenuation of the os calcis in women with osteoporosis and hip fractures. Calcif Tissue Int. 1988 Sep;43(3):138-42.

Raptopoulos V, Davidoff A, Karellas A, Davis MA, Coolbaugh BL, Smith EH. CT of the pancreas with a fat-density oral contrast regimen. AJR Am J Roentgenol. 1988 Jun;150(6):1303-6.

Raptopoulos V, Davis MA, Davidoff A, Karellas A, Hays D, D'Orsi CJ, Smith EH. Fat-density oral contrast agent for abdominal CT. Radiology. 1987 Sep;164(3):653-6.

Raptopoulos V, Smith EH, Karellas A, Miranda DK, Tefft CA. Daytime constancy of bile duct diameter. AJR Am J Roentgenol. 1987 Mar;148(3):557-8.

Raptopoulos V, Smith EH, Cummings T, Silva W, Karellas A. Bile-duct dilatation after laparotomy: a potential effect of intestinal hypomotility. AJR Am J Roentgenol. 1986 Oct;147(4):729-31.

Raptopoulos V, Fabian TM, Silva W, D'Orsi CJ, Karellas A, Compton CC, Krolikowski FJ, Doherty P, Smith EH. The effect of time and cholecystectomy on experimental biliary tree dilatation. A multi-imaging evaluation. Invest Radiol. 1985 May-Jun;20(3):276-86.