Interventional Neuroradiology Division


The mission of the Division of Neurointervention is to provide comprehensive cerebrovascular services to New England including diagnostic catheter angiography, endovascular neurosurgery of neurovascular diseases, and minimally invasive treatment of degenerative spine disease. The Division attains excellence in patient care from a dedicated team of professionals by state-of-the-art clinical practices developed through a cutting-edge clinical and translational research program with emphases in neuroimaging, endovascular device development and techniques in image guided surgery. Our first responsibility is to the patients and their families, ensuring they receive the best healthcare possible. We are dedicated to providing rigorous education to our trainees in order to produce knowledgeable, compassionate and technically competent clinicians. We are respectful and supportive of our team, whose diligent efforts and contributions facilitate our research and service goals.

Key Technologies

Along with excellent departmental neuroimaging resources, the Division is home to the latest bi-plane angiosurgical equipment available (Allura FD 20/20). In addition to flat-panel detector technology enabling high spatial and temporal resolution; 3-dimensional catheter angiography, cone-beam CT, image guidance software and a number of advanced vascular analysis software are all routinely employed to improve procedural outcomes. Recently, UMASS announced the purchase of a second bi-plane flat panel angiography system to improve availability of neuroendovascular services. Complementary to state-of-the-art imaging resources, all commercialized neurointerventional devices are readily available to the Division’s physicians due to extensive clinical research that provides cutting-edge technology prior to widespread distribution.

Importantly, the clinical imaging system is replicated in the Division’s translational research laboratory, The New England Center for Stroke Research . This deliberate arrangement of a dedicated research imaging system enables technologies, both with regard to imaging and interventional devices, to be tested and validated in a preclinical laboratory prior to implementation in the clinic. Additionally, physicians from around the world (more than 100 per year) are trained in new techniques, imaging tools and interventional devices in NECStR.


Ajay K. Wakhloo, MD, PhD (Division Chief)

Samuel Hou, MD (Fellow)

Mary Peras (NP)

Donna Soja (NP)

Anne McKee

Charlene Franz (Clinical Research Coordinator)

Matthew Moriarty (RT)

Matthew J Gounis, PhD (Research)

Specific Procedures

  • Acute ischemic and hemorrhagic stroke
  • Brain and spinal tumor embolizations
  • Brain aneurysms
  • Brain arteriovenous malformations
  • Carotid and intracranial stenting
  • Central retinal artery and venous thrombosis
  • Diagnostic cerebral and spinal angiography
  • Dural arteriovenous fistulas
  • Hemangioma and birth marks
  • Kyphoplasty
  • Nosebleeds (epistaxis)
  • Pain treatment
  • Pediatric brain vascular malformations
  • Spinal vascular malformations
  • Traumatic cerebrovascular injuries
  • Vertebroplasty


    1. Gounis MJ, De Leo MJ III, Wakhloo AK. Advances in Interventional Neuroradiology 2009. Stroke 2010
    2. Wakhloo AK, Gounis MJ. Retrievable closed-cell intracranial stent for foreign body and clot removal. Neurosurgery 62 (5 Suppl 2): ONS390-ONS393, 2008
    3. Gounis MJ, Lieber BB, Webster KA, Wakhloo AK. A novel angiographic methodology for the quantification of angiogenesis. IEEE Trans Biomed Eng 55:996-1003, 2008
    4. Wakhloo AK, Mandell J, Gounis MJ, Brooks C, Linfante I, Winer J, Weaver JP. Stent-assisted reconstructive endovascular repair of cranial fusiform atherosclerotic and dissecting aneurysms: long-term clinical and angiographic follow-up. Stroke 39:3288-3296, 2008
    5. Grad Y, Sievert H, Nishri B, Stone GW, Katzen BT, Yodfat O, Higashida R, Harris D, Wakhloo AK, Assaf Y, Norbash A, Bushi D, Lieber BB. A novel endovascular device for emboli rerouting: Part I: Evaluation in a swine model. Stroke 39:2860-2866, 2008
    6. Linfante I, Delgado-Mederos R, Andreone V, Gounis M, Hendricks L, Wakhloo AK. Angiographic and hemodynamic effect of high concentration of intra-arterial nicardipine infusion in cerebral vasospasm. Neurosurgery 63:1080-1087, 2008
    7. Linfante I, Andreone V, Akkawi N, Wakhloo AK. Internal carotid artery stenting in patients over 80 years of age: single-center experience and review of the literature. J Neuroimaging 2008 (Epub ahead of print)
    8. Cesar L, Miskolczi L, Lieber BB, Sadasivan C, Gounis MJ, Wakhloo AK. Neurological deficits associated with the elastase-induced aneurysm model in rabbits. Neurol Res 31:414-419, 2009
    9. Sadasivan C, Cesar L, Seong J, Rakian A, Hao Q, Tio F, Wakhloo AK, Lieber BB. An original flow diversion device for the treatment of intracranial aneurysms. Evaluation in the rabbit elastase-induced model. Stroke 40:952-958, 2009
    10. Chueh J, JC Ford JC, Wakhloo AK, Gounis MJ. Neurovascular modeling: Small batch manufacturing of silicone vascular replicas. AJNR Am J Neuroradiol 30:1158-1164, 2009
    11. Sadasivan C, Cesar L, Seong, J, Wakhloo AK, Lieber BB. Treatment of rabbit elastase-induced aneurysm models by flow diverters: Development of quantifiable indices of device performance using digital subtraction angiography. IEEE Trans Med Imaging 28:1117-1125, 2009
    12. Wakhloo AK, DeLeo MJ 3rd, Brown MM. Advances in interventional neuroradiology [Editorial]. Stroke 40:e305-e312, 2009
    13. Wakhloo AK. Endovascular treatment of dural carotid cavernous sinus fistulas [Editorial]. J Neuroophthalmol 29:1-2, 2009
    14. Fisher M, Feuerstein G, Howells DW, Hurn PD, Kent TA, Savitz SI, Lo EH for the STAIR Group. Update of the stroke therapy academic industry roundtable preclinical recommendations [Special report]. Stroke 40:2244- 2250, 2009
    15. DeLeo III DJ, Gounis MJ, Hong B, Ford JC, Wakhloo AK, Bogdanov Jr AA. Carotid artery brain aneurysm model: in vivo molecular enzyme-specific MR Imaging of active inflammation in a pilot study. Radiology 252:696-703, 2009
    16. Linfante I, DeLeo III M, Gounis M, Brooks C, Wakhloo AK. Cerecyte versus platinum coils in the treatment of intracranial aneurysms: Packing Density, clinical and angiographic mid-term results. AJNR Am J Neuroradiol 30: 1496-1501, 2009
    17. Hong B, Deleo III MJ, Patel NV, Gounis MJ, Linfante I, Wojak JC, Wakhloo AK. The semi-jailing technique for stent-assisted coil embolization of complex, wide-necked intracranial aneurysms. Neurosurgery 65(6):1131-1139, 2009