Study Participants Wanted

Note: Only studies being conducted by the UMass Department of Psychiatry will be listed here. No other entries accepted.

Members of the department wishing to submit information like this should use the format below, include a subject line of “Study Participants Wanted,” and email it to psychiatrycommunications@umassmed.edu.

Vitamin D Supplementation and Bipolar Depression

Bipolar depression is well known to be difficult to treat. Many of the medications used can have unpleasant side effects. Finding a well tolerated and safe option that would decrease symptoms of depression in bipolar disorder would help many people. Vitamin D is often low in people with depression, including bipolar depression. Vitamin D supplementation has been shown in many studies to help reduce depression symptoms in people with non-bipolar depression.

The goal of this research is to see if Vitamin D supplementation in people with bipolar disorder is associated with improved mood, in particular less depression.

This study will monitor mood symptoms and Vitamin D levels over the course of 12 weeks.

Participants are:

  • 25-70 years old
  • Diagnosed with bipolar disorder
  • Currently feeling down, sad, or depressed
  • Low Vitamin D levels (evaluated by blood work at first study visit)

Participants will receive financial compensation as well study-related evaluations at no cost.

For more information, please contact the research study coordinator Jessica Penny at 508-334-7352 or Principal Investigator Wendy Marsh, M.D. at 508-856-5071.

Docket # H00000800


A Research Study on Treatment of Marijuana Use and Schizophrenia

The UMass Psychotic Disorders Research Program is running a NIH-funded study on marijuana abuse and schizophrenia.

People who have schizophrenia often abuse marijuana. We are studying whether an FDA approved Clozapine can reduce marijuana use.

The study last about 14 weeks and involves:

  • Weekly meetings with the research staff
  • Answering questions about substance use and current symptoms
  • Half the people in the study will get a medicine called “clozapine” and the other half will get a medicine called “risperidone”.

People in the study will not know which type of pill they are getting.

We are looking for people who:

  • Have been told they have schizophrenia
  • Are willing to take medicine for schizophrenia
  • Use marijuana regularly
  • Are ages 18-55

People in the study will be compensated for their time. All information is kept private.
If you are interested and would like more information, please call Radhika Natarajan at 508-856-8323 or email: Radhika.Natarajan@umassmed.edu.

Docket # H-00001171


The Psychotic Disorders Program at UMass Medical School is happy to share with you a NIH-funded study entitled Salsalate as an Adjunctive Treatment in Patients with Schizophrenia.

This is an open-label 12-week pilot research study examining how salsalate, an anti-inflammatory drug affects positive and negative symptoms of schizophrenia, Hemoglobin A1c, fasting glucose, other metabolic issues and cognitive functioning when added to an antipsychotic medication. We are seeking your help to recruit eligible subjects.

Inclusion Criteria
• M/F, Age 18-65 years
• Diagnosis of schizophrenia or schizoaffective disorder
• Currently on a stable dose of antipsychotic medication (for at least one month)

Exclusion Criteria
• Current substance abuse
• Significant medical illnesses including uncontrolled hypertension, diabetes, seizure disorder, severe cardiovascular, cerebrovascular, pulmonary or thyroid diseases.
• Currently on immunosuppressant medication including oral steroids.
• Use of anti-coagulants.

Subjects will be compensated for their time.

If you would like to refer potential research subjects, please contact the Research Coordinator, Radhika Natarajan, at 508-856-8323 or via e-mail at Radhika.Natarajan@umassmed.edu.
Docket # H-14814


Research Study Needs Male Participants With ADHD

Young men with ADHD are needed for a research study looking at brain function. Participants may qualify if:

  • They are between 14 -24 years old
  • They have ADHD
  • They are right-handed

We need both smokers and non-smokers for this study, so tobacco smokers are encouraged to apply! Participants will complete questionnaires and have 1 non-invasive MRI imaging scan. Compensation (up to $130) will be provided.

If you are interested in participating, or would like more information, please contact us:

Phone: 508-856-8185
Email:
CCNI.Research@umassmed.edu  

UMass Medical School
UMMS IRB Docket # H-14119


Ongoing Perinatal Depression Research Studies

  1. Hormones in Pregnancy and Brain Imaging in Postpartum Depression Research Study
    This NIH-funded study will monitor for symptoms of depression and anxiety during late pregnancy (2 visits) and after giving birth (3 visits). We also monitor blood hormone levels (each visit) and in the postpartum, participants will have one brain MRI scan done. Total participation is about 4-7 hours.
    Participants in this study:
    • are 18-40 years old and pregnant
    • are either: healthy without mood symptoms OR have some symptoms of depression or anxiety/stress
    • plan to give birth at UMass Memorial Medical Center
    • are not taking an antidepressant or steroid medication
    Participants will receive financial compensation as well study-related evaluations at no cost. Participants who complete the MRI brain scan will also receive a picture of their brain MRI scan.
    To learn more, please contact the study doctor, Kristina M. Deligiannidis, M.D. @ 508-856-5928.
    Docket # H-00001214

  2. Sex Hormones and Brain Imaging in Postpartum Depression Study 
    Participants will complete a single postpartum study visit which will include a full psychiatric assessment, one blood and urine sample and a brain MRI to identify how sex hormones affect brain circuitry in postpartum depression. Compensation is provided.
    (UMMS #H-14373)

Contact Dr. Kristina Deligiannidis @ 508-334-7262


National Institute of Mental Health (NIMH)
Sustaining Remission of Psychotic Depression Study

Patients that are currently suffering from depression with irrational worries are invited to participate in a research study to determine how long people need to stay on an antipsychotic medication after they recover from their symptoms. Study participation will last up to 20 weeks and patients will receive a combination of an antipsychotic medication and an antidepressant medication. Patients must be:
• 18 to 85 years of age
• experiencing symptoms of depression with irrational worries
• not be pregnant
Patients will receive study medication and study-related care at no cost. Qualifying patients will be eligible to participate in 9-month follow-up study. Compensation provided.
Contact Jessica Penny @ 508-334-7352
Docket # H-14207


A new research study at UMass Medical Center is exploring the links between opioid addiction and chronic pain.

This study will identify the differences in physiological, behavioral and emotional reactivity to pain among full (methadone) or partial (buprenorphine) mu-agonist maintained patients, patients with an opioid use history but sustained abstinence, and healthy controls. This is a one visit study that takes about an hour and participants are compensated for their time upon completion.

Below are the major inclusion criteria:
Be between 18 and 65 yrs. old
Have chronic pain
Be on ONE of the following for opioid dependence:
o Methadone
o Buprenorphine (Suboxone)
OR
o Have no opioid use for at least 6 months

For more information contact Padma Sankaran (508-334-2153) or Dr. Amy Wachholtz (508-334-2164).
IRB# H-13904.


The UMass Psychotic Disorders Research Program is running an NIH-funded study to investigate whether the combination of risperidone and desipramine is effective in reducing alcohol consumption in individuals suffering from schizophrenia and ongoing alcohol drinking. Below are the major inclusion and exclusion criteria:

Inclusion criteria:  Age 18-65; Suffers from schizophrenia or schizoaffective disorder; Meets diagnostic criteria for current alcohol abuse or dependence
Exclusion Criteria:  Suffers from any substance abuse disorder other than caffeine, nicotine, and cannabinoid containing substances; Continues to use alcohol despite treatment with medications such as naltrexone, acamprosate, disulfiram, topiramate, etc.
For more information contact Dr. Xiaoduo Fan (508-856-3881), Dr. Amy Harrington (508-860-1260), or Matthew Goodnow (508-856-2494). 
Docket #H-14857


The Department of Psychiatry at the University of Massachusetts Medical School, UMass Memorial Health Care is recruiting subjects for the following studies:

Brain Imaging: A Research Study for Boys with an Autism Spectrum Disorder or Typical Development
Males between 13 & 17 years of age.
Typically Developing or with Autism, Asperger’s Disorder, or Pervasive Developmental Disorder NOS
Participants will receive a MRI scan, a brief neurocognitive evaluation and interview with one or more clinicians.
Compensation will be provided for time and travel.
Contact: The Child & Adolescent NeuroDevelopment Initiative (CANDI).
Phone: 508-856-5896 or E-mail: ChildResearch@umassmed.edu.
Visit us on the web at: http://www.umassmed.edu/psychiatry/candi/index.aspx 
Docket # H-14247


Recruiting male adolescents both with and without any history of substance abuse for a study of personality, the brain, and substance use
Male adolescents who speak English ages 15-21 years.
No history of substance abuse - minor substance and alcohol use is okay.
OR currently receiving treatment or counseling for substance use.
Participants will be screened for personality, substance use issues, and eligibility to receive a MRI (for example, no metal can be in the body), participate in an interview lasting 60 to 90 minutes and, at a later date, go to UMMS to complete some tasks while getting a MRI.
Participants will receive a $15 gift card at the interview and a $50 gift card at the MRI scan. The MRI lasts 45 minutes. The whole trip could take up to 90 minutes.
Contact: Gina M. Vincent, PhD
Phone: 508- 856-8727 or email Gina.vincent@umassrned.edu.
Docket# H-13454


Investigational Drug Study for Adolescents and Adults with Fragile X Syndrome
Males or females between 16 and 50 years of age with a diagnosis of Fragile X Syndrome.
Eligible participants will receive up to approximately 3 months of investigational drug in the study. During the study, participants will be monitored for side effects and will meet with the study doctor every 3 weeks. Between office visits, caregivers, parents, or guardians will also receive phone calls from the study doctor. At the end of the study, the investigational drug will be gradually withdrawn over a 3-week period. This study will last up to approximately 4 1/2 months and requires up to 8 visits to the University of Massachusetts Medical School and 10 phone calls with the study doctor.
For each visit to the office, a small payment will be offered to offset travel expenses. The investigational drug and all study-related evaluations are provided at no cost.
Contact: The Child & Adolescent NeuroDevelopment Initiative (CANDI).
Phone: 508-856-5896 or email ChildResearch@umassmed.edu.
Visit us on the web at: http://www.umassmed.edu/psychiatry/candi/index.aspx 
Docket# H•14789


Hormones and the Brain: A Research Study for Girls with Bipolar Disorder or Typical Development
Females 6-16 years old and right-handed.
Participants will be part of a brain imaging research study to evaluate the influence of certain hormones on the development of the central nervous system.
Compensation will be provided for time and travel.
Contact: The Child & Adolescent NeuroDevelopment Initiative (CANDI).
Phone: 508-856-5896 or email ChildResearch@umassmed.edu.
Visit us on the web at: http://www.umassmed.edu/psychiatry/candi/index.aspx 
Docket# 13692


ADHD Study
Men aged 14 – 24.
Participants must be diagnosed with ADHD and be right-handed.
Participants will be asked to fill out surveys and undergo a non-invasive MRI scan. No medication is given for this study.
Compensation will be provided for time and travel.
Contact: 508-856-8185 or email CCNI.Research@umassmed.edu.
Docket H-14119


Does Your Child Experience Mood Swings OR Have a Diagnosis of Bipolar Disorder?

Children aged 8 – 17.
Participants MUST Have a diagnosis of Bipolar Disorder OR Experience mood swings AND have a parent with Bipolar Disorder.
Participants will undergo two non-invasive MRI scans, cognitive testing, and take a daily Vitamin D Supplement.
Compensation for time and travel will be provided.
Contact: 508-856-5896 or email us at ChildResearch@umassmed.edu.
UMMS Docket H-13821


Center for Psychopharmacologic Research and Treatment (CPRT)

Hormones in Pregnancy and Brain Imaging in Postpartum Depression Research Study
This NIH-funded study will monitor for symptoms of depression and anxiety during late pregnancy (2 visits) and after giving birth (3 visits). We also monitor blood hormone levels (each visit) and in the postpartum, participants will have one brain MRI scan done. Total participation is about 4-7 hours.
Participants in this study:
• are 18-40 years old and pregnant
• are either: healthy without mood symptoms OR have some symptoms of depression or anxiety/stress
• plan to give birth at UMass Memorial Medical Center
• are not taking an antidepressant or steroid medication
Participants will receive financial compensation as well study-related evaluations at no cost. Participants who complete the MRI brain scan will also receive a picture of their brain MRI scan.
To learn more, please contact the study doctor, Kristina M. Deligiannidis, M.D. @ 508-856-5928.
Docket # H-00001214


BROADENTM Study for Major Depressive Disorder
For participants aged 21 to 70 diagnosed with major depressive disorder.
First depressive episode before age 45.
Tried at least four treatments in current episode of depression with unsatisfactory results.
Taken medications such as Zoloft®, Prozac®, Lexapro®, Wellbutrin®, Paxil®, Effexor®, Cymbalta®, and combinations of these or other medications.
Participated in psychotherapy, cognitive behavioral therapy (CBT), or other talk therapies.
Have tried Vagus nerve stimulation (VNS) or transcranial magnetic stimulation (TMS or rTMS). Have tried Electroconvulsive therapy (ECT).
Are open to considering a surgical option for your depression.
Study-related evaluations at no cost. Compensation provided.
*Caution: Investigational device. Limited by United States law to investigational use.
Contact Chelsea 508-856-5312.
http://www.umassmed.edu/psychopharm/research.aspx  
Docket # H-13482


National Institute of Mental Health (NIMH)

Sustaining Remission of Psychotic Depression Study
For patients who are currently suffering from depression with irrational worries,
21 to 85 years of age and experiencing symptoms of depression with irrational worries.
Cannot be pregnant.
Study-related evaluations and medications at no cost. Compensation provided.
Contact Chelsea Kosma @ 508-856-5312
http://www.umassmed.edu/psychopharm/research.aspx
Docket # H-14207


Brain Imaging and hormone levels in Postpartum Depression Research Study
Research is to see if women who develop postpartum depression have changes in certain hormone levels in the postpartum period which differ from the hormone levels of women who do not become depressed and compare these levels to brain activity.
Consists of one study visit involving the assessment of symptoms of depression and anxiety, taking one blood and urine sample and a having a brain MRI (magnetic resonance imaging) after giving birth.
Must be 18-40 years old and developed postpartum depression within 12 weeks of delivering child, and not currently taking an antidepressant medication or steroid medication.
Study-related evaluations at no cost. Compensation provided.
Contact the research coordinator Nina Jaitly, MD @ 508-334-7880 or by email @ Nina.Jaitly@umassmed.edu or
Principal Investigator Kristina M. Deligiannidis, M.D. @ 508.856.5928 or by email @
Kristina.Deligiannidis@umassmemorial.org
http://www.umassmed.edu/psychopharm/research.aspx  
Docket # H-14373