Preclinical: Rat - Modality: functional connectivity

Heffernan ME, Huang W, Sicard KM, Bratane BT, Sikoglu EM, Zhang N, Fisher M, King JA. Multi-modal approach for investigating brain and behavior changes in an animal model of traumatic brain injury. J Neurotrauma. 2013 Jun 1;30(11):1007-12. doi: 10.1089/neu.2012.2366. Epub 2013 Jun 5.

The composite functional connectivity maps using infralimbic cortex as the seed, for the control group (a) as well as the TBI group 24 h (b), 7 days (c), and 21 days (d) post-surgery. Compared with controls, diminished resting-state functional connectivity (rsFC) in traumatic brain injury (TBI) animals, particularly between infralimbic and the anterior cingulate cortex (ACC), was observed at the initial imaging time point (24 h post-surgery) and normalized thereafter to a similar strength as controls by day 7 post-surgery. This normalization in connectivity remained until day 21.