Translational: human - Modality: structural connectivity - Research Area: nicotine addiction

Huang W, DiFranza JR, Kennedy DN, Zhang N, Ziedonis D, Ursprung S, King JA. Progressive levels of physical dependence to tobacco coincide with changes in the anterior cingulum bundle microstructure. PLoS One. 2013 Jul 4;8(7):e67837. doi: 10.1371/journal.pone.0067837.

The TBSS white matter skeleton (green) is overlaid on the grayscale standard brain. Shadowed red and pink areas are regions of interest, namely left ACb and right ACb. The right side of the brain is shown on the reader's left in the sagittal and coronal views. The faint crosshairs on each image a) coronal, b) sagittal, c) axial) mark the level of the sections on the other views (MNI coordinates [−6.3, 23.5, 21.9]). As depicted in the bar graph, compared to nonsmokers (n = 10), smokers (n = 11) showed significantly higher FA in the right ACb (t(19) = 2.34, p = 0.03) and a trend toward higher FA in the left ACb (t(19) = 2.0, p = 0.06).