Publications

CANDI investigators have published hundreds of papers and book chapters on the phenomenology and treatment of various developmental disorders and techniques for data analysis and management.  A subset of these publications are listed on this page.

Aggression

Aggression.  Meltzer B, Castro M, Frazier JA.  In Martin A, Scahill L, Kratochvil C (eds). Pediatric Psychopharmacology:  Principles and Practice-Second Edition. New York:  Oxford University Press, In Press.

Autism

Frazier, JA, Biederman, J, Bellordre CA, Garfield SB, Geller DA, Coffey BJ, Faraone SV.  Should the diagnosis of Attention Deficit Hyperactivity Disorder be considered in children with pervasive developmental disorder? Journal of Attention Disorders. 2001; 4:203-11.

Language-association cortex asymmetry in autism and specific language impairment. De Fossé L, Hodge SM, Makris N, Kennedy DN, Caviness VS Jr, McGrath L, Steele S, Ziegler DA, Herbert MR, Frazier JA, Tager-Flusberg H, Harris GJ. Ann Neurol. 2004 Dec; 56(6): 757-66.

Bipolar disorder in children with pervasive developmental disorders.  DeJong S, Frazier JA.    In Geller B, DelBello M (eds).  Child and early adolescent bipolar disorder.  New York:  Guilford Publications; 2003. 51-75.

Autism Spectrum Disorders and Schizophrenia.  Dvir Y, Madaan V, Yakutis, L, Frazier JA, Wilson DR. In Ritsner MS (ed). Textbook of Schizophrenia Spectrum Disorders, Volume I: Theoretical Issues, and Neurobiology Research.  New York, NY: Springer, In Press.

Clinical genetic testing for patients with autism spectrum disorders. Shen Y, Dies KA, Holm IA, Bridgemohan C, Sobeih MM, Caronna EB, Miller KJ, Frazier JA, Silverstein I, Picker J, Weissman L, Raffalli P, Jeste S, Demmer LA, Peters HK, Brewster SJ, Kowalczyk SJ, Rosen-Sheidley B, McGowan C, Duda AW, Lincoln SA, Lowe KR, Schonwald A, Robbins M, Hisama F, Wolff R, Becker R, Nasir R, Urion DK, Milunsky JM, Rappaport L, Gusella JF, Walsh CA, Wu BL, Miller DT on behalf of the Autism Consortium Clinical Genetics/DNA Diagnostics Collaboration. Pediatrics. 2010 Apr; 125(4): e727-35.

Cerebellum, language, and cognition in autism and specific language impairment. Hodge SM, Makris N, Kennedy DN, Caviness VS, Howard J, McGrath L, Steele S, Frazier JA, Tager-Flusberg H, Harris GJ. Journal of autism and developmental disorders. 2010 Mar; 40(3): 300-16.

Bipolar Disorder

Current Updates in Pediatric Bipolar Disorder.  Ahn M, Frazier JA.  Directions in Psychiatry 2004; 24:1-20.

Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorder. Frazier JA, Chiu S, Breeze JL, Makris N, Lange N, Kennedy DN, Herbert MR, Bent EK, Koneru VK, Dieterich ME, Hodge SM, Rauch SL, Grant PE, Cohen BM, Seidman LJ, Caviness VS, Biederman J. Am J Psychiatry. 2005 Jul; 162(7): 1256-65.

Neuroimaging studies in pediatric bipolar disorder: a critical review.  Frazier JA, Ahn M, DeJong S, Bent E, Breeze J, Giuliano A.  Harvard Review of Psychiatry. 2005; 13:125-40.

Cortical gray matter differences identified by structural magnetic resonance imaging in pediatric bipolar disorder. Frazier JA, Breeze JL, Makris N, Giuliano AS, Herbert MR, Seidman L, Biederman J, Hodge SM, Dieterich ME, Gerstein ED, Kennedy DN, Rauch SL, Cohen BM, Caviness VS. Bipolar Disord. 2005 Dec; 7(6): 555-69.

Glutamine and glutamate levels in children and adolescents with bipolar disorder: a 4.0-T proton magnetic resonance spectroscopy study of the anterior cingulate cortex. Moore CM, Frazier JA, Glod CA, Breeze JL, Dieterich M, Finn CT, Frederick B, Renshaw PF. Journal of the American Academy of Child and Adolescent Psychiatry. 2007 Apr; 46(4): 524-34.

Anatomic brain magnetic resonance imaging of the basal ganglia in pediatric bipolar disorder. Ahn MS, Breeze JL, Makris N, Kennedy DN, Hodge SM, Herbert MR, Seidman LJ, Biederman J, Caviness VS, Frazier JA. J Affect Disord. 2007 Dec; 104(1-3): 147-54.

White matter abnormalities in children with and at risk for bipolar disorder. Frazier JA, Breeze JL, Papadimitriou G, Kennedy DN, Hodge SM, Moore CM, Howard JD, Rohan MP, Caviness VS, Makris N. Bipolar Disord. 2007 Dec; 9(8): 799-809.

Diagnostic and sex effects on limbic volumes in early-onset bipolar disorder and schizophrenia. Frazier JA, Hodge SM, Breeze JL, Giuliano AJ, Terry JE, Moore CM, Kennedy DN, Lopez-Larson MP, Caviness VS, Seidman LJ, Zablotsky B, Makris N. Schizophr Bull. 2008 Jan; 34(1): 37-46.

The Collaborative Lithium Trials (CoLT): specific aims, methods, and implementation. Findling RL, Frazier JA, Kafantaris V, Kowatch R, McClellan J, Pavuluri M, Sikich L, Hlastala S, Hooper SR, Demeter CA, Bedoya D, Brownstein B, Taylor-Zapata P. Child and adolescent psychiatry and mental health. 2008; 2(1): 21.

Subcortical differences among youths with attention-deficit/hyperactivity disorder compared to those with bipolar disorder with and without attention-deficit/hyperactivity disorder. Lopez-Larson M, Michael ES, Terry JE, Breeze JL, Hodge SM, Tang L, Kennedy DN, Moore CM, Makris N, Caviness VS, Frazier JA. J Child Adolesc Psychopharmacol. 2009 Feb; 19(1): 31-9.

First-dose pharmacokinetics of lithium carbonate in children and adolescents. Findling RL, Landersdorfer CB, Kafantaris V, Pavuluri M, McNamara NK, McClellan J, Frazier JA, Sikich L, Kowatch R, Lingler J, Faber J, Taylor-Zapata P, Jusko WJ. Journal of clinical psychopharmacology. 2010 Aug; 30(4): 404-10.

Age-related changes in the corpus callosum in early-onset bipolar disorder assessed using volumetric and cross-sectional measurements. Lopez-Larson M, Breeze JL, Kennedy DN, Hodge SM, Tang L, Moore C, Giuliano AJ, Makris N, Caviness VS, Frazier JA. Brain imaging and behavior. 2010 Dec; 4(3-4): 220-31.

Atypical Antipsychotics in the Treatment of Early Onset Bipolar Disorder.  Frazier JA, Bregman H, Jackson JA. In Geller B, DelBello M (eds). Treating Child and Adolescent Bipolar Disorder. New York: Guilford Press; 2008.  69-108.

Magnetic Resonance Imaging Studies in Early Onset Bipolar Disorder: An Updated Review.  Terry J, Lopez-Larson M, Frazier JA.  In Dickstein D and Hunt J (eds). Child and Adolescent Psychiatric Clinics of North America. Philadelphia: WB Saunders 2009; 19: 421-39.

Psychosis

Pubertal development and onset of psychosis in childhood onset schizophrenia. Frazier JA, Alaghband-Rad J, Jacobsen L, Lenane MC, Hamburger S, Albus K, Smith A, McKenna K, Rapoport JL. Psychiatry research. 1997 Apr 18; 70(1): 1-7.

Clozapine pharmacokinetics in children and adolescents with childhood-onset schizophrenia. Frazier JA, Cohen LG, Jacobsen L, Grothe D, Flood J, Baldessarini RJ, Piscitelli S, Kim GS, Rapoport JL. Journal of clinical psychopharmacology. 2003 Feb; 23(1): 87-91.

Treatment of early-onset schizophrenia spectrum disorders (TEOSS): demographic and clinical characteristics. Frazier JA, McClellan J, Findling RL, Vitiello B, Anderson R, Zablotsky B, Williams E, McNamara NK, Jackson JA, Ritz L, Hlastala SA, Pierson L, Varley JA, Puglia M, Maloney AE, Ambler D, Hunt-Harrison T, Hamer RM, Noyes N, Lieberman JA, Sikich L. Journal of the American Academy of Child and Adolescent Psychiatry. 2007 Aug; 46(8): 979-88.

Diagnostic and sex effects on limbic volumes in early-onset bipolar disorder and schizophrenia. Frazier JA, Hodge SM, Breeze JL, Giuliano AJ, Terry JE, Moore CM, Kennedy DN, Lopez-Larson MP, Caviness VS, Seidman LJ, Zablotsky B, Makris N. Schizophrenia Bulletin. 2008 Jan; 34(1): 37-46.

Double-blind comparison of first- and second-generation antipsychotics in early-onset schizophrenia and schizo-affective disorder: findings from the treatment of early-onset schizophrenia spectrum disorders (TEOSS) study. Sikich L, Frazier JA, McClellan J, Findling RL, Vitiello B, Ritz L, Ambler D, Puglia M, Maloney AE, Michael E, De Jong S, Slifka K, Noyes N, Hlastala S, Pierson L, McNamara NK, Delporto-Bedoya D, Anderson R, Hamer RM, Lieberman JA. The American Journal of Psychiatry. 2008 Nov; 165(11): 1420-31.

Olanzapine versus placebo in adolescents with schizophrenia: a 6-week, randomized, double-blind, placebo-controlled trial. Kryzhanovskaya L, Schulz SC, McDougle C, Frazier J, Dittmann R, Robertson-Plouch C, Bauer T, Xu W, Wang W, Carlson J, Tohen M. Journal of the American Academy of Child and Adolescent Psychiatry. 2009 Jan; 48(1): 60-70.

Metformin for weight control in pediatric patients on atypical antipsychotic medication. Shin L, Bregman H, Breeze JL, Noyes N, Frazier JA. Journal of child and adolescent psychopharmacology. 2009 Jun; 19(3): 275-9.

Neurocognition in early-onset schizophrenia and schizoaffective disorders. Hooper SR, Giuliano AJ, Youngstrom EA, Breiger D, Sikich L, Frazier JA, Findling RL, McClellan J, Hamer RM, Vitiello B, Lieberman JA. Journal of the American Academy of Child and Adolescent Psychiatry. 2010 Jan; 49(1): 52-60.

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