One of the defining features of living organisms is their astonishing complexity. Even seemingly simple single cell organisms such as microbes display exceedingly complex behaviors, determined by intricate molecular networks in which large numbers of molecular components, pathways and chemical reactions act together. These behaviors have fascinated scientists for decades and include development, response to pathogenic and environmental insults and interactions with other organisms. Understanding how complexity of living systems arises and coordinates cellular function and pathologies continues to be one of the principal goals of biomedical research today.
The Department of Systems Biology (DSB) studies how biological complexity can be derived and understood from the interplay between individual components and processes that combine to make up living organisms.
The department brings together an enthusiastic and highly collaborative group of scientists that employ an array of experimental and computational approaches to study a variety of biological systems. Research in the program ranges from quantitative studies of properties of single cells to analyses of complex phenotypes of animals, and leverages the latest technological developments in the areas of molecular biology, genomics, high-content imaging, quantitative modeling, computer science and bioinformatics. The commonality of all research in the program is the integration of high-throughput experimentation and quantitative data analyses to study how biological systems behave, respond, adapt and evolve. Disease states are increasingly considered to be caused not by a singular biochemical alteration, but instead are viewed as the result of wider disruptions of the complex interplay between the many molecular components and processes that make up the human body. Researchers in the program aim to unravel how systems go awry in a variety of pathologies and how systems can be perturbed to mitigate disease.
Latest News |
Welcome to Qi Liu, a new postdoc in the Youk Lab! |
Learn more about Qi here. |
Mariana Noto Guillen, a PhD candidate in Amir Mitchell’s lab, highlights her work and work from the lab to understand how non-antibiotic drugs kill bacteria in this article in The Conversation. |
Drugs that aren’t antibiotics can also kill bacteria − new method pinpoints how |
“Our findings open multiple opportunities for researchers to study how nonantibiotic drugs work differently from standard antibiotics. Our method of mapping and testing drugs also has the potential to address a critical bottleneck in developing antibiotics.” |
Welcome New Rotation Students!Yi-Hsuan Hsieh (Watson Lab)Joseph Paquette (Lee Lab)Hannah Rogers (Brewster Lab)John Solitro (Walhout Lab) |
Emma Watson has been awarded a Young Investigator Grant from The Breast Cancer Alliance. Congratulations Emma! |
Read more about research in the Watson Lab here. |
Welcome to Nicholas Genovese who recently joined the Youk Lab as their newest Research Associate! |
Read more about Nicholas here |
Welcome Back to: |
Megan Honeywell - current position Post doc in the Lee Lab |
Serkan Sayin - current position Post doc in the Mitchell Lab |
Sunil Guharajan - current position Research Associate in the Brewster Lab |
Welcome to rotation students, Naoto Hikawa (Walhout Lab) and Run Sun (Dekker Lab)!Jan, 2024 |
Mike Lee has been named the first Vice Chair of the Department of Systems BiologyNov, 2023 |
The DSB congratulates Nick Harper who was awarded a Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship from the National Cancer Institute to study mechanisms of cell death upon transcriptional inhibition. Read more about Nick and his research here.Sept, 2023 |
The Department of Systems Biology Welcomes Ann Xu a new Research Technician in the Youk LabAug, 2023 |
Elizabeth Shank recently contributed to this Nature Medicine News article about antibiotic resistance. Read the full article here. |
Congratulations to Job Dekker on his induction into the National Academy of Sciences on April 28, 2023. |
The Department of Systems Biology Welcomes new Postdoc Arun Kumar to the Walhout LabMay, 2023 |
Listen as Job Dekker talks about the 3D genome organization of Dinoflagellates and more. |
The DSB Welcomes Our New Rotation StudentsHanbing Cao (Dekker Lab)Christopher Jahns (Shank Lab)Arshia Kaur (Shank Lab)Claudia Perez (Watson Lab)Alejandra Rivera Nieves (Watson Lab) |
Congratulations to Job Dekker on his induction into the National Academy of Medicine on October 14, 2022. Please watch the short video below to see him receive this honor! |
Two new Research Technicians have joined The Watson Lab. Please welcome Rayna Magesh and Abdulrazak Frederick to the DSB. Click here to learn more about them. |
The Department of Systems Biology Welcomes Emma Watson as the Newest Faculty Member |
Marian Walhout, PhD, was Awarded the Chancellor's Medal for Distinguished Scholarship |
Congratulations to Elizabeth Shank |
Congratulations to Job Dekker |
Congratulations to Hyun Youk |
The Mitchell Lab Welcomes Jacob Furman as an InternJuly 25, 2022 |
The Department of Systems Biology Welcomes Alyxandra Starbard to the Walhout lab as a Research Lab TechJune, 2022 |
The Department of Systems Biology Welcomes Elodie Killick to the Brewster Lab as an Undergraduate Intern |
Congratulations to Amir Mitchell, PhD on Receiving a new RO1 Award:“Mechanisms underlying bacterial sensitivity to host-targeted drugs” from the NIH National Institute Of Allergy And Infectious Diseases.June, 2022 |
The Department of Systems Biology Welcomes Nezar Abdennur, PhDJune, 2022 |
The Department of Systems Biology Welcomes Juliet Bolduc to the Walhout lab as an Undergraduate InternMay, 2022 |
The Department of Systems Biology Welcomes Daniel Richards to the Walhout Lab as a Research AssociateMay, 2022 |
The Department of Systems Biology Welcomes a Scientific Writer, Caryn NavarroMay, 2022 |
Job Dekker elected to National Academy of Sciences |
More News |