Welcome to the Program in Systems Biology

Our program aims to explore the mechanisms and principles of biological complexity. This is an exciting time for systems biology, with rapid technological advances in many fields including genomics, computational biology, imaging, mass spectroscopy and bioinformatics. Research in the program develops and leverages technological breakthroughs in these areas to explore the biology of complex systems. Today’s scientific research in general, and systems biology in particular, is increasingly multi-disciplinary. Therefore, we aim to create an intellectually diverse environment where combining different fields is encouraged and where students, post-doctoral fellows and faculty from different backgrounds work together in a collegial and interactive atmosphere.

Please browse through our website to learn more about our ongoing research, find recent publications and news items, upcoming speakers in our seminar series, or visit us at the UMass, Worcester campus.

A.J. Marian Walhout, Ph.D. & Job Dekker, Ph.D., Co-Directors

Featured Publications

Bacterial Metabolism Affects the C. elegans Response to Cancer Chemotherapeutics. García-González AP, Ritter AD, Shrestha S, Andersen EC, Yilmaz LS, Walhout AJM. Cell. 2017 Apr 20;169(3):431-441.

Effect of transcription factor resource sharing on gene expression noise. Das D, Dey S, Brewster RC, Choubey S. PLoS Comput. Biol. 2017 Apr 17;13(4):e1005491.

A gene-centered C. elegans protein-DNA interaction network provides a framework for functional predictions. Fuxman Bass JI, Pons C, Kozlowski L, Reece-Hoyes JS, Shrestha S, Holdorf AD, Mori A, Myers CL, Walhout AJ. Mol. Syst. Biol. 2016 Oct 24;12(10):884.

Structural organization of the inactive X chromosome in the mouse. Giorgetti L, Lajoie BR, Carter AC, Attia M, Zhan Y, Xu J, Chen CJ, Kaplan N, Chang HY, Heard E, Dekker J. Nature. 2016 Jul 28;535(7613):575-9.

Metabolic network rewiring of propionate flux compensates vitamin B12 deficiency in C. elegans. Watson E, Olin-Sandoval V, Hoy MJ, Li C, Louisse T, Yao V, Mori A, Holdorf AD, Troyanskaya OG, Ralser M, Walhout AJM. eLife. 2016 Jul 6;5. pii: e17670.

Oscillatory stress stimulation uncovers an Achilles' heel of the yeast MAPK signaling network. Mitchell A, Wei P, Lim WA. Science. 2015 Dec 11;350(6266):1379-83.

Condensin-driven remodeling of X chromosome topology during dosage compensation. Crane E, Bian Q, McCord RP, Lajoie BR, Wheeler BS, Ralston EJ, Uzawa S, Dekker J, Meyer BJ. Nature. 2015 Jul 9;523(7559):240-4.

The transcription factor titration effect dictates level of gene expression. Brewster RC, Weinert FM, Garcia HG, Song D, Rydenfelt M, Phillips R. Cell. 2014 Mar 13;156(6):1312-23.

Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Lee MJ, Ye AS, Gardino AK, Heijink AM, Sorger PK, MacBeath G, Yaffe MB. Cell. 2012 May 11;149(4):780-94.