Section: Research

John Sullivan, M.D.

Academic Role: Professor

Faculty Appointment(s) In:
   Pediatrics

Other Affiliation(s):
   Center for AIDS Research
   Center for Infectious Disease and Vaccine Research
   Clinical and Population Health Research
   Interdisciplinary Graduate Program
   Molecular Genetics and Microbiology
   Program in Immunology and Virology
   Program in Molecular Medicine

Epstein-Barr Virus [EBV] and Human Immunodeficiency Virus [HIV]

Research in this laboratory is aimed at understanding the pathogenesis of chronic infection with Epstein-Barr Virus [EBV] and Human Immunodeficiency Virus [HIV]. Studies of EBV are focused on the nature of the immune response which controls but does not eradicate viral replication and the nature of the immune defect which results in the X-linked lymphoproliferative syndrome.  Studies of HIV are focused on the elucidation and characterization of HIV gene mutations which result in infections associated with long term control of viral replication and/or lack of disease progression.

Experimental therapeutic and preventative vaccine approaches are also being studied. These include combination antiretroviral agents to interrupt viral replication and recombinant vector or live attenuated vaccines to prevent HIV-1 infection. Of particular interest is the development of therapeutics and vaccine regimens which can be used in the developing world to interrupt maternal to child transmission.

Office: S1-859
Phone: 508-856-1572
Fax: 508-856-5004
E-mail: John.Sullivan@umassmed.edu
Keywords: Immunology, Viral Infections and Immunity, Clinical Research, Infectious Disease, HIV/AIDS

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