Selected Publications 2008 - 2014

Distinct functions for IFT140 and IFT20 in opsin transport.

Crouse JA, Lopes VS, Sanagustin JT, Keady BT, Williams DS, Pazour GJ.  Cytoskeleton (Hoboken). 2014 May;71(5):302-10. doi: 10.1002/cm.21173. Epub 2014 Mar 25.  PMID: 24619649 (Paper)

IFT27 Links the BBSome to IFT for Maintenance of the Ciliary Signaling Compartment.

Eguether T, San Agustin JT, Keady BT, Jonassen JA, Liang Y, Francis R, Tobita K, Johnson CA, Abdelhamed ZA, Lo CW, Pazour GJ. Dev Cell. 2014 Nov 10;31(3):279-90. doi: 10.1016/j.devcel.2014.09.011. Epub 2014 Oct 30. PMID: 25446516 (Paper)

CPEB-regulation of TAK1 Synthesis Mediates Cytokine Production and the Inflammatory Immune Response.

Ivshina M, Alexandrov IM, Vertii A, Doxsey S, Richter JD.  Mol Cell Biol. 2014 Dec 1. pii: MCB.00800-14. PMID: 25452303 (Paper)

Direct interactions promote eviction of the Sir3 heterochromatin protein by the SWI/SNF chromatin remodeling enzyme.

Manning BJ, Peterson CL.Proc Natl Acad Sci U S A. 2014 Dec 1. pii: 201420096.  PMID: 25453095 (Paper)

The conserved misshapen-warts-yorkie pathway acts in enteroblasts to regulate intestinal stem cells in Drosophila.

Li Q, Li S, Mana-Capelli S, Roth Flach RJ, Danai LV, Amcheslavsky A, Nie Y, Kaneko S, Yao X, Chen X, Cotton JL, Mao J, McCollum D, Jiang J, Czech MP, Xu L, Ip YT. Dev Cell. 2014 Nov 10;31(3):291-304. doi: 10.1016/j.devcel.2014.09.012. Epub 2014 Nov 10. (Paper)

A Negative Feedback Loop of Transcription Factors Specifies Alternative Dendritic Cell Chromatin States.

Bornstein C, Winter D, Barnett-Itzhaki Z, David E, Kadri S, Garber M, Amit I.  Mol Cell. 2014 Nov 20. pii: S1097-2765(14)00798-9. doi: 10.1016/j.molcel.2014.10.014. (Paper)

Control of adipose tissue expandability in response to high fat diet by the insulin-like growth factor-binding protein-4.

Gealekman O, Gurav K, Chouinard M, Straubhaar J, Thompson M, Malkani S, Hartigan C, Corvera S. J Biol Chem. 2014 Jun 27;289(26):18327-38. doi: 10.1074/jbc.M113.545798. Epub 2014 Apr 28.PMID: 24778188 (Paper)

miR-14 Regulates Autophagy during Developmental Cell Death by Targeting ip3-kinase 2.
Nelson C, Ambros V, Baehrecke EH.

Nelson C, Ambros V, Baehrecke EH. Mol Cell. 2014 Oct 8. pii: S1097-2765(14)00718-7. doi: 10.1016/j.molcel.2014.09.011. [Epub ahead of print] PMID: 25306920 (Paper)

NrasG12D oncoprotein inhibits apoptosis of preleukemic cells expressing Cbf?-SMMHC via activation of MEK/ERK axis.

Xue L, Pulikkan JA, Valk PJ, Castilla LH.  Blood. 2014 Jul 17;124(3):426-36. doi: 10.1182/blood-2013-12-541730. Epub 2014 Jun 3. PMID: 24894773 (Paper)

Enteroendocrine Cells Support Intestinal Stem-Cell-Mediated Homeostasis in Drosophila.

Amcheslavsky A, Song W, Li Q, Nie Y, Bragatto I, Ferrandon D, Perrimon N, Ip YT.  Cell Rep. 2014 Sep 24. pii: S2211-1247(14)00728-1. doi: 10.1016/j.celrep.2014.08.052. (Paper)

A Unique Set of Centrosome Proteins Requires Pericentrin for Spindle-Pole Localization and Spindle Orientation.

Chun-Ting Chen, Heidi Hehnly, Qing Yu, Debby Farkas, Guoqiang Zheng, Sambra D. Redick, Hui-Fang Hung, Rajeev Samtani, Agata Jurczyk, Schahram Akbarian, Carol Wise, Andrew Jackson, Michael Bober, Yin Guo, Cecilia Lo, and Stephen Doxsey (Paper)

A separable domain of the p150 subunit of human chromatin assembly factor-1 promotes protein and chromosome associations with nucleoli.

Smith CL, Matheson TD, Sun X, Trombly DJ, Campeau E, Han X, Yates JR 3rd, and Kaufman PD (Paper) 

IL-1 Signaling in Obesity-Induced Hepatic Lipogenesis and Steatosis.

Negrin KA, Roth Flach RJ, DiStefano MT, Matevossian A, Friedline RH, Jung D, Kim JK, Czech MP.  PLoS One. 2014 Sep 12;9(9):e107265. doi: 10.1371/journal.pone.0107265. eCollection 2014.  PMID: 25216251 (Paper)

A therapeutically targetable mechanism of BCR-ABL-independent imatinib resistance in chronic myeloid leukemia.

Ma L, Shan Y, Bai R, Xue L, Eide CA, Ou J, Zhu LJ, Hutchinson L, Cerny J, Khoury HJ, Sheng Z, Druker BJ, Li S, Green MR.  Sci Transl Med. 2014 Sep 3;6(252):252ra121. doi: 10.1126/scitranslmed.3009073.  PMID: 25186176 (Paper)

Solution-state conformation and stoichiometry of yeast Sir3 heterochromatin fibres.

Swygert SG, Manning BJ, Senapati S, Kaur P, Lindsay S, Demeler B, Peterson CL.  Nat Commun. 2014 Aug 28;5:4751. doi: 10.1038/ncomms5751. PMID: 25163529 (Paper)

Gene expression profiling identifies the zinc-finger protein Charlatan as a regulator of intestinal stem cells in Drosophila.

Amcheslavsky A, Nie Y, Li Q, He F, Tsuda L, Markstein M, Ip YT. Development. 2014 Jul;141(13):2621-32. doi: 10.1242/dev.106237. PMID: 24961799 (Paper)

The HP1 homolog rhino anchors a nuclear complex that suppresses piRNA precursor splicing.

Zhang Z, Wang J, Schultz N, Zhang F, Parhad SS, Tu S, Vreven T, Zamore PD, Weng Z, Theurkauf WE.  Cell. 2014 Jun 5;157 (Paper)

Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis.

Ward J, Kanchagar C, Veksler-Lublinsky I, Lee RC, McGill MR, Jaeschke H, Curry SC, Ambros VR.  Proc Natl Acad Sci U S A. 2014 Aug 4. pii: 201412608. [Epub ahead of print]  PMID: 25092309 (Paper)

The Embryonic mir-35 Family of MicroRNAs Promotes Multiple Aspects of Fecundity in C. elegans.

McJunkin K, Ambros V.  G3 (Bethesda). 2014 Jul 21. pii: g3.114.011973. doi: 10.1534/g3.114.011973. [Epub ahead of print]  PMID: 25053708 (Paper)

The PPARα-FGF21 Hormone Axis Contributes to Metabolic Regulation by the Hepatic JNK Signaling Pathway.

Vernia S, Cavanagh-Kyros J, Garcia-Haro L, Sabio G, Barrett T, Jung DY, Kim JK, Xu J, Shulha HP, Garber M, Gao G, Davis RJ.  Cell Metab. 2014 Jul 15. (Paper)

Rictor/mTORC2 Loss in the Myf5 Lineage Reprograms Brown Fat Metabolism and Protects Mice against Obesity and Metabolic Disease.

Hung CM, Calejman CM, Sanchez-Gurmaches J, Li H, Clish CB, Hettmer S, Wagers AJ, Guertin DA. (Paper)

A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection.

Gammon DB, Duraffour S, Rozelle DK, Hehnly H, Sharma R, Sparks ME, West CC, Chen Y, Moresco JJ, Andrei G, Connor JC, Conte D, Gundersen-Rindal DE, Marshall WL, Yates J, Silverman N, Mello CC.   (Paper)

Gene expression profiling identifies the zinc-finger protein Charlatan as a regulator of intestinal stem cells in Drosophila.

Amcheslavsky A, Nie Y, Li Q, He F, Tsuda L, Markstein M, Ip YT. (Paper)

Adipocytes arise from multiple lineages that are heterogeneously and dynamically distributed.

Sanchez-Gurmaches J, Guertin DA. Nat Commun. 2014 Jun 19;5:4099. doi: 10.1038/ncomms5099. PMID: 24942009 (Paper)

Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation.

Amano SU, Cohen JL, Vangala P, Tencerova M, Nicoloro SM, Yawe JC, Shen Y, Czech MP, Aouadi M.Cell Metab. 2014 Jan 7;19(1):162-71. doi: 10.1016/j.cmet.2013.11.017. Epub 2013 Dec 26. PMID: 24374218(Paper)

Role of the mixed-lineage protein kinase pathway in the metabolic stress response to obesity.

Kant S, Barrett T, Vertii A, Noh YH, Jung DY, Kim JK, Davis RJ. Cell Rep. 2013 Aug 29;4(4):681-8. doi: 10.1016/j.celrep.2013.07.019. Epub 2013 Aug 15. PMID: 23954791 [PubMed](Paper)

Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells.

Kearns NA, Genga RM, Enuameh MS, Garber M, Wolfe SA, Maehr R. Development. 2014 Jan;141(1):219-23. doi: 10.1242/dev.103341. PMID: 24346702 [PubMed - indexed for MEDLINE] (Paper)

EBV Latent Membrane Protein 1 genetic variability in peripheral blood B cells and oropharyngeal fluids.

Renzette N, Somasundaran M, Brewster F, Coderre J, Weiss ER, McManus M, Greenough T, Tabak B, Garber M, Kowalik TF, Luzuriaga K. J Virol. 2014 Jan 15. [Epub ahead of print] PMID: 24429365 (Paper)

Evolutionary dynamics and tissue specificity of human long noncoding RNAs in six mammals.

Washietl S, Kellis M, Garber M.Genome Res. 2014 Jan 15. [Epub ahead of print] PMID:24429298 (Paper)

Distinct functions for IFT140 and IFT20 in opsin transport.

Crouse JA, Lopes VS, Sanagustin JT, Keady BT, Williams DS, Pazour GJ.  Cytoskeleton (Hoboken). 2014 Mar 12. doi: 10.1002/cm.21173. [Epub ahead of print] PMID: 24619649 [PubMed - as supplied by publisher] (Paper)

A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype.

Serra RW, Fang M, Park SM, Hutchinson L, Green MR.  Elife. 2014 Mar 12;3:e02313. doi: 10.7554/eLife.02313.  PMID: 24623306 [PubMed] (Paper)

Arf4 is required for Mammalian development but dispensable for ciliary assembly.

Follit JA, San Agustin JT, Jonassen JA, Huang T, Rivera-Perez JA, Tremblay KD, Pazour GJ.   PLoS Genet. 2014 Feb 20;10(2):e1004170. doi: 10.1371/journal.pgen.1004170. eCollection 2014 Feb. PMID: 24586199 (Paper)

EBV Latent Membrane Protein 1 genetic variability in peripheral blood B cells and oropharyngeal fluids.

Renzette N, Somasundaran M, Brewster F, Coderre J, Weiss ER, McManus M, Greenough T, Tabak B, Garber M, Kowalik TF, Luzuriaga K. J Virol. 2014 Jan 15. (Paper)

Interspecies systems biology uncovers metabolites affecting C. elegans gene expression and life history traits.

Watson E, Macneil LT, Ritter AD, Yilmaz LS, Rosebrock AP, Caudy AA, Walhout AJ.  Cell. 2014 Feb 13;156(4):759-70. doi: 10.1016/j.cell.2014.01.047. PMID: 24529378 (Paper)

Rab11 Endosomes Contribute to Mitotic Spindle Organization and Orientation.

Hehnly H, Doxsey S. Dev Cell. 2014 Feb 18. pii: S1534-5807(14)00037-9. doi: 10.1016/j.devcel.2014.01.014. PMID: 24561039 (Paper)

Argonautes promote male fertility and provide a paternal memory of germline gene expression in C. elegans.

Conine CC, Moresco JJ, Gu W, Shirayama M, Conte D Jr, Yates JR 3rd, Mello CC.
Cell. 2013 Dec 19;155(7):1532-44. doi: 10.1016/j.cell.2013.11.032. PMID: 24360276 (Paper)

Genetic and acute CPEB1 depletion ameliorate fragile X pathophysiology.

Udagawa T, Farny NG, Jakovcevski M, Kaphzan H, Alarcon JM, Anilkumar S, Ivshina M, Hurt JA, Nagaoka K, Nalavadi VC, Lorenz LJ, Bassell GJ, Akbarian S, Chattarji S, Klann E, Richter JD. Nat Med. 2013 Nov;19(11):1473-7. doi: 10.1038/nm.3353. Epub 2013 Oct 20.
PMID: 24141422 [PubMed - indexed for MEDLINE] (Paper)

Gudu, an Armadillo repeat-containing protein, is required for spermatogenesis in Drosophila.

Cheng W, Ip YT, Xu Z.  Gene. 2013 Dec 1;531(2):294-300. doi: 10.1016/j.gene.2013.08.080. Epub 2013 Sep 17. PMID: 24055424 [PubMed - indexed for MEDLINE] (Paper)

Diet-induced obesity mediated by the JNK/DIO2 signal transduction pathway.

Vernia S, Cavanagh-Kyros J, Barrett T, Jung DY, Kim JK, Davis RJ.  Genes Dev. 2013 Nov 1;27(21):2345-55. doi: 10.1101/gad.223800.113. PMID: 24186979 [PubMed - indexed for MEDLINE] (Paper)

Argonautes Promote Male Fertility and Provide a Paternal Memory of Germline Gene Expression in C. elegans.

Conine CC, Moresco JJ, Gu W, Shirayama M, Conte D Jr, Yates JR 3rd, Mello CC. Cell. 2013 Dec 19;155(7):1532-44. doi: 10.1016/j.cell.2013.11.032. PMID: 24360276 [PubMed - in process] (Paper)

The C. elegans CSR-1 Argonaute Pathway Counteracts Epigenetic Silencing to Promote Germline Gene Expression.

Seth M, Shirayama M, Gu W, Ishidate T, Conte D Jr, Mello CC. Dev Cell. 2013 Dec 18. pii: S1534-5807(13)00695-3. doi: 10.1016/j.devcel.2013.11.014. [Epub ahead of print] (Paper)

Using networks to measure similarity between genes: association index selection.

Fuxman Bass JI, Diallo A, Nelson J, Soto JM, Myers CL, Walhout AJ. Nat Methods. 2013 Nov 26;10(12):1169-76. doi: 10.1038/nmeth.2728. PMID: 24296474 Paper

Hdac6 regulates Tip60-p400 function in stem cells

Chen PB, Hung JH, Hickman TL, Coles AH, Carey JF, Weng Z, Chu F, Fazzio TG.   Elife. 2013 Dec 4;2(0):e01557. doi: 10.7554/eLife.01557. PMID: 24302573 Paper

Absence of Detectable HIV-1 Viremia after Treatment Cessation in an Infant.

Persaud D, Gay H, Ziemniak C, Chen YH, Piatak M, Chun TW, Strain M, Richman D, Luzuriaga K.N Engl J Med. 2013 Oct 23.Paper

Structural basis for membrane recruitment and allosteric activation of cytohesin family Arf GTPase exchange factors.

Malaby AW, van den Berg B, Lambright DG. Proc Natl Acad Sci U S A. 2013 Aug 12. [Epub ahead of print] PMID: 23940353 [PubMed - as supplied by publisher] Paper

Chemical screening identifies filastatin, a small molecule inhibitor of Candida albicans adhesion, morphogenesis, and pathogenesis.

Fazly A, Jain C, Dehner AC, Issi L, Lilly EA, Ali A, Cao H, Fidel PL, P Rao R, Kaufman PD. Chemical screening identifies filastatin, a small molecule inhibitor of Candida albicans adhesion, morphogenesis, and pathogenesis. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):13594-9. Paper

Generation of organized anterior foregut epithelia from pluripotent stem cells using small molecules

Kearns NA, Genga RM, Ziller M, Kapinas K, Peters H, Brehm MA, Meissner A, Maehr R. Stem Cell Res. 2013 Jun 29;11(3):1003-1012. doi: 10.1016/j.scr.2013.06.007. [Epub ahead of print] Paper

Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice.

Aouadi M, Tencerova M, Vangala P, Yawe JC, Nicoloro SM, Amano SU, Cohen JL, Czech MP.   Proc Natl Acad Sci U S A. 2013 Apr 29. Paper

A histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzyme.

Watanabe S, Radman-Livaja M, Rando OJ, Peterson CL. Science. 2013 Apr 12;340(6129):195-9. Paper

CapSeq and CIP-TAP identify Pol II start sites and reveal capped small RNAs as C. elegans piRNA precursors.

Gu W, Lee HC, Chaves D, Youngman EM, Pazour GJ, Conte D Jr, Mello CC. Cell. 2012 Dec 21;151(7):1488-500. doi: 10.1016/j.cell.2012.11.023. PMID: 23260138 [PubMed - indexed for MEDLINE] Paper

Efficiency of bridging-sheet recruitment explains HIV-1 R5 envelope glycoprotein sensitivity to soluble CD4 and macrophage tropism.

O'Connell O, Repik A, Reeves JD, Gonzalez-Perez MP, Quitadamo B, Anton ED, Duenas-Decamp M, Peters P, Lin R, Zolla-Pazner S, Corti D, Wallace A, Wang S, Kong XP, Lu S, Clapham PR. J Virol. 2013 Jan;87(1):187-98. doi: 10.1128/JVI.01834-12. Epub 2012 Oct 10. PMID: 23055568 [PubMed - indexed for MEDLINE] Paper

HERV-H RNA is abundant in human embryonic stem cells and a precise marker for pluripotency.

Santoni FA, Guerra J, Luban J. Retrovirology. 2012 Dec 20;9(1):111. [Epub ahead of print] Paper

A Synthetic Interaction Screen Identifies Factors Selectively Required for Proliferation and TERT Transcription in p53-Deficient Human Cancer Cells.

Xie L, Gazin C, Park SM, Zhu LJ, Debily MA, Kittler EL, Zapp ML, Lapointe D, Gobeil S, Virbasius CM, Green MR. PLoS Genet. 2012 Dec; Epub 2012 Dec 20. Paper

β3-adrenergic receptor stimulation induces E-selectin-mediated adipose tissue inflammation.

Roth Flach RJ, Matevossian A, Akie TE, Negrin KA, Paul MT, Czech MP. J Biol Chem. 2012 Dec 12 Paper

Translational control of mitochondrial energy production mediates neuron morphogenesis.

Oruganty-Das A, Ng T, Udagawa T, Goh EL, Richter JD. Cell Metab. 2012 Dec 12 Paper

JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation.

Han MS, Jung DY, Morel C, Lakhani SA, Kim JK, Flavell RA, Davis RJ. Science. 2012 Dec 6 Paper

Specific miRNA Stabilization by Gld2-Catalyzed Monoadenylation.

D'Ambrogio A, Gu W, Udagawa T, Mello CC, Richter JD. Cell Rep. 2012 Nov 28. doi:pii: S2211-1247. Paper

Identification of Map4k4 as a novel suppressor of skeletal muscle differentiation.

Wang M, Amano SU, Roth Flach RJ, Chawla A, Aouadi M, Czech MP. Mol Cell Biol. 2012 Dec 3. [Epub ahead of print] Paper

An MBoC Favorite: Role of GTP hydrolysis in microtubule dynamics: information from a slowly hydrolyzable analogue, GMPCPP.

Chen CT, Doxsey SJ. Mol Biol Cell. 2012 Oct;23(19):3775. Paper

PTEN loss in the Myf5 lineage redistributes body fat and reveals subsets of white adipocytes that arise from Myf5 precursors.

Sanchez-Gurmaches J, Hung CM, Sparks CA, Tang Y, Li H, Guertin DA. Cell Metab. 2012 Sep 5;16(3):348-62. Paper

Transcription factor ATF5 is required for terminal differentiation and survival of olfactory sensory neurons.

Wang SZ, Ou J, Zhu LJ, Green MR. Proc Natl Acad Sci U S A. 2012 Oct 22. Paper

An Unusual Two Step Control of CPEB Destruction by Pin1.

Nechama M, Lin CL, Richter JD.  Mol Cell Biol. 2012 Oct 22.  Paper  

JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate.

Hübner A, Mulholland DJ, Standen CL, Karasarides M, Cavanagh-Kyros J, Barrett T, Chi H, Greiner DL, Tournier C, Sawyers CL, Flavell RA, Wu H, Davis RJ. Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12046-51. Paper



Functional cooperation of the proapoptotic Bcl2 family proteins Bmf and Bim in vivo.

Hübner A, Cavanagh-Kyros J, Rincon M, Flavell RA, Davis RJ.  Mol Cell Biol. 2010 Jan;30(1):98-105.

The Argonaute CSR-1 and its 22G-RNA cofactors are required for holocentric chromosome segregation

Claycomb JM, Batista PJ, Pang KM, Gu W, Vasale JJ, van Wolfswinkel JC, Chaves DA, Shirayama M, Mitani S, Ketting RF, Conte D Jr, Mello CC.  Cell. 2009 Oct 2;139(1):123-34.

Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline.

Gu W, Shirayama M, Conte D Jr, Vasale J, Batista PJ, Claycomb JM, Moresco JJ, Youngman EM, Keys J, Stoltz MJ, Chen CC, Chaves DA, Duan S, Kasschau KD, Fahlgren N, Yates JR 3rd, Mitani S, Carrington JC, Mello CC.  Mol Cell. 2009 Oct 23;36(2):231-44. Epub 2009 Oct 1.

Recombinational repair within heterochromatin requires ATP-dependent chromatin remodeling.

Sinha M, Watanabe S, Johnson A, Moazed D, Peterson CL.  Cell. 2009 Sep 18;138(6):1109-21.



Nutrient stress activates inflammation and reduces glucose metabolism by suppressing AMP-activated protein kinase in the heart.

Ko HJ, Zhang Z, Jung DY, Jun JY, Ma Z, Jones KE, Chan SY, Kim JK. Diabetes. 2009 Nov;58(11):2536-46. Epub 2009 Aug 18.

Signal transduction cross talk mediated by Jun N-terminal kinase-interacting protein and insulin receptor substrate scaffold protein complexes.

Standen CL, Kennedy NJ, Flavell RA, Davis RJ. Mol Cell Biol. 2009 Sep;29(17):4831-40. Epub 2009 Jun 29.

Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis.

Morel C, Carlson SM, White FM, Davis RJ.  Mol Cell Biol. 2009 Jul;29(14):3845-52. Epub 2009 May 11.

Mechanisms that regulate localization of a DNA double-strand break to the nuclear periphery.

Oza P, Jaspersen SL, Miele A, Dekker J, Peterson CL.Genes Dev. 2009 Apr 15;23(8):912-27.

A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors. 

Grove CA, De Masi F, Barrasa MI, Newburger DE, Alkema MJ, Bulyk ML, Walhout AJ. Cell. 2009 Jul 23;138(2):314-27.

Induction of hepatitis by JNK-mediated expression of TNF-alpha.

Das M, Sabio G, Jiang F, Rincón M, Flavell RA, Davis RJ. Cell. 2009 Jan 23;136(2):249-60.

Transmembrane passage of hydrophobic compounds through a protein channel wall.

Hearn EM, Patel DR, Lepore BW, Indic M, van den Berg B.  Nature. 2009 Mar 19;458(7236):367-70. Epub 2009 Feb 1.

Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation.

Aouadi M, Tesz GJ, Nicoloro SM, Wang M, Chouinard M, Soto E, Ostroff GR, Czech MP. Nature. 2009 Apr 30;458(7242):1180-4.

Three distinct condensin complexes control C. elegans chromosome dynamics.

Csankovszki G, Collette K, Spahl K, Carey J, Snyder M, Petty E, Patel U, Tabuchi T, Liu H, McLeod I, Thompson J, Sarkesik A, Yates J, Meyer BJ, Hagstrom K. Curr Biol. 2009 Jan 13;19(1):9-19.; PM ID: 19119011 [PubMed - in process]

An essential role for the RNA-binding protein Smaug during the Drosophila maternal-to-zygotic transition.

Benoit B, He CH, Zhang F, Votruba SM, Tadros W, Westwood JT, Smibert CA, Lipshitz HD, Theurkauf WE.  Development. 2009 Mar;136(6):923-32. PMID: 19234062 [PubMed - in process]

Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint. 

Sivaram MV, Wadzinski TL, Redick SD, Manna T, Doxsey SJ.  EMBO J. 2009 Feb 19. [Epub ahead of print] PMID: 19229290 [PubMed - as supplied by publisher]

A last-minute rescue of trapped chromatin.

Chen CT, Doxsey S.Cell. 2009 Feb 6;136(3):397-9. PMID: 19203574 [PubMed - indexed for MEDLINE]

mirWIP: microRNA target prediction based on microRNA-containing ribonucleoprotein-enriched transcripts.

Hammell M, Long D, Zhang L, Lee A, Carmack CS, Han M, Ding Y, Ambros V.Nat Methods. 2008 Sep;5(9):813-9.PMID: 19160516 [PubMed - indexed for MEDLINE]

Chapter 5 targeting proteins to the ciliary membrane.

Pazour GJ, Bloodgood RA.  Curr Top Dev Biol. 2008;85:115-49.PMID: 19147004 [PubMed - in process]

The ESCRT pathway and HIV-1 budding. 

Usami Y, Popov S, Popova E, Inoue M, Weissenhorn W, G Göttlinger H. 
Biochem Soc Trans. 2009 Feb;37(Pt 1):181-4.PMID: 19143627 [PubMed - indexed for MEDLINE]

CPEB regulation of human cellular senescence, energy metabolism, and p53 mRNA translation.

Burns DM, Richter JD.Genes Dev. 2008 Dec 15;22(24):3449-60.PMID: 19141477 [PubMed - indexed for MEDLINE]

Making synaptic plasticity and memory last: mechanisms of translational regulation.

Richter JD, Klann E.  Genes Dev. 2009 Jan 1;23(1):1-11. Review.PMID: 19136621 [PubMed - indexed for MEDLINE]

Determinants flanking the CD4 binding loop modulate macrophage-tropism of HIV-1 R5 envelopes.

Duenas-Decamp MJ, Peters P, Burton D, Clapham PR.  J Virol. 2009 Jan 7. [Epub ahead of print] PMID: 19129457 [PubMed - as supplied by publisher]

Tissue damage-induced intestinal stem cell division in Drosophila.

Amcheslavsky A, Jiang J, Ip YT.Cell Stem Cell. 2009 Jan 9;4(1):49-61.PMID: 19128792 [PubMed - indexed for MEDLINE]

The Golgin GMAP210/TRIP11 anchors IFT20 to the Golgi complex.

Follit JA, San Agustin JT, Xu F, Jonassen JA, Samtani R, Lo CW, Pazour GJ.  PLoS Genet. 2008 Dec;4(12):e1000315. Epub 2008 Dec 26.PMID: 19112494 [PubMed - indexed for MEDLINE]

Plugging gp120s cavity.

Repik A, Clapham PR.  Structure. 2008 Nov 12;16(11):1603-4. PMID: 19000812 [PubMed - indexed for MEDLINE]

Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease.

Jonassen JA, San Agustin J, Follit JA, Pazour GJ.  J Cell Biol. 2008 Nov 3;183(3):377-84.PMID: 18981227 [PubMed - indexed for MEDLINE]

Sorting of EGF and transferrin at the plasma membrane and by cargo-specific signaling to EEA1-enriched endosomes.

Leonard D, Hayakawa A, Lawe D, Lambright D, Bellve KD, Standley C, Lifshitz LM, Fogarty KE, Corvera S.  J Cell Sci. 2008 Oct 15;121(Pt 20):3445-58. Epub 2008 Sep 30.PMID: 18827013 [PubMed - indexed for MEDLINE]

The FLYWCH transcription factors FLH-1, FLH-2, and FLH-3 repress embryonic expression of microRNA genes in C. elegans.

Ow MC, Martinez NJ, Olsen PH, Silverman HS, Barrasa MI, Conradt B, Walhout AJ, Ambros V.  Genes Dev. 2008 Sep 15;22(18):2520-34.PMID: 18794349 [PubMed - indexed for MEDLINE]

Enhanced angiogenesis in obesity and in response to PPARgamma activators through adipocyte VEGF and ANGPTL4 production.

Gealekman O, Burkart A, Chouinard M, Nicoloro SM, Straubhaar J, Corvera S.Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1056-64. Epub 2008 Aug 26.PMID: 18728224 [PubMed - indexed for MEDLINE]

A molecular circuit composed of CPEB-1 and c-Jun controls growth hormone-mediated synaptic plasticity in the mouse hippocampus.

Zearfoss NR, Alarcon JM, Trifilieff P, Kandel E, Richter JD.  J Neurosci. 2008 Aug 20;28(34):8502-9.PMID: 18716208 [PubMed - indexed for MEDLINE

mirWIP: microRNA target prediction based on microRNA-containing ribonucleoprotein-enriched transcripts.

Hammell M, Long D, Zhang L, Lee A, Carmack CS, Han M, Ding Y, Ambros V.  Nat Methods. 2008 Sep;5(9):813-819. Epub 2008 Aug 17.PMID: 18711361 [PubMed - as supplied by publisher]

Evidence for a pathogenic determinant in HIV-1 Nef involved in B cell dysfunction in HIV/AIDS.

Swingler S, Zhou J, Swingler C, Dauphin A, Greenough T, Jolicoeur P, Stevenson M.  Cell Host Microbe. 2008 Jul 17;4(1):63-76. PMID: 18621011 [PubMed - indexed for MEDLINE]

Crystal structure of the outer membrane protein OpdK from Pseudomonas aeruginosa.

Biswas S, Mohammad MM, Movileanu L, van den Berg B.Structure. 2008 Jul;16(7):1027-35.PMID: 18611376 [PubMed - indexed for MEDLINE]

PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans. 

Batista PJ, Ruby JG, Claycomb JM, Chiang R, Fahlgren N, Kasschau KD, Chaves DA, Gu W, Vasale JJ, Duan S, Conte D Jr, Luo S, Schroth GP, Carrington JC, Bartel DP, Mello CC
Mol Cell. 2008 Jul 11;31(1):67-78. Epub 2008 Jun 19.PMID: 18571452 [PubMed - indexed for MEDLINE]

A Rad51 presynaptic filament is sufficient to capture nucleosomal homology during recombinational repair of a DNA double-strand break.

Sinha M, Peterson CL.  Mol Cell. 2008 Jun 20;30(6):803-10.PMID: 18570881 [PubMed - indexed for MEDLINE]

Outer-membrane transport of aromatic hydrocarbons as a first step in biodegradation.

Hearn EM, Patel DR, van den Berg B.  Proc Natl Acad Sci U S A. 2008 Jun 24;105(25):8601-6. Epub 2008 Jun 16.PMID: 18559855 [PubMed - indexed for MEDLINE]

Preferential utilization of Imp7/8 in nuclear import of Smads.

Yao X, Chen X, Cottonham C, Xu LJ Biol Chem. 2008 Aug 15;283(33):22867-74. Epub 2008 Jun 2.PMID: 18519565 [PubMed - indexed for MEDLINE]

Cidea is associated with lipid droplets and insulin sensitivity in humans. 

Puri V, Ranjit S, Konda S, Nicoloro SM, Straubhaar J, Chawla A, Chouinard M, Lin C, Burkart A, Corvera S, Perugini RA, Czech MP.  Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7833-8. Epub 2008 May 28.PMID: 18509062 [PubMed - indexed for MEDLINE]

Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction.

Sharova N, Wu Y, Zhu X, Stranska R, Kaushik R, Sharkey M, Stevenson M.PLoS Pathog. 2008 May 2;4(5):e1000057.PMID: 18451984 [PubMed - indexed for MEDLINE]

A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes.

Hagan GN, Lin Y, Magnuson MA, Avruch J, Czech MP.  Mol Cell Biol. 2008 Jul;28(13):4215-26. Epub 2008 Apr 21.PMID: 18426911 [PubMed - indexed for MEDLINE]

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes.

Guilherme A, Virbasius JV, Puri V, Czech MP.  Nat Rev Mol Cell Biol. 2008 May;9(5):367-77. Review.PMID: 18401346 [PubMed - indexed for MEDLINE]

Chromatin immunoprecipitation (ChIP) coupled to detection by quantitative real-time PCR to study transcription factor binding to DNA in Caenorhabditis elegans.

Mukhopadhyay A, Deplancke B, Walhout AJ, Tissenbaum HA.  Nat Protoc. 2008;3(4):698-709.PMID: 18388953 [PubMed - indexed for MEDLINE]

Natural resistance of human immunodeficiency virus type 1 to the CD4bs antibody b12 conferred by a glycan and an arginine residue close to the CD4 binding loop.

Duenas-Decamp MJ, Peters P, Burton D, Clapham PR.  J Virol. 2008 Jun;82(12):5807-14. Epub 2008 Apr 2.PMID: 18385254 [PubMed - indexed for MEDLINE]

Characterization of multilayered nanoparticles encapsulated in yeast cell wall particles for DNA delivery.

Soto ER, Ostroff GR.  Bioconjug Chem. 2008 Apr;19(4):840-8. Epub 2008 Apr 1. PMID: 18376856 [PubMed - indexed for MEDLINE]

A systematic characterization of factors that regulate Drosophila segmentation via a bacterial one-hybrid system.

Noyes MB, Meng X, Wakabayashi A, Sinha S, Brodsky MH, Wolfe SA.
Nucleic Acids Res. 2008 May;36(8):2547-60. Epub 2008 Mar 10. PMID: 18332042 [PubMed - indexed for MEDLINE]

Genetics. Dwarfism, where pericentrin gains stature.

Delaval B, Doxsey S.  Science. 2008 Feb 8;319(5864):732-3. No abstract available. PMID: 18258883 [PubMed - indexed for MEDLINE]

Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors.

Peters PJ, Duenas-Decamp MJ, Sullivan WM, Brown R, Ankghuambom C, Luzuriaga K, Robinson J, Burton DR, Bell J, Simmonds P, Ball J, Clapham PR.  Retrovirology. 2008 Jan 18;5:5 PMID: 18205925 [PubMed - indexed for MEDLINE]

Identification and characterization of HIV-1 CD8+ T cell escape variants with impaired fitness.

Sanchez-Merino V, Farrow MA, Brewster F, Somasundaran M, Luzuriaga K.  J Infect Dis. 2008 Jan 15;197(2):300-8. PMID: 18177249 [PubMed - indexed for MEDLINE



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